ChemicalBook >> CAS DataBase List >>[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
![[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Structure](CAS/GIF/1000669-72-6.gif)
- CAS No.
- 1000669-72-6
- Chemical Name:
- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
- Synonyms
- CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone;Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-
- CBNumber:
- CB72554360
- Molecular Formula:
- C20H20N4O
- Molecular Weight:
- 332.4
- MDL Number:
- MFCD18385006
- MOL File:
- 1000669-72-6.mol
- MSDS File:
- SDS
Last updated:2024-11-06 15:28:16
| Boiling point | 604.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.28 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| pka | 13.76±0.40(Predicted) |
| color | Pale yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| FDA UNII | 2D9N67F58G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22207 | KW 2449 ≥98% | 1000669-72-6 | 5mg | $35 | 2024-03-01 | Buy |
| Cayman Chemical | 22207 | KW 2449 ≥98% | 1000669-72-6 | 10mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 22207 | KW 2449 ≥98% | 1000669-72-6 | 25mg | $149 | 2024-03-01 | Buy |
| Cayman Chemical | 22207 | KW 2449 ≥98% | 1000669-72-6 | 50mg | $263 | 2024-03-01 | Buy |
| AK Scientific | X7371 | (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone | 1000669-72-6 | 50mg | $290 | 2021-12-16 | Buy |
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Uses,Production
Description
KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3
Definition
ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.
target
FLT3
References
Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 106)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29885 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32072 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23025 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-06 | KW-2449
1000669-72-6
|
US $33.00-72.00 / mg | 99.89% | 10g | TargetMol Chemicals Inc. | ||
![[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone pictures](https://img.chemicalbook.com/ProductImageEN/2018-8/Small/cf6c2abb-0cdd-4967-adc4-f75c483f8300.gif) |
2019-07-06 | [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
1000669-72-6
|
US $2000.00-1950.00 / KG | 1KG | 98% | 100kg | Career Henan Chemical Co |
-
- KW-2449
1000669-72-6
- US $33.00-72.00 / mg
- 99.89%
- TargetMol Chemicals Inc.
-
- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
1000669-72-6
- US $2000.00-1950.00 / KG
- 98%
- Career Henan Chemical Co
1000669-72-6([4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone)Related Search:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
KW 2449
(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride
KW-2449;KW 2449; KW2449
[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone
KW-2449 100MG
{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone
3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE
KW2449;KW 2449
CS-468
Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP
KW-2449 hydrochloride HCL
(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
1000669-72-6
Inhibitors
Inhibitor