Irsogladine maleate
- CAS No.
- 84504-69-8
- Chemical Name:
- Irsogladine maleate
- Synonyms
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber:
- CB8105343
- Molecular Formula:
- C13H11Cl2N5O4
- Molecular Weight:
- 372.16
- MDL Number:
- MFCD00873566
- MOL File:
- 84504-69-8.mol
- MSDS File:
- SDS
| Melting point | 181-182°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility |
DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) |
| form | White crystalline powder. |
| color | White to Almost white |
| Merck | 14,5102 |
| CAS DataBase Reference | 84504-69-8(CAS DataBase Reference) |
| FDA UNII | 66GVU60EPQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 | |||||||||
| RTECS | XY5930000 | |||||||||
| HS Code | 2933.69.6050 | |||||||||
| Toxicity | LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474) | |||||||||
| NFPA 704 |
|
Irsogladine maleate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | I0719 | Irsogladine Maleate >98.0%(HPLC)(T) | 84504-69-8 | 1g | $81 | 2024-03-01 | Buy |
| TCI Chemical | I0719 | Irsogladine Maleate >98.0%(HPLC)(T) | 84504-69-8 | 5g | $409 | 2024-03-01 | Buy |
| Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 50mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 100mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 30223 | Irsogladine (maleate) | 84504-69-8 | 250mg | $182 | 2024-03-01 | Buy |
Irsogladine maleate Chemical Properties,Uses,Production
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
An anti-ulcer drug. Potent PDE4 inhibitor
Uses
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9231 | 58 |
View Lastest Price from Irsogladine maleate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Irsogladine maleate
84504-69-8
|
US $35.00-25.00 / kg | 1kg | 99.8% | 200tons/year | Sigma Audley | |
 |
2023-09-20 | Diethyl 2-(4-chlorobenzamido)malonate
84504-69-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-02 | Irsogladine maleate
84504-69-8
|
US $24.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD |
-
- Irsogladine maleate
84504-69-8
- US $35.00-25.00 / kg
- 99.8%
- Sigma Audley
-
- Diethyl 2-(4-chlorobenzamido)malonate
84504-69-8
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Irsogladine maleate
84504-69-8
- US $24.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD