Irsogladine maleate
- CAS No.
- 84504-69-8
- Chemical Name:
- Irsogladine maleate
- Synonyms
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber:
- CB8105343
- Molecular Formula:
- C13H11Cl2N5O4
- Molecular Weight:
- 372.16
- MDL Number:
- MFCD00873566
- MOL File:
- 84504-69-8.mol
- MSDS File:
- SDS
Melting point | 181-182°C |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
Water Solubility | Insoluble in water |
solubility |
DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) |
form | White crystalline powder. |
color | White to Almost white |
Merck | 14,5102 |
CAS DataBase Reference | 84504-69-8(CAS DataBase Reference) |
FDA UNII | 66GVU60EPQ |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
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Signal word | Warning | |||||||||
Hazard statements | H361 | |||||||||
Precautionary statements | P201-P202-P281-P308+P313-P405-P501 | |||||||||
RTECS | XY5930000 | |||||||||
HS Code | 2933.69.6050 | |||||||||
Toxicity | LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474) | |||||||||
NFPA 704 |
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Irsogladine maleate price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | I0719 | Irsogladine Maleate >98.0%(HPLC)(T) | 84504-69-8 | 1g | $81 | 2024-03-01 | Buy |
TCI Chemical | I0719 | Irsogladine Maleate >98.0%(HPLC)(T) | 84504-69-8 | 5g | $409 | 2024-03-01 | Buy |
Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 50mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 100mg | $110 | 2024-03-01 | Buy |
Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 250mg | $182 | 2024-03-01 | Buy |
Irsogladine maleate Chemical Properties,Uses,Production
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
An anti-ulcer drug. Potent PDE4 inhibitor
Uses
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 491 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-15319487004 | 1015@dideu.com | China | 2132 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7830 | 58 |
View Lastest Price from Irsogladine maleate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-16 | Irsogladine maleate
84504-69-8
|
US $35.00-25.00 / kg | 1kg | 99.8% | 200tons/year | Sigma Audley | ||
2023-09-20 | Diethyl 2-(4-chlorobenzamido)malonate
84504-69-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2021-07-20 | Irsogladine maleate
84504-69-8
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
- Irsogladine maleate
84504-69-8
- US $35.00-25.00 / kg
- 99.8%
- Sigma Audley
- Diethyl 2-(4-chlorobenzamido)malonate
84504-69-8
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- Irsogladine maleate
84504-69-8
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd