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Piperazine citrate

CAS No.
144-29-6
Chemical Name:
Piperazine citrate
Synonyms
ANTEPAR;Pinozan;PARAZINE;Patazine;Piperasol;Citraazine;Coliurinal;PIPERAZINE CITRATE;PiperazineCitrateBp;Tripiperazindicitrat
CBNumber:
CB4258805
Molecular Formula:
C24H46N6O14
Molecular Weight:
642.65
MDL Number:
MFCD00038961
MOL File:
144-29-6.mol
MSDS File:
SDS
Last updated:2024-07-25 20:04:51

Piperazine citrate Properties

Melting point 183-187℃
Boiling point 208℃[at 101 325 Pa]
Density 0.741[at 20℃]
vapor pressure 56.928Pa
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in DMSO
form powder to crystal
color White to Almost white
Water Solubility 54g/L at 24℃
Merck 14,7464
LogP -1.15
CAS DataBase Reference 144-29-6(CAS DataBase Reference)
FDA UNII RI85381D5G
EPA Substance Registry System Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
Signal word  Danger
Hazard statements  H317-H314-H319
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  1
RTECS  TL3485000
HS Code  29335990
NFPA 704
0
2 0

Piperazine citrate price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P2000000 Piperazine citrate European Pharmacopoeia (EP) Reference Standard 144-29-6 P2000000 $150 2024-03-01 Buy
TCI Chemical P0449 Piperazine Citrate Hydrate >98.0%(T) 144-29-6 25g $31 2024-03-01 Buy
TCI Chemical P0449 Piperazine Citrate Hydrate >98.0%(T) 144-29-6 500g $71 2024-03-01 Buy
TRC P479890 Piperazine citrate 144-29-6 25g $140 2021-12-16 Buy
TRC P479890 Piperazine citrate 144-29-6 100g $275 2021-12-16 Buy
Product number Packaging Price Buy
P2000000 P2000000 $150 Buy
P0449 25g $31 Buy
P0449 500g $71 Buy
P479890 25g $140 Buy
P479890 100g $275 Buy

Piperazine citrate Chemical Properties,Uses,Production

Description

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Chemical Properties

Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.

Uses

Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.

Indications

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

brand name

Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).

Flammability and Explosibility

Not classified

Mechanism of action

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Pharmacokinetics

Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.

Piperazine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 232)Suppliers
Supplier Tel Email Country ProdList Advantage
Masteam Bio-tech Co., Ltd.
+86-15200345168 +86-15200345168 bruce.lei@masteam.com CHINA 153 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12460 58
Hebei Guanlang Biotechnology Co,.LTD
+86-19930503253; +8619930503252 daisy@crovellbio.com China 5852 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618740459177 sarah@tnjone.com China 1142 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21673 55
Chembon Pharmaceutical Co., Ltd.
+86-28-8425-2981 CHINA 724 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9337 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29897 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872 christine@shengqipharm.com CHINA 491 58

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View Lastest Price from Piperazine citrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Piperazine Citrate pictures 2024-07-25 Piperazine Citrate
144-29-6
US $10.00 / kg 1kg 98% 10 ton Hebei Guanlang Biotechnology Co,.LTD
Piperazine citrate pictures 2024-07-25 Piperazine citrate
144-29-6
US $0.00-0.00 / Kg/Drum 1KG 98.5%min 10 TONS WUHAN FORTUNA CHEMICAL CO., LTD
Piperazine Citrate pictures 2024-04-16 Piperazine Citrate
144-29-6
US $0.00 / kg 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
CITRIC ACID SESQUIPIPERAZINE SALT PIPERAZINE CITRATE PIPERAZINE CITRATE SALT PARAZINE TRIPIPERAZINE DICITRATE PiperazineCitrateBp Tripiperazindicitrat PIPERAZINE CITARATE SALT PIPERAZINE CITRATE / TRIPIPERAZINE DICITRATE Citric acid hydrate sesquipiperazine salt 3Piperazine·2citric acid PiperazineCitrate,Piperazine Citrate Piperazine Citrate (200 mg) Citraazine Coliurinal Patazine Pinozan Piperasol piperazine 2-hydroxypropane-1,2,3-tricarboxylate Piperazidine citrate PIPERAZINE CITRATE ISO 9001:2015 REACH Pharmaceutical Intermediate Citrate Hydrate CAS?144-29-6 Piperazine citrate (P2000000) Piperazine Citrate (1541805) PIPERAZIN CITRATE HYDRATE Piperazine citrate CRS PiperazineCitrateHydrate> ANTEPAR Piperazine citrate,inhibit,Piperazine,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,Inhibitor,1,4-Diazacyclohexane,GABA Receptor Piperazine Citrate Hydrate, ≥ 98.0% 144-29-6 C12H30N62C6H8O7xH2O C12H30N6C12H16O14xH2O C4H10N232C6H8O7 C24H46N6O14 C12H30N62C6H8O7 C6H8O732C4H10N2 2C6H8O73C4H10N2 Piperazines Heterocyclic Building Blocks Building Blocks API Piperidines, Piperidones, Piperazines