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ANANDAMIDE

ANANDAMIDE
ANANDAMIDE structure
CAS No.
94421-68-8
Chemical Name:
ANANDAMIDE
Synonyms
AEA;ANANDAMIDE;anandamide(20.4,n-6);ARACHIDONYLETHANOLAMIDE;ARACHIDONOYL ETHANOLAMIDE;N-ARACHIDONOYLETHANOLAMINE;Anandamide(inTocrisolveTM100);Anandamide (in Tocrisolve 100);n-(2-hydroxyethyl)anachidonamide;n-arachidonoyl-2-hydroxyethylamide
CBNumber:
CB7168648
Molecular Formula:
C22H37NO2
Formula Weight:
347.53
MOL File:
94421-68-8.mol

ANANDAMIDE Properties

Density 
0.92 g/mL at 25 °C(lit.)
Flash point:
14 °C
storage temp. 
−20°C
solubility 
ethanol: soluble
form 
oil
color 
light yellow

SAFETY

Hazard Codes  F
Risk Statements  11
Safety Statements  24/25-16-7
RIDADR  UN 1170 3/PG 2
WGK Germany  3
RTECS  JX3842500

ANANDAMIDE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0580 Arachidonylethanolamide ≥97.0% (TLC), oil 94421-68-8 5mg $86 2018-11-13 Buy
Sigma-Aldrich A0580 Arachidonylethanolamide ≥97.0% (TLC), oil 94421-68-8 25mg $359 2018-11-13 Buy
Cayman Chemical 90050 Arachidonoyl Ethanolamide ≥98% 94421-68-8 5mg $32 2018-11-13 Buy
Cayman Chemical 90050 Arachidonoyl Ethanolamide ≥98% 94421-68-8 10mg $58 2018-11-13 Buy
Cayman Chemical 10007270 Arachidonoyl Ethanolamide MaxSpec? Standard ≥95% 94421-68-8 100μg $63 2018-11-19 Buy

ANANDAMIDE Chemical Properties,Uses,Production

Uses

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78μM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

Definition

ChEBI: An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.

Hazard

A reproductive hazard.

Biological Activity

Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).

Enzyme inhibitor

This lipid neurotransmitter and endocannabinoid receptor ligand (FW = 347.54 g/mol; CAS 94421-68-8), also known as arachidonylethanolamide, inhibits calcium ion currents and activates the MAP kinase signaling pathway. Anandamide is a naturally occurring effector of central and peripheral nervous systems, as mediated by CB1 and CB2 cannabinoid receptors, respectively. (These receptors were originally characterized as binding Δ9 -tetrahydrocannabinol, or THC, marijuana’s major psychoactive ingredient.) Anandamide, 2-arachidonoylglycerol, and congeners (N- oleoylethanolamide and N-palmitoylethanolamide) are lipophilic signalling molecules with multiple physiological roles in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. Anandamide likewise plays a role in regulating uterine implantation of the early-stage embryo (blastocyst). Anandamide synthesis occurs from N- acetylphosphatidylethanolamine by multiple pathways that include phospholipase A2, phospholipase C, and NAPE-hydrolyzing phospholipase D (or NAPE-PLD). Target(s): adenylate cyclase; Na + channels; a7-nicotinic acetylcholine receptor; 5 HT3 receptors; Ca 2+ channels; K+ channels, voltage-gated; acylglycerol lipase, or monoacylglycerol lipase.

ANANDAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products


ANANDAMIDE Suppliers

Global( 37)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 279 60
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21812 59
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@163.com China 300 58
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13010 57
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 15615 56
Shanghai Kewel Chemical Co., Ltd. +86 (21) 6460-9169
+86 (21) 6460-9160 kewelchemexp@yahoo.com China 9834 50
Chizhou Kailong Import and Export Trade Co., Ltd. Please Email
- xg01_gj@163.com China 9562 50

94421-68-8(ANANDAMIDE)Related Search:


  • n-arachidonoyl-2-hydroxyethylamide
  • ARACHIDONOYL ETHANOLAMIDE
  • ARACHIDONYLETHANOLAMIDE
  • ARACHIDONIC ACID N-[HYDROXYETHYL]AMIDE
  • 5,8,11,14(Z,Z,Z,Z)-EICOSATETRAENOYL 2'-HYDROXYETHYL-AMIDE
  • AEA
  • ANANDAMIDE
  • N-(2-HYDROXYETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
  • N-ARACHIDONOYLETHANOLAMINE
  • Anandamide(inTocrisolveTM100)
  • (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
  • AEA, Anandamide, Arachidonic acid N-(hydroxyethyl)amide
  • 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)-
  • 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-
  • N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)-
  • Arachidonoyl Ethanolamide (in ethanol)
  • Arachidonoyl Ethanolamide MaxSpecStandard
  • Arachidonylethanolamide,AEA, Anandamide, Arachidonic acid N-(hydroxyethyl)amide
  • Anandamide (in Tocrisolve 100)
  • Arachidonoyl Ethanolamide Lipid Maps MS Standard
  • (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
  • ARACHIDONYLETHANOLAMIDE, >=97.0% (TL
  • 11,14-eicosatetraenamide(all-z)-n-(2-hydroxyethyl)-8
  • 14-eicosatetraenamide,n-(2-hydroxyethyl)-(all-z)-11
  • 5,8,11,14-eicosatetraenoylethanolamide
  • anandamide(20.4,n-6)
  • n-(2-hydroxyethyl)anachidonamide
  • 94421-68-8
  • C22H37NO2
  • BioChemical
  • Biochemicals and Reagents
  • Unsaturated fatty acids and derivatives
  • Polyunsaturated
  • Lipids
  • Fatty Acids
  • Fatty acid amides
  • Cannabinoid receptor
  • Cannabinoid
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