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Dibutylamine structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Dibutylamine Properties

Melting point:
−62 °C(lit.)
Boiling point:
159 °C(lit.)
0.767 g/mL at 25 °C(lit.)
vapor density 
4.46 (vs air)
vapor pressure 
1.9 mm Hg ( 20 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
106 °F
storage temp. 
Flammables area
water: soluble3.8g/L at 20°C
11.25(at 21℃)
Weak ammonia.
11.1 (1g/l, H2O, 20℃)
explosive limit
Water Solubility 
4.05 g/L (25 ºC)
Stable. Combustible. Incompatible with strong oxidizing agents, most common metals, strong acids. Vapours may flow over surfaces to a distant source of ignition. Can form explosive mixtures with air.
CAS DataBase Reference
111-92-2(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
1-Butanamine, N-butyl-(111-92-2)
EPA Substance Registry System
Dibutylamine (111-92-2)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H301-H318-H290-H301+H311-H370-H401-H226-H302-H311-H314-H330
Precautionary statements  P233-P234-P240-P241+P242+P243-P264-P270-P271-P273-P301+P330+P331+P310-P303+P361+P353+P310+P363-P305+P351+P338+P310-P307+P311-P390-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P370+P378-P260-P284-P310-P301+P310a-P304+P340-P320-P405-P501a
Hazard Codes  Xn,T
Risk Statements  10-20/21/22-35-23-21/22
Safety Statements  45-36/37/39-28A-26-23
RIDADR  UN 2248 8/PG 2
WGK Germany  1
RTECS  HR7780000
Autoignition Temperature 594 °F
HS Code  2921 19 99
HazardClass  8
PackingGroup  II
Toxicity LD50 orally in rats: 550 mg/kg (Smyth)
NFPA 704
3 0

Dibutylamine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34490 Dibutylamine puriss., ≥99.0% (GC) 111-92-2 500ml-f $34.6 2020-08-18 Buy
Sigma-Aldrich 471232 Dibutylamine ≥99.5% 111-92-2 1l $80.7 2020-08-18 Buy
TCI Chemical D0218 Dibutylamine >99.0%(GC)(T) 111-92-2 25mL $19 2020-06-24 Buy
TCI Chemical D0218 Dibutylamine >99.0%(GC)(T) 111-92-2 500mL $31 2020-06-24 Buy
Alfa Aesar A11671 Di-n-butylamine, 98+% 111-92-2 500ml $33.6 2020-06-24 Buy

Dibutylamine Chemical Properties,Uses,Production

Chemical Properties

colourless liquid with an amine odour

Chemical Properties

Dibutylamine is a colorless liquid with an odor of ammonia.

Chemical Properties

n-Dibutylamine is a strong base and undergoes reactions with acids. It reacts with carbon disulfide and carbon dioxide to form alkyl ammonium salts of dithiocarbamic acid and carbamic acid, respectively.
n-Dibutylamine is nitrosated by nitrite at low pHs to form the mutagenic and carcinogenic product, N-nitrosodibutylamine (Sithole and Guy 1986).


Animal studies have demonstrated that dibutylamine is severely irritating to the eyes. An acute oral rat LD50 value of 550 mg/kg has been reported. The 4 h LC50 in rats is 1150 mg/m3. The 1 h LC50 in rats is >557 ppm.
In a 90 day exposure of rats to 0, 50, 150, or 450 mg/m3, resulted in nasal metaplasia as well as a form of mucous cell hyperplasia.

Production Methods

n-Dibutylamine is prepared by two major methods. The first involves passing ammonia and butanol over an alumina or silica catalyst at a temperature of 300-500°C and under pressure. The second method employs passing ammonia, butanol, and hydrogen over a dehydrogenation catalyst. In each instance the resulting mixtures are separated by continuous distillation and extraction (Schweizer et al 1978). n-Dibutylamine can also be prepared from butyl bromide and ammonia or by reaction of butyl chloride and ammonia (HSDB 1989). The amine also is naturally present in food (Neurath et al 1977) and its emissions are produced in soil and sewage. The amine is also found in the expired air of normal, healthy, nonsmoking adults (Krotoszynski et al 1979).
N-Nitrosamines and their precursors including n-dibutylamine are present in rubber products in which the accelerators and stabilizers used in the vulcanization process were derived from dialkylamines. Analysis of a single extraction of rubber nipples and baby pacifiers with artificial saliva (containing sodium nitrite) showed n-dibutylamine levels up to 3890 p.p.b. and N-nitrosodibutylamine concentrations as high as 427 p.p.b. (Thompson et al 1984).

General Description

A yellow-colored liquid with a amine-like odor. Denser than water. Very corrosive, may burn skin, eyes, and mucous membranes. Flash point 125°F. Combustible. Produce toxic oxides of nitrogen when burned. Used to make other chemicals.

Air & Water Reactions

Flammable. Soluble in water.

Reactivity Profile

Dibutylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Inhalation causes irritation of nose, throat, and lungs; coughing; nausea; headache. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Contact with skin causes irritation and dermatitis.

Health Hazard

n-Dibutylamine is a severe irritant to skin and mucous membranes of the nose, eyes, and respiratory tract. Exposure to this amine may result in some activation of the sympathetic branch of the autonomic nervous system as manifested by elevated blood pressure, eye pupil dilation and flushing of the skin.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: May corrode some metals and attack some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Industrial uses

Primary industrial uses of n-dibutylamine include flotation reagents, dyestuffs, rubber vulcanization accelerators, and corrosion inhibitors (HSDB 1989). In 1985 US production totalled approximately 2000 tons.

Safety Profile

Poison by ingestion and subcutaneous routes. Moderately toxic by skin contact and inhalation. Corrosive. A severe skin and eye irritant. Mutation data reported. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, foam, CO2, dry chemical. Exothermic reaction with cellulose nitrate does not proceed to ignition. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Used as a corrosion inhibitor; and intermediate for emulsifiers, rubber products, dyes; and insecticides.


There is little information available on the absorption, distribution and metabolism of ra-dibutylamine. Aliphatic amines such as dibutylamine are well absorbed from the gut. Both monoamine oxidase and diamine oxidase, which are present in most tissues, are capable of metabolizing many exogenous amines. Although the metabolism of primary amines is more rapid than secondary, the rate of oxidation by the enzyme increases with chain length of the amine, reaching a maximum of five carbon atoms (Beard and Noe 1981). Therefore, n-dibutylamine may be metabolized by these enzyme systems although definitive evidence is lacking.
The highly carcinogenic and mutagenic N-nitrosodibutylamine is formed by reaction of nitrite with n-dibutylamine, the highest rates of nitrosation occurring at low pH (Sithole and Guy 1986). The n-dibutylamine present in ingested foods is nitrosated in the stomach by endogenous nitrite from saliva, etc. together with the sodium nitrite present in some preserved foods to form the highly toxic Nnitrosamine (Airoldi et al 1987). Food additives such as butylated hydroxyanisole inhibited in vitro the nitrosation of n-dibutylamine but this inhibition was not seen in vivo in rats that were given both n-dibutylamine and sodium nitrite.
The endogenous formation of N-nitrosodibutylamine was studied in rats after administration of sodium nitrite or sodium nitrate and n-dibutylamine (Airoldi et al 1984). Urinary excretion of N-nitrosodibutylamine and its metabolites N-butyl- N-(4-hydroxybutyl)-nitrosamine (BBN) and N-butyl-N-(3-carboxypropyl)nitrosamine (BCPN) than was determined. Rats were supplied with 0.2% sodium nitrite or 0.5% sodium nitrate in drinking water and given n-dibutylamine by gavage at 3 doses of 50 mg/kg, 8 h apart. Analysis of the 24 h urine by GC equipped with a thermal energy analyzer failed to detect N-nitrosodibutylamine or its metabolite BBN. However, BCPN was found in the urine of both the sodium nitrite and sodium nitrate groups, indicating that in vivo nitrosation of n-dibutylamine had occurred.


UN2248 Di-n-butylamine, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

Purification Methods

Dry this strong base with LiAlH4, CaH2 or KOH pellets, filter and distil it from BaO or CaH2. [Beilstein 4 IV 550.]


May form explosive mixture with air. Aqueous solution is a strong base. Incompatible with acids, acid chlorides; acid anhydrides; halogens, isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, gly- cols, phenols, cresols, caprolactum solution; strong oxidi- zers; reactive organic compounds. Attacks copper alloys, zinc, tin, tin alloys; galvanized steel. Also, carbon dioxide is listed as incompatible by the state of New Jersey.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Dibutylamine Preparation Products And Raw materials

Raw materials

Preparation Products

Dibutylamine Suppliers

Global( 248)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
13806087780 +86 13806087780 CHINA 17852 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22624 55
career henan chemical co
+86-371-86658258 CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28231 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 10126 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6371 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23045 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 35434 58

View Lastest Price from Dibutylamine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-21 Dibutylamine
US $7.00 / kg 1kg 99% 100kg career henan chemical co

Dibutylamine Spectrum

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