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Chlorpheniramine maleate

Chlorpheniramine maleate
Chlorpheniramine maleate structure
CAS No.
113-92-8
Chemical Name:
Chlorpheniramine maleate
Synonyms
Haynon;alunex;piriex;Puermin;c-meton;ibioton;lorphen;piriton;teldrin;Histadur
CBNumber:
CB9142008
Molecular Formula:
C20H23ClN2O4
Formula Weight:
390.86
MOL File:
113-92-8.mol

Chlorpheniramine maleate Properties

Melting point:
130-135 °C (lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Density 
1.1984 (rough estimate)
refractive index 
1.6800 (estimate)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water, soluble in ethanol (96 per cent)
form 
neat
PH
4.0~5.5 (10g/l, 25℃)
Water Solubility 
1-5 g/100 mL at 21 ºC
Merck 
14,2180
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
FDA 21 CFR
310.545; 341.12
FDA UNII
V1Q0O9OJ9Z
ATC code
R06AB04,R06AB54
EPA Substance Registry System
Chlorpheniramine maleate (113-92-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a-P301+P312+P330-P210-P260-P280-P301+P310-P311
Hazard Codes  T,F
Risk Statements  25-39/23/24/25-23/24/25-11
Safety Statements  36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US6504000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333990
Toxicity LD50 orally in mice: 162 mg/kg (Smith)

Chlorpheniramine maleate price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C-036 Chlorpheniramine maleate salt solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material 113-92-8 036-1ml $20.3 2020-08-18 Buy
Sigma-Aldrich C-036 Chlorpheniramine maleate salt solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 113-92-8 1 mL $20.9 2021-03-22 Buy
Sigma-Aldrich 1123000 Chlorpheniramine maleate United States Pharmacopeia (USP) Reference Standard 113-92-8 125mg $297 2021-03-22 Buy
TCI Chemical C0873 Chlorpheniramine Maleate >99.0%(HPLC)(T) 113-92-8 25g $67 2021-03-22 Buy
Alfa Aesar B25238 Chlorpheniramine maleate, 99% 113-92-8 5g $38 2021-03-22 Buy

Chlorpheniramine maleate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

An antagonist of the histamine H1-receptor

Uses

Antihistaminic

brand name

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

General Description

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

General Description

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reactions

Water soluble.

Reactivity Profile

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.

Dosage forms

4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.

Chlorpheniramine maleate Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorpheniramine maleate Suppliers

Global( 433)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Rixing Chemical CO.,LTD
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+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
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18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58

View Lastest Price from Chlorpheniramine maleate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Chlorpheniramine maleate
113-92-8
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-11-30 Chlorpheniramine maleate
113-92-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-19 Chlorpheniramine maleate
113-92-8
US $1.00 / ASSAYS 1ASSAYS 99.99% 500 Metric Ton/Day Handan Tongyi New Material Technology Co., Ltd

Chlorpheniramine maleate Spectrum


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