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Recrystallization Temperature of initiator Chemical properties Uses Production method category Toxicity grading Acute toxicity Explosive hazardous characteristics Flammability hazard characteristics Storage characteristics Extinguishing agent
2,2'-Azobis(2-methylpropionitrile) structure
Chemical Name:
AIBN;AIVN;AZDH;V-60;Vazo;vazo64;chkhz57;Vazo 64;AIBN-64;ChKhZ 57
Molecular Formula:
Formula Weight:
MOL File:

2,2'-Azobis(2-methylpropionitrile) Properties

Melting point:
102-104 °C (dec.)(lit.)
Boiling point:
281.68°C (rough estimate)
refractive index 
Flash point:
storage temp. 
Water Solubility 
Stability Flammable solid. Shock sensitive. Thermally unstable. May be explosive in combination with acetone or heptane. Incompatible with oxidizing agents.
CAS DataBase Reference
78-67-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Propanenitrile, 2,2'-azobis[2-methyl- (78-67-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H225-H304-H315-H336-H361d-H373-H319-H242-H302+H332-H412
Precautionary statements  P210-P261-P281-P301+P310-P331-P280-P304+P340+P312-P305+P351+P338-P337+P313-P403+P235-P220-P234-P370+P378
Hazard Codes  E,Xn,F,Xi
Risk Statements  2-11-20/22-52/53-67-65-48/20-38-63-66-36
Safety Statements  39-41-47-61-62-36/37-16-26
RIDADR  UN 3234 4.1
WGK Germany  2
RTECS  UG0800000
HazardClass  4.1
PackingGroup  II
HS Code  29269090

NFPA 704

Diamond Hazard Value Description
3 3
Health   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   3 Capable of detonation or explosive decomposition but requires a strong initiating source, must be heated under confinement before initiation, reacts explosively with water, or will detonate if severely shocked (e.g. ammonium nitrate, cesium, hydrogen peroxide)

(NFPA, 2010)

2,2'-Azobis(2-methylpropionitrile) price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 441090 2,2′-Azobis(2-methylpropionitrile) 98% 78-67-1 25g $41.7 2018-11-20 Buy
Sigma-Aldrich 441090 2,2′-Azobis(2-methylpropionitrile) 98% 78-67-1 100g $128 2018-11-20 Buy
Sigma-Aldrich 768375 Azobisisobutyronitrile 12wt. % in acetone 78-67-1 500ml $246 2018-11-20 Buy
Sigma-Aldrich 714887 2,2′-Azobis(2-methylpropionitrile) solution 0.2M in toluene 78-67-1 100ml $53.5 2018-11-20 Buy
Sigma-Aldrich 768375 Azobisisobutyronitrile 12wt. % in acetone 78-67-1 100ml $71.1 2018-11-20 Buy

2,2'-Azobis(2-methylpropionitrile) Chemical Properties,Uses,Production


1, recrystallize twice a chemically pure 2,2'-Azobis(2-methylpropionitrile) with methanol (by 1:12) and air-dry in a ventilated dark overnight, then place in a vacuum oven with phosphorus pentoxide as a desiccant, vacuum degree 1.013 * 105Pa, under reduced pressure, and dry to 24h.Refined 2,2'-Azobis(2-methylpropionitrile) needs to be put in the colored jar, sealed and kept in cold dark place.
2, add 50ml 95% alcohol into 150ml Erlenmeyer flask equipped with a reflux condenser , heat in a water bath to near boiling, quickly add 5gAIBN, shak to make it be completely dissolved (boiling time not too long, if too long, severe decomposition ), filter hot solution rapidly ( the funnel and filter flask using for filter must be warmed) and cool the filtrate to give white crystals, dry in a vacuum desiccator, a melting point of 102℃, store the product in a brown bottle, cryopreservation.

Temperature of initiator

2,2'-Azobis(2-methylpropionitrile) is a particularly excellent free radical initiator , nitrogen will be released by the decomposition when it is heated to about 70 ° C and free radicals (CH3) 2CCN is generated which is affected by cyano radical , more stable. It can react with other organic substrates, and then generates a new radical in annihilation of itself , causing chain reaction of free radicals (see radical reaction). At the same time, it can also be two coupled molecules, generating highly toxic tetramethoxysilane succinonitrile (TMSN).
AIBN melts when heated to 100~107 ° C and dramaticly decomposes, releases nitrogen and several organic nitrile compound toxic to humans, and may cause an explosion, fire. Slowly decomposes at room temperature, and it should be stored at 10 ° C or less. Away from fire, heat source. poisonous. Metabolizes into hydrocyanic acid in the blood, liver, brain and other tissues of animals.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical properties

White columnar crystals or white crystalline powder. Insoluble in water, soluble in methanol, ethanol, acetone, ether, petroleum ether and aniline and other organic solvents.


The polymerization initiator for Vinyl chloride, vinyl acetate, acrylonitrile and blowing agent for rubber, plastic , in an amount of 10% to 20%.
This product can also be used as curing agents, pesticides and organic synthesis intermediates.
This product is a highly toxic substance, mice are orally LD5017.2~25mg/kg, the organic cyanide released by the decomposition when it is heated has a greater poison on the human body .

Production method

Acetone, hydrazine hydrate and sodium cyanide as raw materials:
The temperature of condensation reaction above is 55~60 ℃, reaction time is 5h, and then cool down to 25~30 ℃ ,time is 2h. When to be cooled to below 10 ℃,begin to flow chlorine and carry out the reaction at below 20 ℃.
Ratio of material: HCN: acetone: hydrazine = 1L:1.5036kg:0.415kg.
Acetone cyanide alcohol and hydrazine hydrate react, and then the use of chlorine oxidation or amino nitrile with sodium hypochlorite oxidation.


Flammable solids

Toxicity grading

Middle toxic

Acute toxicity

Oral-rat LDL0: 670 mg/kg; Oral-Mouse LD50: 700 mg/kg

Explosive hazardous characteristics

Explosive when mixed with oxidants ; easily oxidized, unstable and intense heat decomposition, explosive when heated with heptane, acetone

Flammability hazard characteristics

Flammable in case of fire, high temperature, oxidant ; decomposition and generating combustible gas in case of thermal ; combustion produces toxic fumes of nitrogen oxides

Storage characteristics

Treasury ventilation low-temperature drying; and separated from oxidants

Extinguishing agent

Water, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent

Chemical Properties

white solid

Chemical Properties

Azobisisobutylonitrile is a white crystalline compound.


Used as an initiator in the synthesis of highly cross-linked Poly(divinylbenzene) (PDVB) polymers. 1 Used as an initiator in the polymerization process of 2-hydroxyethyl methacrylate (HEMA). 2

General Description

Insoluble in water and denser than water. Moderately toxic by ingestion. Readily ignited by sparks or flames. Burns intensely and persistently. Toxic oxides of nitrogen produced during combustion. Used as a catalyst, in vinyl polymerizations and a blowing agent for plastics.

Air & Water Reactions

Dust may form an explosive mixture in air. Insoluble in water.

Reactivity Profile

Self-decomposition or self-ignition may be triggered by heat, chemical reaction, friction or impact. Self-accelerating decomposition may occur if the specific control temperature is not maintained. These materials are particularly sensitive to temperature rises. 2,2'-Azobis(2-methylpropionitrile) is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.


Toxic by ingestion.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Easily oxidized, unstable. Violent exothermic decomposition when heated. Solution in acetone may decompose explosively. Explodes when heated with heptane. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES. A free-radcal generator.

Potential Exposure

Azobisisobutylonitrile is both a nitrile and azo compound. Used as a polymerization initiator, free radical generator (or initiator); as a catalyst in vinyl polymerizations; as a blowing agent for elastomers and plastics.


UN3234 Self-reactive solid type C, temperature controlled materials, Hazard Class: 4.1; Labels: 4.1- Flammable solid, Technical Name Required.


Flammable; dust may form explosive mixture with air. Unstable and easily oxidized material; keep away from oxidizers, strong acids. Keep at temperature not ≧30° C (this may vary by manufacturer). Risk of explosion from heat, shock, friction. Warming causes production of tetramethylsuccinonitrile and cyanide fumes. Keep away from acetone and other ketones, alcohols, lithium, aluminum, aldehydes, and hydrocarbons, such as heptane. Azo compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. This chemical is sensitive to prolonged exposure to heat. This chemical is incompatible with strong oxidizing agents.

2,2'-Azobis(2-methylpropionitrile) Preparation Products And Raw materials

Raw materials

Preparation Products

4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE Dichloroacetyl chloride super absorbent resin synthesized by microwave cation ion radiation 4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 2,1,3-Benzothiadiazol-5-ylmethanol 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID Dideoxyinosine 2,1,3-Benzothiadiazole-5-carbaldehyde 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID graft copolymer PAA-G-PIPA microsphere 2-(Bromomethyl)benzoic acid 2,6-Dichlorobenzaldehyde 5-Dibenzosuberenone 2-(DIPHENYLPHOSPHINO)ETHYLTRIETHOXYSILANE FTHALIDE 4-Benzofurazancarboxaldehyde 2-TRIFLUOROMETHYLQUINOLINE-7-CARBOXYLIC ACID 4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE a new kind of liquid crystal copolymer 3,7-dichloro-8-dichloro methyl quinoline METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE 3-QUINOLIN-2-YLPROPANOIC ACID 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE 2-Chlorobenzyl chloride Maleic acid-allyl alcohol copolymer dimethylacrolyl phenoxy propanestyrene copolymer optical plastics METHYL ALPHA-BROMO-2-CHLOROPHENYLACETATE 5-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE amphoteric super absorbent resin synthesized by microwave radiation Dicofol 3-PHENOXYPHENYLACETONITRILE 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 11-Bromoundecanoic acid Deflazacort 3-(PIPERIDINOMETHYL)BENZALDEHYDE 2-Nitroacetophenone 2,4-Dichlorobenzyl chloride 2-Nitrobenzyl bromide 4-(PYRROLIDIN-1-YLMETHYL)BENZENEBORONIC ACID, PINACOL ESTER 97%1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL]PYRROLIDINE

2,2'-Azobis(2-methylpropionitrile) Suppliers

Global( 271)Suppliers
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Mainchem Co., Ltd.
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View Lastest Price from 2,2'-Azobis(2-methylpropionitrile) manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-14 2,2'-Azobis(2-methylpropionitrile)
US $60.00 / KG 1KG 99.8% 10tons Hebei shuoxi biotechnology co. LTD
2019-07-03 2,2'-Azobis; 2-methylpropionitrile
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-08-06 2,2'-Azobis(2-methylpropionitrile)
US $1.00 / KG 1KG 99% Customized career henan chemical co

2,2'-Azobis(2-methylpropionitrile) Spectrum

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