ChemicalBook >> CAS DataBase List >>Motesanib
Motesanib
- CAS No.
- 453562-69-1
- Chemical Name:
- Motesanib
- Synonyms
- D06678;CS-1108;motesanib;Motesanib Base;AMG 706; AMG-706;AMG-706(Motesanib);Motesanib (AMG-706) Base);2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706
- CBNumber:
- CB01518524
- Molecular Formula:
- C22H23N5O
- Molecular Weight:
- 373.45
- MDL Number:
- MFCD10567689
- MOL File:
- 453562-69-1.mol
- MSDS File:
- SDS
Last updated:2023-09-04 16:42:00
| Melting point | 147-150°C |
|---|---|
| Boiling point | 517.3±50.0 °C(Predicted) |
| Density | 1.251 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White powder solid. |
| pka | 11.75±0.40(Predicted) |
| color | Pale Yellow |
| FDA UNII | U1JK633AYI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P362+P364-P302+P352-P305+P351+P338 |
| HS Code | 2933399990 |
Motesanib price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M732500 | Motesanib | 453562-69-1 | 50mg | $165 | 2021-12-16 | Buy |
| Usbiological | 017881 | Motesanib | 453562-69-1 | 5mg | $496 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1055-M100 | Motesanib ≥95% | 453562-69-1 | 100mg | $1069 | 2021-12-16 | Buy |
| AK Scientific | X4931 | Motesanib | 453562-69-1 | 500mg | $1265 | 2021-12-16 | Buy |
| Matrix Scientific | 132644 | N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide 97% | 453562-69-1 | 250mg | $630 | 2021-12-16 | Buy |
Motesanib Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
Uses
Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Definition
ChEBI: Motesanib is a pyridinecarboxamide.
target
VEGFR1
Motesanib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 141)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Xi'an Yutbon Pharmaceutical Technology Co., Ltd | 029-81140587 +8618717328141 | sales@yutbon.com | China | 437 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
View Lastest Price from Motesanib manufacturers
N-(3,3-diMethylindolin-6-yl){2-[(4-pyridylMethyl)-aMino](3-pyridyl)}-carboxaMide
3-PyridinecarboxaMide, N-(2,3-dihydro-3,3-diMethyl-1H-indol-6-yl)-2-[(4-pyridinylMethyl)aMino]-
Motesanib Base
AMG-706(Motesanib)
Motesanib (AMG-706) Base)
motesanib
N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide
N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706
D06678
CS-1108
AMG 706; AMG-706
2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-
453562-69-1
API
Inhibitors
Antineoplastic