KU-55933
- CAS No.
- 587871-26-9
- Chemical Name:
- KU-55933
- Synonyms
- CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
- CBNumber:
- CB8503709
- Molecular Formula:
- C21H17NO3S2
- Molecular Weight:
- 395.49
- MDL Number:
- MFCD08276985
- MOL File:
- 587871-26-9.mol
- MSDS File:
- SDS
| Boiling point | 628.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.419±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml) |
| pka | 0.33±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| FDA UNII | O549494L5D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
KU-55933 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1109 | KU-55933 ≥98% (HPLC) | 587871-26-9 | 5MG | $103 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1109 | KU-55933 ≥98% (HPLC) | 587871-26-9 | 25MG | $417 | 2024-03-01 | Buy |
| Cayman Chemical | 16336 | Ku-55933 ≥98% | 587871-26-9 | 1mg | $28 | 2024-03-01 | Buy |
| Cayman Chemical | 16336 | Ku-55933 ≥98% | 587871-26-9 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 16336 | Ku-55933 ≥98% | 587871-26-9 | 25 mg | $241 | 2024-03-01 | Buy |
KU-55933 Chemical Properties,Uses,Production
Description
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5
Uses
KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
Uses
A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.
Definition
ChEBI: 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone is a thianthrene.
Biological Activity
Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.
Biochem/physiol Actions
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
storage
Desiccate at -20°C
References
1) Hickson?et al.?(2004),?Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res.,?64?9152 2) Crescenzi?et al.?(2008),?Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res.?14?1877 3) Eaton?et al.?(2007),?Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest.,?117?2723 4) Zhang?et al.?(2015)?The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol.,?91?368 5) Chwastek?et al.?(2017)?The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol.?87?38
KU-55933 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
View Lastest Price from KU-55933 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-08 | KU55933;ku-55933
587871-26-9
|
US $0.00-0.00 / g | 1g | 98%+ | 10kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2019-07-06 | KU-55933
587871-26-9
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- KU55933;ku-55933
587871-26-9
- US $0.00-0.00 / g
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
-
- KU-55933
587871-26-9
- US $2.00 / kg
- 99%
- Career Henan Chemical Co