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Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate
Bis(2-ethylhexyl) phthalate structure
CAS No.
117-81-7
Chemical Name:
Bis(2-ethylhexyl) phthalate
Synonyms
DOP;Behp;DEHP;daf68;DAF 68;di-sec;NLA-20;Octoil;mollano;Fleximel
CBNumber:
CB8708555
Molecular Formula:
C24H38O4
Formula Weight:
390.56
MOL File:
117-81-7.mol

Bis(2-ethylhexyl) phthalate Properties

Melting point:
-50 °C
Boiling point:
386 °C(lit.)
Density 
0.985 g/mL at 25 °C(lit.)
vapor density 
>16 (vs air)
vapor pressure 
1.2 mm Hg ( 93 °C)
refractive index 
n20/D 1.488
Flash point:
405 °F
storage temp. 
2-8°C
solubility 
Miscible with mineral oil and hexane (U.S. EPA, 1985)
form 
Liquid
color 
APHA: ≤10
Odor
Very slight, characteristic.
Water Solubility 
Negligible
FreezingPoint 
<-60℃
Merck 
14,2864
BRN 
1890696
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.1 at 25 °C (calculated, Howard, 1989)
Exposure limits
Potential occupational carcinogen. NIOSH REL: TWA 5, STEL 10, IDLH 5,000; OSHA PEL: TWA 5; ACGIH TLV: TWA 5 (adopted).
CAS DataBase Reference
117-81-7(CAS DataBase Reference)
NIST Chemistry Reference
Bis(2-ethylhexyl)phthalate(117-81-7)
EPA Substance Registry System
1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester(117-81-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  T,F
Risk Statements  60-61-39/23/24/25-23/24/25-11
Safety Statements  53-45-36/37-16
RIDADR  UN 1230 3/PG 2
WGK Germany  1
RTECS  TI0350000
Autoignition Temperature 734 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29173400
Hazardous Substances Data 117-81-7(Hazardous Substances Data)
Toxicity Acute oral LD50 for guinea pigs 26 gm/kg, mice 30 gm/kg, rats 30,600 mg/kg, rabbits 34 gm/kg (quoted, RTECS, 1985).
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
1
0
Health  
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Bis(2-ethylhexyl) phthalate price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 36735 Bis(2-ethylhexyl) phthalate PESTANAL , analytical standard 117-81-7 1g $34.5 2018-11-13 Buy
Sigma-Aldrich 1545056 Plastic additive 14 United States Pharmacopeia (USP) Reference Standard 117-81-7 100mg $348 2018-11-13 Buy
TCI Chemical P0297 Bis(2-ethylhexyl) Phthalate >98.0%(GC) 117-81-7 25g $14 2018-11-22 Buy
TCI Chemical P0297 Bis(2-ethylhexyl) Phthalate >98.0%(GC) 117-81-7 500g $19 2018-11-22 Buy
Alfa Aesar A10415 Bis(2-ethylhexyl) phthalate 98+% 117-81-7 500g $24.2 2018-11-20 Buy

Bis(2-ethylhexyl) phthalate Chemical Properties,Uses,Production

Chemical Properties

Bis(2-ethylhexyl)phthalate is a colorless liquid with a slight odor. It is miscible with mineral oil and hexane, and soluble in most organic solvents. Bis(2-ethylhexyl)phthalate is insoluble in water (NTP, 1994a).

Uses

Dialkyl phthalate ester plasticizer used to import softness and flexibility to PVC products.

Uses

As plasticizer in PVC applications and flexible vinyls.

Uses

Bis(2-ethylhexyl) phthalate is used in vacuum pumps and was formerly employed as a miticide.

Uses

Bis(2-ethylhexyl) phthalate, known by a variety of other names and usually abbreviated DEHP, was patented in 1950 and first used as vacuum pump oil. But since then, it has become the most widely used plasticizer for poly(vinyl chloride) (PVC) and other plastics. Recently, relatively high levels of DEHP have been found in foods, especially foods high in oils and fats. The U.S. Food and Drug Administration now restricts its use in packaging materials to water-based foods. The European Commission has banned the use of DEHP and other phthalates in PVC toys.
Di(2-ethylhexyl)phthalate (DEHP) is a benzenedicarboxilate ester which is the most widely used plasticizer to soften resins. DEHP is hydrolyzed into what many believe to be its toxic metabolite, mono(2-ethylhexyl)phthalate (MEHP), by lipase enzymes in the gastrointestinal tract.

Definition

ChEBI: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.

General Description

Colorless to pale yellow oily liquid. Nearly odorless.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Bis(2-ethylhexyl) phthalate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Incompatible with nitrates .

Health Hazard

Inhalation can cause nausea and irritation of nose and throat. Contact of liquid with eyes or skin causes irritation. Ingestion can cause abdominal cramps, nausea and diarrhea.

Health Hazard

The acute oral toxicity is of extremelylow order. The oral LD50 value in miceis in the range 30,000 mg/kg. Ingestion ofabout 10 mL of the liquid may produce gas trointestinal pain, hypermotility, and diar rhea in humans. Chronic administration byoral route did not produce any adverseeffect in animals. A dose of 100 mg/kg/dayproduced increased liver and kidney weight,as well as retardation of growth in dogs.Mice given diets containing 12,000 ppm ofdiethylhexyl phthalate for 40 weeks devel oped renal hyperplasia (Ward et al. 1988).There was no evidence of renal carcino genicity. Oral administration, however, pro duced tumors in livers in the laboratoryanimals. It is a suspected cancer-causingagent, and there is sufficient evidence of itscarcinogenicity in animals. Such evidence inhumans, however, is lacking
Rock and co-workers (1988) reported theinteraction of diethylhexyl phthalate withblood during storage in PVC plastic containers. The plasticizer is leached into theplasma and converted to mono(2-ethylhexyl)phthalate by a plasma enzyme. At a levelof >125 mg/mL in the blood mono(2-ethyl hexyl) phthalate produced a 50% decrease inheart rate and blood pressure in rats.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental teratogenic data. Other experimental reproductive effects. Poison by intravenous route. Human systemic effects by ingestion: gastrointestinal tract effects. A mild skin and eye irritant. When heated to decomposition it emits acrid smoke.

Potential Exposure

Bis(2-ethylhexyl)phthalate is primarily used as one of several plasticizers in polyvinyl chloride resins used for fabricating flexible vinyl products. It has also been reported as being used as a replacement for polychlorinated biphenyls (PCBs) in dielectric fluids for electric capacitors and in vacuum pumps (NTP, 1994a; Merck, 1989). The primary stationary sources that have reported emissions of bis(2-ethylhexyl)phthalate in California are furniture and fixtures manufacturing, and lumber and wood products manufacturing (ARB, 1997b).

Source

MCLG: zero; MCL: 6 μg/L. In addition, a DWEL of 700 μg/L was recommended (U.S. EPA, 2000).
Detected in distilled water-soluble fractions of new and used motor oil at concentrations of 17–21 and ND-1.2 μg/L, respectively (Chen et al., 1994). Also may leach from plastic products used in analytical laboratories (e.g., tubing, containers).

Environmental Fate

Biological. Bis(2-ethylhexyl) phthalate degraded in both amended and unamended calcareous soils from New Mexico. After 146 d, 76 to 93% degraded (mineralized) to carbon dioxide. No other metabolites were detected (Fairbanks et al., 1985). In a 56-d experiment, [14C]bis(2- ethylhexyl) phthalate applied to soil-water suspensions under aerobic and anaerobic conditions gave 14CO2 yields of 11.6 and 8.1%, respectively (Scheunert et al., 1987).
When bis(2-ethylhexyl) phthalate was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, no degradation was observed after 7 d. In a 21-d period, however, gradual adaptation did occur resulting in 95 and 93% losses at concentrations of 5 and 10 mg/L, respectively (Tabak et al., 1981).
Half-lives of 19 h and 4–5 wk were reported for bis(2-ethylhexyl) phthalate in activated sludge and river water, respectively (Saeger and Tucker, 1976). In sludge-amended agricultural soil, bis(2-ethylhexyl) phthalate (initial concentration 4.1 nmol/g) degraded at a rate of 25.6 pmol/g·day via the intermediate o-phthalic acid. Despite the presence of microorganisms capable of degrading bis(2-ethylhexyl) phthalate, >40% of the bis(2-ethylhexyl) phthalate added was not mineralized after 1 yr (Roslev et al., 1998). Aerobic degradation of bis(2-ethylhexyl) phthalate by acclimated soil and activated sewage sludge microbes was studied using an acclimated shake flask CO2 evolution test. After 28 d, loss of bis(2-ethylhexyl) phthalate (primary degradation) was >99%, with a lag phase of 2.7 d, and ultimate biodegradation (CO2 evolution) was 86%. The half-life under these conditions was 4.55 d (Sugatt et al., 1984).
In the presence of suspended natural populations from unpolluted aquatic systems, the secondorder microbial transformation rate constant determined in the laboratory was reported to be 4.2 ± 0.7 x 10-15 L/organism?h (Steen, 1991). Using the modified Sturm test, >80% of bis(2-ethylhexyl) phthalate mineralized to carbon dioxide in 28 d (Scholz et al., 1997).
Surface Water. In laboratory experiments, the extrapolated volatilization half-life of bis(2- ethylhexyl) phthalate in a stirred water vessel (outer dimensions 22 x 10 x 21 cm) conducted at 22 and 30 °C and an air flow rate of 0.20 m/sec is 3,500 h (Kl?pffer et al., 1982).
Photolytic. The estimated photolytic half-life of bis(2-ethylhexyl) phthalate in water is 143 d (Wolfe et al., 1980).
Chemical/Physical. Hydrolyzes in water to o-phthalic acid (via the intermediate 2-ethyl-hexyl hydrogen phthalate) and 2-ethylhexyl alcohol (Kollig, 1993; Wolfe et al., 1980). Although no pH value was given, the reported hydrolysis rate constant under alkaline conditions is 1,400/M?yr (Ellington et al., 1993; Kollig, 1993). A second-order rate constant of 1.1 x 10-4/M?sec was reported for the hydrolysis bis(2-ethylhexyl) phthalate at 30 °C and pH 8 (Wolfe et al., 1980). Kl?pffer et al. (1982) estimated an evaporation half-life of approximately 140 d from a 21-cm deep vessel.

Metabolism

Bis(2-ethylhexyl) phthalate is metabolized in fish by enzymatic hydrolysis to mono-2-ethylhexyl phthalate, phthalic acid, and glucuronides of these compounds (Stalling et al., 1973).

Purification Methods

Wash the ester with Na2CO3 solution, then shake it with water. After the resulting emulsion has been broken by adding ether, the ethereal solution is washed twice with water, dried (CaCl2), and evaporated. The residual liquid is distilled several times under reduced pressure, then stored in a vacuum desiccator over P2O5 [French & Singer J Chem Soc 1424 1956]. [Beilstein 9 IV 3184.]

Bis(2-ethylhexyl) phthalate Preparation Products And Raw materials

Raw materials

Preparation Products


Bis(2-ethylhexyl) phthalate Suppliers

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View Lastest Price from Bis(2-ethylhexyl) phthalate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-06 Bis(2-ethylhexyl) phthalate
117-81-7
US $1.00 / KG 1KG 98% 1 career henan chemical co
2018-08-06 Bis(2-ethylhexyl) phthalate
117-81-7
US $280.00-280.00 / KG 200KG 99.5% 20T career henan chemical co

Bis(2-ethylhexyl) phthalate Spectrum


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