Melanotan 1
- CAS No.
- 75921-69-6
- Chemical Name:
- Melanotan 1
- Synonyms
- NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
- CBNumber:
- CB4252333
- Molecular Formula:
- C78H111N21O19
- Molecular Weight:
- 1646.85
- MDL Number:
- MFCD00151715
- MOL File:
- 75921-69-6.mol
- MSDS File:
- SDS
Density | 1.46±0.1 g/cm3(Predicted) |
---|---|
RTECS | OS1830200 |
storage temp. | −20°C |
form | Solid |
pka | 4.43±0.10(Predicted) |
Water Solubility | Soluble to 0.60 mg/ml in sterile water |
Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
InChIKey | UAHFGYDRQSXQEB-LEBBXHLNSA-N |
CAS DataBase Reference | 75921-69-6(CAS DataBase Reference) |
FDA UNII | QW68W3J66U |
NCI Drug Dictionary | afamelanotide |
ATC code | D02BB02 |
Melanotan 1 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M8764 | [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC) | 75921-69-6 | 1mg | $145.8 | 2024-03-01 | Buy |
Alfa Aesar | J66191 | [Nle4, D-Phe7] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt | 75921-69-6 | 1mg | $161 | 2024-03-01 | Buy |
Tocris | 3013 | [Nle4,D-phe7]-alpha-MSH | 75921-69-6 | 1 | $184 | 2021-12-16 | Buy |
Usbiological | 256004 | [Nle4,D-Phe7]-α-MSH | 75921-69-6 | 1mg | $432 | 2021-12-16 | Buy |
Biosynth Carbosynth | FM39599 | Melanotan 1 | 75921-69-6 | 5mg | $456 | 2021-12-16 | Buy |
Melanotan 1 Chemical Properties,Uses,Production
Features
Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.
Uses
Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.
Definition
ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.
General Description
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.
Biochem/physiol Actions
[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.
Side effects
The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.
storage
Store at -20°C
Melanotan 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
zhuzhou dingcheng meihei comestic co.,ltd | +undefined18873369619 | dingchengbusiness8@163.com | China | 241 | 58 |
Hebei Xunou new energy Technology Co., LTD | +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 | sales2@qschem-pharma.com | China | 46 | 58 |
Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 294 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 874 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Related articles
- Melanotan 1: mechanisms of action, clinical applications and safety
- Melanotan 1, a synthetic analogue of α-MSH, promotes tanning and potentially treating skin conditions. Lack of regulatory appr....
- Dec 8,2023
- Introduction of Melanotan I
- Melanotan I(Afamelanotide) is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-s....
- Nov 24,2021
View Lastest Price from Melanotan 1 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-26 | Melanotan 1
75921-69-6
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | ||
2024-04-26 | (Nle4,D-Phe7)-α-MSH trifluoroacetate salt
75921-69-6
|
US $50.00-30.00 / g | 1g | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | ||
2024-04-26 | Melanotan 1
75921-69-6
|
US $30.00 / box | 1box | 98% | 2000box | hebei hongtan Biotechnology Co., Ltd |
- Melanotan 1
75921-69-6
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD
- (Nle4,D-Phe7)-α-MSH trifluoroacetate salt
75921-69-6
- US $50.00-30.00 / g
- 98%
- Hebei Kangcang new material Technology Co., LTD
- Melanotan 1
75921-69-6
- US $30.00 / box
- 98%
- hebei hongtan Biotechnology Co., Ltd
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