MIF Antagonist, ISO-1
- CAS No.
- 478336-92-4
- Chemical Name:
- MIF Antagonist, ISO-1
- Synonyms
- ISO-1;CS-1195;ISO-1 (ISO 1;MIF Antagonist;ISO-1, MIF Antagonist;MIF Antagonist, ISO-1;ISO 1;ISO1;MIF ANTAGONIST;ISO-1,Inhibitor,ISO1,inhibit;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester
- CBNumber:
- CB62521242
- Molecular Formula:
- C12H13NO4
- Molecular Weight:
- 235.24
- MDL Number:
- MFCD22376813
- MOL File:
- 478336-92-4.mol
- MSDS File:
- SDS
| Melting point | 114 °C |
|---|---|
| Boiling point | 365.0±48.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO. |
| pka | 9.22±0.30(Predicted) |
| form | Light yellow crystalline solid. |
| color | Off-white |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| FDA UNII | 7QFF3Z0V9X |
MIF Antagonist, ISO-1 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.05225 | InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem | 478336-92-4 | 10MG | $214 | 2024-03-01 | Buy |
| Sigma-Aldrich | 475837 | MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF. | 478336-92-4 | 5MG | $144 | 2024-03-01 | Buy |
| TCI Chemical | I1119 | ISO-1 | 478336-92-4 | 5MG | $85 | 2024-03-01 | Buy |
| TCI Chemical | I1119 | ISO-1 | 478336-92-4 | 25MG | $254 | 2024-03-01 | Buy |
| Alfa Aesar | J64947 | MIF Antagonist, ISO-1 | 478336-92-4 | 5mg | $114 | 2023-06-20 | Buy |
MIF Antagonist, ISO-1 Chemical Properties,Uses,Production
Description
ISO-1 (478336-92-4) is an antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis.1 Inhibits airway remodeling in mouse asthma model.2 ISO-1 also blocks MIF-induced autophagy.3?Active in cellular and mouse models.
Uses
MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 μM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
storage
Store at +4°C
References
1) Al-Abed et al. (2005), ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis; J. Biol. Chem., 280 2) Chen et al. (2010), ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma; Mol. Med., 16 400 3) Chuang et al. (2012), Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation; PLoS One, 7 e37613
MIF Antagonist, ISO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MIF Antagonist, ISO-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6710 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18455 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Nanjing Peiwill Biotechnology Co.,Ltd. | 025-57027729 15850702895 | 15850702895@163.com | China | 73 | 55 |
View Lastest Price from MIF Antagonist, ISO-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-23 | MIF Antagonist, ISO-1
478336-92-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
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- MIF Antagonist, ISO-1
478336-92-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.