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Magnesium stearate

Surfactant Content Analysis Toxicity Limited use Chemical Properties Uses Production method
Magnesium stearate
Magnesium stearate structure
CAS No.
557-04-0
Chemical Name:
Magnesium stearate
Synonyms
Dolomol;petracmg20nf;MAGENSIUM STEARATE;MAGNESIUM STEARATE;MEGNESIUM STEATATE;Magnesiumdistearat;stearatedemagnesium;magnesiumdistearate;MagnesiuM stearates;Magnesium Stearate Bp
CBNumber:
CB5330900
Molecular Formula:
C36H70MgO4
Formula Weight:
591.24
MOL File:
557-04-0.mol

Magnesium stearate Properties

Melting point:
200 °C(lit.)
Density 
1.028g/cm3
storage temp. 
Store at RT.
solubility 
alcohol: insoluble
form 
Fine Powder
color 
White
PH
7 (H2O) (slurry)
Water Solubility 
Insoluble
Merck 
14,5690
BRN 
3919702
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
DRJIJXNWSSRTTE-UHFFFAOYSA-M
CAS DataBase Reference
557-04-0(CAS DataBase Reference)
EPA Substance Registry System
Octadecanoic acid, magnesium salt(557-04-0)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  -
RTECS  WI4390000
TSCA  Yes
HS Code  29157030
Hazardous Substances Data 557-04-0(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

Magnesium stearate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 26454 Magnesium stearate puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.) 557-04-0 1kg $40.7 2018-11-13 Buy
Sigma-Aldrich 1374340 Magnesium stearate United States Pharmacopeia (USP) Reference Standard 557-04-0 5g $352.8 2018-11-13 Buy
TCI Chemical S0238 Magnesium(II) Stearate 557-04-0 25g $13 2018-11-22 Buy
TCI Chemical S0238 Magnesium(II) Stearate 557-04-0 250g $30 2018-11-22 Buy
Alfa Aesar A16244 Magnesium stearate 557-04-0 250g $39.9 2018-11-13 Buy

Magnesium stearate Chemical Properties,Uses,Production

Surfactant

Magnesium stearate is a kind of fatty acid salt type anionic surfactant with its appearance being white powder with slight special smell and creamy feeling. It can be soluble in hot aliphatic hydrocarbons, hot arene and hot grease but insoluble in alcohol and water with being decomposed into stearic acid and corresponding magnesium salts in case of acid. Magnesium stearate has an excellent adhesion property to the skin with excellent lubrication property. It can be applied to powder products in cosmetics and can improve adhesion and lubrication.
Magnesium stearate can be used as PVC heating stabilizers with the stability performance being similar to calcium stearate and can be combined with zinc or calcium soaps for being applied to food packaging material but without very wide application.
Magnesium stearate can be used as a mold releasing agent of plastic products, face powder of cosmetics, the raw material of skin ointment, the powder molding tablet of pharmaceutical tablets and translucent flatting agent of paint.
Laboratory, through the replacement reaction of sodium stearate and magnesium sulfate, is able to get finished product of magnesium stearate and can also apply the combination reaction between edible solid organic acids (stearic acid, palmitic acid) mixture and magnesium oxide compounds and further refinement to make it.

Content Analysis

Accurately weigh sample of about l g, add 50 mL of 0.1mol/L hydrochloric acid. Apply boiling for about 30min, or until the precipitated fatty layer reaches clarification; add water to the original volume if necessary. Cool, filter, rinse the filter and filter reside with water to until that the treated solution is not acidic to litmus. The filtrate is neutralized with 1mol/L sodium hydroxide solution to being neutralization of the litmus. Upon thorough stirring with a magnetic stirrer, use 0.05mol/L of EDTA for titration as follow: to a 50 mL burette, add 30 mL titration solution. Then further add 5 mL of ammonia/potassium chloride buffer solution (TS-12) and 0.15 mL of eriochrome black test solution (TS-97), and then continue the titration to the blue endpoint. Every milliliter of 0.05 mol/L solution of EDTA disodium is equivalent to 0.15 mg of MgO2.
This information is edited by Xiongfeng Dai from Chemicalbook.

Toxicity

ADI unrestricted provisions (FAO/WHO, 2001).
GRA: (FDA, §184.1440, 2000).

Limited use

FAO/WHO (g/kg): apply glucose powder and sucrose powder 15 (in the absence of starch); soup 15.
GB 2760-2001: gum base agent, candy, GMP as the limit; preserves 0.8g/kg.

Chemical Properties

It appears as bright white soft powder with the industrial products containing a small amount of oleic acid and 7% magnesium oxide and is odorless and tasteless. It is slightly soluble in water and soluble in hot ethanol.

Uses

This product can be used as the thermal stabilizer for PVC, the raw material of cosmetics, flour, soothing ointment and medicine tablet (forming agents, emollients); it can be applied to the bakelite powder to make it be lubricant, bright and transparent; it can also be applied to paint industry for being used as transparent flatting agents. The metal soaps for being used as a PVC stabilizer are mostly the high-grade fatty acid salt of cadmium, barium, calcium, zinc and magnesium. Forming groups belong to the salts of stearic acid and lauric acid. The performance of the metal soaps stabilizers is different with different types of metals and acid groups with the generally principles being as follow: Heat resistance: cadmium, zinc soap has an excellent heating resistance during the initial period; barium, calcium, magnesium and strontium soap have a long-term heat resistance with lead soap existing in the middle. Weather resistance: cadmium, zinc, lead, barium and tin soap are better. Workability: lead and cadmium soap have excellent lubricating property but acid radicals is also very influential to the lubrication. For the same kind of metal, it is better as aliphatic than the aromatic group. For aliphatic acid radical, longer molecular chain will also have a better lubrication property. It is widely used in food, pharmaceuticals, paints, plastics, rubber, textiles, etc. Barium, calcium, magnesium, strontium soap has a poor lubrication property but with excellent gelling property. Plate-out property: barium, calcium, magnesium, and strontium soaps are also prone to have plate-out phenomenon while zinc, cadmium and lead soap are less prone to get plate-out issue with longer molecular chain fatty acid soaps having more severe plate-out problem as well as more severe blooming issue. Lead and cadmium soap have high toxicity together with sulfide pollution. In the non-toxic formulation, people mostly apply calcium and zinc soap; sulfide contamination resistant formula more barium and zinc soaps. Magnesium stearate can be regarded as being non-toxic, the United States, Germany and Japan allow it to be applied to products being contact with food. However, it doesn’t have wide application to be applied as PVC heat stabilizers. In China and some other countries Pharmacopoeia, there are always records of this specie. The pharmacopeia has also made provisions on the magnesium content, moisture, heavy metals, iron, sulfate and chloride content.

Production method

Magnesium stearate can be produced through the following procedure: first get the sodium stearate through the saponification between stearic acid and sodium; then the sodium stearate has double decomposition reaction with magnesium sulfate to get the finished product. Stearic acid and water was added to the reaction pot and heated to 85 ℃, stirring to dissolve, slowly add them to the sodium hydroxide solution preheated to 75 ℃. After the saponification reaction was completed, the temperature was controlled at 72 ℃ and slowly added to the magnesium sulfate solution preheated to 55 ℃ upon stirring. After metathesis, apply centrifuge to remove the water. The filtering cake was washed with water until sulfate ion requirement is met, then dry, apply air drying, sifting to obtain the finished products with the yield of stearic acid being 100%.
It is produced through the combination reaction between magnesium oxide and food grade solid mixed fatty acids (mainly stearic acid) and further refinement.

Description

Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

Chemical Properties

soft, light white powder(s); odorless, tasteless; nonflammable used in baby dusting powder(s) and as tablet lubricant [HAW93] [MER06]

Chemical Properties

Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin.

Chemical Properties

Magnesium stearate is a compound of magnesium with a mixture of solid organic acids obtained from edible sources and consists chiefly of variable proportions of magnesium stearate and magnesium palmitate. It occurs as a fine, white, bulky powder having a faint, characteristic odor. It is unctuous and is free from grittiness. It is insoluble in water, in alcohol, and in ether. It conforms to the regulations of the U.S. Food and Drug Administration pertaining to specifications for salts of fatty acids derived from edible fat sources.

Uses

Magnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.

Uses

widely used in the fields of the plastic, mold-releasing agent for tablets (need meeting the medicine criterion), emulsifying agents of cosmetics. It also can conjugate with Ca Soap as stabilizer of PVC.

Uses

In baby dusting powders; as tablet lubricant.

Uses

Magnesium stearate is often used as a anti-adherent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, etc., but not that it reduces the overall bioavailability of those ingredients. As a food additive or pharmaceutical excipient, its E number is E470b.
Magnesium stearate is also used to bind sugar in hard candies like mints, and is a common ingredient in baby formulas. In pure powder form, the substance can be a dust explosion hazard, although this issue is effectively insignificant beyond the manufacturing plants using it.
Magnesium stearate is manufactured from both animal and vegetable oils. Some nutritional supplements specify that the magnesium stearate used is sourced from vegetables.
Magnesium stearate is a major component of "bathtub rings." When produced by soap and hard water, magnesium stearate and calcium stearate both form a white solid insoluble in water, and are collectively known as "soap scum.".

Preparation

Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.

Production Methods

Magnesium stearate is prepared either by the interaction of aqueous solutions of magnesium chloride with sodium stearate or by the interaction of magnesium oxide, hydroxide, or carbonate with stearic acid at elevated temperatures.

Definition

Mg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.

Pharmaceutical Applications

Magnesium stearate is widely used in cosmetics, foods, and pharmaceutical formulations. It is primarily used as a lubricant in capsule and tablet manufacture at concentrations between 0.25% and 5.0% w/w. It is also used in barrier creams.

Safety Profile

Slightly toxic by ingestion. Spontaneously combustible. When heated to decomposition it emits acrid smoke and toxic fumes.

Safety

Magnesium stearate is widely used as a pharmaceutical excipient and is generally regarded as being nontoxic following oral administration. However, oral consumption of large quantities may produce a laxative effect or mucosal irritation.
No toxicity information is available relating to normal routes of occupational exposure. Limits for heavy metals in magnesium stearate have been evaluated in terms of magnesium stearate worstcase daily intake and heavy metal composition.
Toxicity assessments of magnesium stearate in rats have indicated that it is not irritating to the skin, and is nontoxic when administered orally or inhaled.
Magnesium stearate has not been shown to be carcinogenic when implanted into the bladder of mice.
LD50 (rat, inhalation): >2 mg/L
LD50 (rat, oral): >10 g/kg

storage

Magnesium stearate is stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Incompatible with strong acids, alkalis, and iron salts. Avoid mixing with strong oxidizing materials. Magnesium stearate cannot be used in products containing aspirin, some vitamins, and most alkaloidal salts.

Regulatory Status

GRAS listed. Accepted as a food additive in the USA and UK. Included in the FDA Inactive Ingredients Database (oral capsules, powders, and tablets; buccal and vaginal tablets; topical preparapreparations; intravitreal implants and injections). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Listed on the US TSCA inventory.

Magnesium stearate Preparation Products And Raw materials

Raw materials

Preparation Products


Magnesium stearate Suppliers

Global( 304)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23983 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1750 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

View Lastest Price from Magnesium stearate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-03 Salicylic acid in stock Factory
69-72-7
US $1.10 / kg 1 KG/CTN High quality Factory bulk manufacturer Chemwill Asia Co.,Ltd.
2018-12-14 Magnesium stearate
557-04-0
US $1.00 / kg 1kg 98% CARA24 career henan chemical co

Magnesium stearate Spectrum


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