Methylaminoformyl chloride
- CAS No.
- 6452-47-7
- Chemical Name:
- Methylaminoformyl chloride
- Synonyms
- Methylcarbamic chloride;n-methylaminoformyl chloride;METHYLCARBAMOYLCHLORIDE;N-Methylchloroformamide;Carbamic chloride, methyl-;METHYLAMINOFORMYL CHLORIDE;N-Methylcarbamoyl chloride;N-(Chloroformyl)methylamine;Methylcarbamic acid chloride;Carbamic chloride, N-methyl-
- CBNumber:
- CB5512113
- Molecular Formula:
- C2H4ClNO
- Molecular Weight:
- 93.51
- MDL Number:
- MFCD08703300
- MOL File:
- 6452-47-7.mol
- MSDS File:
- SDS
| Melting point | 45°C |
|---|---|
| Boiling point | 93°C (dec.) |
| Density | 1.185±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Acetonitrile, Chloroform (Slightly), DMSO |
| form | Solid |
| pka | 10.67±0.46(Predicted) |
| color | White to Off-White |
| Stability | Air Sensitive, Hygroscopic, Moisture Sensitive, Volatile |
| CAS DataBase Reference | 6452-47-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
Methylaminoformyl chloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS009330 | methylaminoformyl chloride AldrichCPR | 6452-47-7 | 100MG | $106 | 2023-06-20 | Buy |
| TRC | M295225 | MethylcarbamoylChloride | 6452-47-7 | 25g | $155 | 2021-12-16 | Buy |
| AK Scientific | C419 | N-Methylaminoformylchloride | 6452-47-7 | 5g | $49 | 2021-12-16 | Buy |
| Oakwood | 358405 | N-Methylcarbamoylchloride tech | 6452-47-7 | 5g | $49 | 2021-12-16 | Buy |
| AK Scientific | C419 | N-Methylaminoformylchloride | 6452-47-7 | 25g | $70 | 2021-12-16 | Buy |
Methylaminoformyl chloride Chemical Properties,Uses,Production
Description
Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
Uses
Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
Preparation
Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].
Uses
Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009
Methylaminoformyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
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- Dec 12，2019
View Lastest Price from Methylaminoformyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-19 | Methylaminoformyl chloride
6452-47-7
|
US $10.50 / kg | 1kg | 90% | 500TM/month | Hebei Duling International Trade Co. LTD | |
 |
2020-01-10 | Methylaminoformyl Chloride
6452-47-7
|
US $1.00 / g | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- Methylaminoformyl chloride
6452-47-7
- US $10.50 / kg
- 90%
- Hebei Duling International Trade Co. LTD
-
- Methylaminoformyl Chloride
6452-47-7
- US $1.00 / g
- 99%
- Career Henan Chemical Co