2-(Bromomethyl)-5-(trifluoromethyl)furan
- CAS No.
- 17515-77-4
- Chemical Name:
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
- Synonyms
- 2-(BROMOMETHYL)-5-(TRIFLUOROMETHYL)FURAN;2-(Bromomethyl)-5-(trifluoromethyl)furane;Furan,2-(broMoMethyl)-5-(trifluoroMethyl)-;2-(Bromomethyl)-5-(trifluoromethyl)furan97%;2-(Bromomethyl)-5-(trifluoromethyl)furan 97%
- CBNumber:
- CB5355572
- Molecular Formula:
- C6H4BrF3O
- Molecular Weight:
- 228.99
- MDL Number:
- MFCD03086219
- MOL File:
- 17515-77-4.mol
- MSDS File:
- SDS
| Boiling point | 38 °C |
|---|---|
| Density | 1.693±0.06 g/cm3(Predicted) |
| refractive index | 1.45 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| color | Clear Colourless |
| InChI | InChI=1S/C6H4BrF3O/c7-3-4-1-2-5(11-4)6(8,9)10/h1-2H,3H2 |
| InChIKey | YNHVBNGRNNVEMD-UHFFFAOYSA-N |
| SMILES | O1C(C(F)(F)F)=CC=C1CBr |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314 | |||||||||
| Precautionary statements | P260-P280-P312 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-36/37/38-43 | |||||||||
| Safety Statements | 26-36/37/39-45-36/37 | |||||||||
| RIDADR | 1760 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2932190090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Skin Sens. 1 |
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| NFPA 704 |
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2-(Bromomethyl)-5-(trifluoromethyl)furan price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5800 | 2-(Bromomethyl)-5-(trifluoromethyl)furan >97.0%(GC) | 17515-77-4 | 200mg | $37 | 2026-04-30 | Buy |
| TCI Chemical | B5800 | 2-(Bromomethyl)-5-(trifluoromethyl)furan >97.0%(GC) | 17515-77-4 | 1g | $111 | 2026-04-30 | Buy |
| Usbiological | 414086 | 2-(Bromomethyl)-5-(trifluoromethyl)furan | 17515-77-4 | 250mg | $355 | 2026-06-03 | Buy |
| Usbiological | 414086 | 2-(Bromomethyl)-5-(trifluoromethyl)furan | 17515-77-4 | 1g | $468 | 2026-06-03 | Buy |
| TRC | TRC-B687925-250MG | 2-(Bromomethyl)-5-(trifluoromethyl)furan | 17515-77-4 | 250mg | $109 | 2026-06-03 | Buy |
2-(Bromomethyl)-5-(trifluoromethyl)furan Chemical Properties, Uses, Production
Uses
2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.
Synthesis
17515-75-2
17515-77-4
The general procedure for the synthesis of 2-bromomethyl-5-trifluoromethylfuran from 5-methyl-2-trifluoromethylfuran was as follows: to a solution of 2-methyl-5-(trifluoromethyl)furan (4 g, 26.6 mmol) in chloroform (60 mL) was added sequentially N-bromosuccinimide (5.2 g, 29.3 mmol) and 2,2'-azobis(isobutyronitrile) (220 mg 1.33 mmol). The reaction mixture was heated to reflux for 15 minutes. After completion of the reaction, the reaction solution was cooled, poured into water (200 mL) and extracted with chloroform. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to give 2-(bromomethyl)-5-(trifluoromethyl)furan (4.79 g, 78% yield). Infrared spectrum of the product (KBr pressed sheet) νmax/cm-1 : 1738, 1688, 1599, 1559. 1H-NMR (CDCl3) δ: 4.46 (2H, s), 6.45 (1H, d, J = 3.8 Hz), 6.75 (1H, d, J = 3.8 Hz).
References
[1] Patent: EP1362846, 2003, A1. Location in patent: Page/Page column 125
2-(Bromomethyl)-5-(trifluoromethyl)furan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Shining Pharm Co.,Ltd | 18866891188 18866891188 | zhaojiangxia@shiningpharm.com | China | 203 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Suzhou Zehou Biotechnology Co. , Ltd. | 0512-68716880 19984816880 | sales@growingchem.com | China | 230 | 64 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2828 | 64 |
View Latest Price from 2-(Bromomethyl)-5-(trifluoromethyl)furan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co | |
 |
2019-07-06 | 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
|
$7.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
- $7.00
- 99%
- Career Henan Chemical Co
-
- 2-(Bromomethyl)-5-(trifluoromethyl)furan
17515-77-4
- $7.00
- 99%
- Career Henan Chemical Co
