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Hydroxyprogesterone acetate

Hydroxyprogesterone acetate structure

CAS No.: 302-23-8

Chemical Name:: Hydroxyprogesterone acetate

Synonyms: acetoxyprogesterone;17a-Acetoxyprogesterone;3,20-dioxopregn-4-en-17-yl acetate;17α-hydroxyprogesterone 17-acetate;17-ap;u5533;prodoxacetate;6,7-Dehydro-17αCompound T40380(SC);17α-Acetoxyprogesterone

CBNumber:: CB7502523

Molecular Formula:: C23H32O4

Molecular Weight:: 372.5

MDL Number:: MFCD00021152

MOL File:: 302-23-8.mol

MSDS File:: SDS

Last updated:2026-02-27 08:50:14

Product description	Number	Pack Size	Price
Chlormadinone acetate impurity G European Pharmacopoeia (EP) Reference Standard	Y0001656	25 mg	$162
17ALPHA-ACETOXYPROGESTERONE Aldrich^CPR	S517917	1 unit	$185
17ALPHA-ACETOXYPROGESTERONE Aldrich	S517917	1g	$179
17α-Hydroxyprogesterone 17-acetate ≥98%	A4125	5g	$192
17α-Hydroxyprogesterone Acetate >98.0%(HPLC)	H1527	1g	$49
More product size

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Hydroxyprogesterone acetate Properties

Melting point	249-250°C
Boiling point	421.94°C (rough estimate)
Density	1.0415 (rough estimate)
refractive index	1.4433 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
Water Solubility	1.01mg/L at 20℃
λmax	241nm(EtOH)(lit.)
BRN	2227870
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23+/m1/s1
InChIKey	VTHUYJIXSMGYOQ-KOORYGTMSA-N
SMILES	C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)CC2
CAS DataBase Reference	302-23-8(CAS DataBase Reference)
FDA UNII	L124O66YSI
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H351
Precautionary statements	P280
Hazard Codes	Xn
Risk Statements	40-48
Safety Statements	22-24/25-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	TU5074000
HS Code	29372390
Storage Class	11 - Combustible Solids
Hazard Classifications	Carc. 2

Hydroxyprogesterone acetate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001656	Chlormadinone acetate impurity G European Pharmacopoeia (EP) Reference Standard	302-23-8	25 mg	$162	2025-07-31	Buy
Sigma-Aldrich	S517917	17ALPHA-ACETOXYPROGESTERONE Aldrich^CPR	302-23-8	1 unit	$185	2025-07-31	Buy
Sigma-Aldrich	S517917	17ALPHA-ACETOXYPROGESTERONE Aldrich	302-23-8	1g	$179	2024-03-01	Buy
Sigma-Aldrich	A4125	17α-Hydroxyprogesterone 17-acetate ≥98%	302-23-8	5g	$192	2023-06-20	Buy
TCI Chemical	H1527	17α-Hydroxyprogesterone Acetate >98.0%(HPLC)	302-23-8	1g	$49	2025-07-31	Buy

Product number	Packaging	Price	Buy
Y0001656	25 mg	$162	Buy
S517917	1 unit	$185	Buy
S517917	1g	$179	Buy
A4125	5g	$192	Buy
H1527	1g	$49	Buy

Hydroxyprogesterone acetate Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

An impurity in steroid drug Megestrol acetate (M208050).

Uses

Progesterone Acetate (Megestrol Acetate EP Impurity K) is an impurity in steroid drug Megestrol acetate (M208050).

Synthesis

3beta,17-dihydroxypregn-5-en-20-one 17-acetate 3-formate

83984-86-5

4134-58-1

The general procedure for the synthesis of the target compound (CAS: 4134-58-1) using the compound (CAS: 83984-86-5) as starting material was as follows: the diester (51 g, melting point 192-196°C) was dissolved in a solvent mixture of 1.4 liters of technical grade xylene and 510 ml of cyclohexanone. Water was removed from the system by distillation (250 ml of distillate was collected). Subsequently, aluminum isopropoxide (51 g) dissolved in 210 ml of xylene was added dropwise to the reaction system over a period of 5 minutes under slow distillation conditions, and distillation was continued for 45 minutes (another 210 ml of distillate was collected). Upon completion of the reaction, the mixture was rapidly cooled, the reaction was quenched by the addition of an ice-water mixture, and the remaining solvent was removed by steam distillation. The resulting solid product was collected by filtration and dried. The crude product was extracted using hot acetone and subsequently recrystallized by acetone to give 40.7 g (86% yield) of 17α-acetoxy-progesterone with a melting point of 240-243 °C. The melting point of the further purified sample was raised to 243-247 °C. *The 2% yield of the raw material is equivalent to 78.95%.

References

[1] Patent: EP1359154, 2003, A1. Location in patent: Page/Page column 16; 28; 30; 32
[2] Journal of the American Chemical Society, 1956, vol. 78, p. 820,823

Hydroxyprogesterone acetate Preparation Products And Raw materials

Raw materials

3beta,17-dihydroxypregn-5-en-20-one 17-acetate 3-formate Aluminium isopropoxide Xylene Cyclohexanone

Preparation Products

Hydroxyprogesterone acetate Suppliers

Global( 338)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	admin01@hsnm.com.cn	China	2097	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850 +86-13986145403;	info@fortunachem.com	China	6011	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	870	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	672	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58

Supplier	Advantage
Wuhan Han Sheng New Material Technology Co.，Ltd	58
Hebei Kangcang new material Technology Co., LTD	58
Wuhan Fortuna Chemical Co., Ltd	58
Shaanxi Xianhe Biotech Co., Ltd	58
Wuhan JiyunZen Tech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58

View Lastest Price from Hydroxyprogesterone acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-09	Hydroxyprogesterone acetate 302-23-8	US $0.00 / Kg/Bag	1KG	97%-102%	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-09	Hydroxyprogesterone acetate 302-23-8	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
2026-03-09	17a-hydroxyprogesterone Acetate 302-23-8	US $0.00 / kg	1kg	0.99	1000kg	Shaanxi Xianhe Biotech Co., Ltd

Hydroxyprogesterone acetate
302-23-8
US $0.00 / Kg/Bag
97%-102%
WUHAN FORTUNA CHEMICAL CO., LTD

Hydroxyprogesterone acetate
302-23-8
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

17a-hydroxyprogesterone Acetate
302-23-8
US $0.00 / kg
0.99
Shaanxi Xianhe Biotech Co., Ltd

Hydroxyprogesterone acetate Spectrum

Hydroxyprogesterone acetate(302-23-8)¹HNMR

302-23-8(Hydroxyprogesterone acetate)Related Search:

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5-Chlorovaleric acid Pralmorelin Butyl acetate Vinyl acetate Medroxyprogesterone Acetate

Megestrol acetate Cyproterone acetate Magnesium acetate

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Chlormadinone acetate impurity G 17a- hydroxyprogesterone acetate (monoester) (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tet 17A-HYDROXYPROGESTERONE 17-ACETATE VETRA 17-alpha-Hydroxylprogesterone 17α-acetoxy-4-pregnene-3,20-dione HYDROXYPROGESTERONE, 17a-(RG) 17a-Hydroxy-4-pregnene-3,20-dione acetate 17a-Hydroxyprogesterone acetate Hydroxyprogesterone acetate 17α-Hydroxylprogesterone acetate 17α-Acetoxy-4-pregnene-3,20-dione, 17α-Acetoxyprogesterone, 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate, 4-Pregnen-17α-ol-3,20-dione acetate 17α-Acetoxypregn-4-ene-3,20-dione 17α-Hydroxyprogesterone 17-acetate,17α-Acetoxy-4-pregnene-3,20-dione, 17α-Acetoxyprogesterone, 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate, 4-Pregnen-17α-ol-3,20-dione acetate 17-(Acetyloxy)progesterone 17A-HYDROXYPROGESTERONE 17-ACETATE 17-(acetyloxy)-pregn-4-ene-20-dione 17-ap 20-dione,17-hydroxy-pregn-4-ene-acetate prodoxacetate u5533 Hydroxyprogesterone acetate 17a-Acetoxyprogesterone 17-α-Hydroxyprogesterone Solution, 100ppm 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate Megestrol acetate EP Impurity K Medroxyprogesterone Acetate EP impurity H Megestrol Acetate Impurity 11(Megestrol Acetate EP Impurity K) Chlormadinone acetate impurity G CRS 17α-HydroxyprogesteroneAcetate> Pregn-4-ene-3,20-dione, 17-(acetyloxy)- Chlormadinone Acetate EP Impurity G (8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate 17alpha-Acetoxypregn-4-ene-3,20-dione 17alpha-Hydroxypregn-4-ene-3,20-diene Acetate Hydroxyprogesterone acetate USP/EP/BP 17Α-HYDROXY-PROGESTERONE ACETATE Hydroxyprogesterone acetater TIANFUCHEM--High purity 302-23-8 Hydroxyprogesterone acetate Chlormadinone acetate impurity G (Y0001656) 6-Bromo-6-dehydro-17&alpha 6,7-Dehydro-17&alpha N-(4-ethylsulfonylphenyl)carbamic acid cyclohexyl ester Medroxyprogesterone EP Impurity H Medroxyprogesterone Acetate EP Impurity H (17-alpha-Acetoxy Progesterone) 17a-Hydroxypregn-4-Monoene-3,20-Dione-17-Acetate Hydroxyprogesterone vinegar 3,20-dioxopregn-4-en-17-yl acetate 17α-hydroxyprogesterone 17-acetate 17a-Acetoxyprogesterone acetoxyprogesterone inhibit,17α Hydroxyprogesterone acetate,17αHydroxyprogesterone acetate,17α-Hydroxyprogesterone,Inhibitor 17α-Hydroxyprogesterone acetate (Megestrol Acetate Impurity) seventeen α Hydroxyprogesterone acetate C14241010 17-alpha-HydroxyprogesteronE17-ace Medroxyprogesterone Acetate EP Impurity H (Chlormadinone Acetate EP Impurity G, Megestrol Acetate EP Impurity K, 17-alpha-Acetoxy Progesterone) Rivastigmine Impurity 51 Medroxyprogesterone Acetate Impurity 8 (Medroxyprogesterone Acetate EP Impurity H) 17-alpha-Acetoxy Progesterone (Medroxyprogesterone Acetate EP Impurity H)