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Chlorpheniramine maleate

Chlorpheniramine maleate
Chlorpheniramine maleate structure
CAS No.
113-92-8
Chemical Name:
Chlorpheniramine maleate
Synonyms
Haynon;alunex;piriex;Puermin;c-meton;ibioton;lorphen;piriton;teldrin;Histadur
CBNumber:
CB9142008
Molecular Formula:
C20H23ClN2O4
Formula Weight:
390.86
MOL File:
113-92-8.mol

Chlorpheniramine maleate Properties

Melting point:
130-135 °C(lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Density 
1.1984 (rough estimate)
refractive index 
1.6800 (estimate)
Flash point:
9℃
storage temp. 
-20°C Freezer
solubility 
Freely soluble in water, soluble in ethanol (96 per cent)
form 
neat
PH
4.0~5.5 (10g/l, 25℃)
Water Solubility 
1-5 g/100 mL at 21 ºC
Merck 
14,2180
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
EPA Substance Registry System
2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N, N-dimethyl-, (2Z)-2-butenedioate (1:1)(113-92-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,F
Risk Statements  25-39/23/24/25-23/24/25-11
Safety Statements  36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US6504000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 orally in mice: 162 mg/kg (Smith)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Chlorpheniramine maleate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C-036 Chlorpheniramine maleate salt solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material 113-92-8 036-1ml $19.1 2018-11-13 Buy
Sigma-Aldrich 1123000 Chlorpheniramine maleate United States Pharmacopeia (USP) Reference Standard 113-92-8 125mg $280 2018-11-13 Buy
TCI Chemical C0873 Chlorpheniramine Maleate >99.0%(HPLC)(T) 113-92-8 25g $66 2018-11-22 Buy
Alfa Aesar B25238 Chlorpheniramine maleate, 99% 113-92-8 25g $73.1 2018-11-13 Buy
Alfa Aesar B25238 Chlorpheniramine maleate, 99% 113-92-8 5g $34.9 2018-11-13 Buy

Chlorpheniramine maleate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

An antagonist of the histamine H1-receptor

Uses

Antihistaminic

brand name

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

General Description

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

General Description

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reactions

Water soluble.

Reactivity Profile

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Chlorpheniramine maleate Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorpheniramine maleate Suppliers

Global( 283)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Rixing Chemical CO.,LTD
13237129059
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Cangzhou Wanyou New Material Technology Co.,Ltd
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Shanghai Bojing Chemical Co.,Ltd.
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86-0551-65418684 18949823763
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Meihua Biological Technology Co.,Ltd
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View Lastest Price from Chlorpheniramine maleate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-15 Chlorpheniramine maleate
113-92-8
US $1.00 / g 10g 99% 1000 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-03-15 Chlorpheniramine maleate 113-92-8
113-92-8
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-05-24 Chlorpheniramine maleate
113-92-8
US $1.00 / G 1G 99.5% 10000000 Meihua Biological Technology Co.,Ltd

Chlorpheniramine maleate Spectrum


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