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디(2-에틸헥실)프탈레이트

디(2-에틸헥실)프탈레이트
디(2-에틸헥실)프탈레이트 구조식 이미지
카스 번호:
117-81-7
한글명:
디(2-에틸헥실)프탈레이트
동의어(한글):
DOP;디(2-에틸헥실)프탈레이트;디옥틸프탈레이트(DOP);디프탈산(D.O.P);비스(2-에틸헥실)프탈레이트;다이에틸헥실프탈레이트;비스(2-에틸헥실)프탈레이트;비스(2-에틸헥실) 프탈레이트
상품명:
Bis(2-ethylhexyl) phthalate
동의어(영문):
DOP;DEHP;Behp;daf68;DAF 68;di-sec;NLA-20;Octoil;mollano;Fleximel
CBNumber:
CB8708555
분자식:
C24H38O4
포뮬러 무게:
390.56
MOL 파일:
117-81-7.mol

디(2-에틸헥실)프탈레이트 속성

녹는점
-50 °C
끓는 점
386 °C (lit.)
밀도
0.985 g/mL at 20 °C (lit.)
증기 밀도
>16 (vs air)
증기압
1.2 mm Hg ( 93 °C)
굴절률
n20/D 1.488
인화점
405 °F
저장 조건
2-8°C
용해도
Miscible with mineral oil and hexane (U.S. EPA, 1985)
물리적 상태
Liquid
색상
APHA: ≤10
냄새
Very slight, characteristic.
수용성
Negligible
어는점
<-60℃
Merck
14,2864
BRN
1890696
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.1 at 25 °C (calculated, Howard, 1989)
노출 한도
Potential occupational carcinogen. NIOSH REL: TWA 5, STEL 10, IDLH 5,000; OSHA PEL: TWA 5; ACGIH TLV: TWA 5 (adopted).
CAS 데이터베이스
117-81-7(CAS DataBase Reference)
IARC
2B (Vol. Sup 7, 77, 101) 2013
NIST
Bis(2-ethylhexyl)phthalate(117-81-7)
EPA
Di(2-ethylhexyl) phthalate (117-81-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F
위험 카페고리 넘버 60-61-39/23/24/25-23/24/25-11
안전지침서 53-45-36/37-16
유엔번호(UN No.) UN 1230 3/PG 2
WGK 독일 1
RTECS 번호 TI0350000
자연 발화 온도 734 °F
TSCA Yes
위험 등급 9
포장분류 III
HS 번호 29173400
유해 물질 데이터 117-81-7(Hazardous Substances Data)
독성 Acute oral LD50 for guinea pigs 26 gm/kg, mice 30 gm/kg, rats 30,600 mg/kg, rabbits 34 gm/kg (quoted, RTECS, 1985).
기존화학 물질 KE-02196
유해화학물질 필터링 2006-1-556
중점관리물질 필터링 별표1-69
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 비스(2-에틸헥실) 프탈레이트 및 이를 25% 이상 함유한 혼합물
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
0

디(2-에틸헥실)프탈레이트 MSDS


Bis(2-ethylhexyl) phthalate

디(2-에틸헥실)프탈레이트 C화학적 특성, 용도, 생산

용도

예전에는 살충제로 사용되었으나 현재는 살충제의 성분으로 사용을 금하고 있는 물질이다. 천연고무나 합성고무의 성분이 되고, 플라스틱 제조 시 가소제로 사용된다. 또한 사진필름이나 케이블이나 전선, 접착제의 성분으로도 사용된다. Bis(2-ethylhexyl)phthalate는 무색의 유성의 액체이고, 약간의 냄새가 나는 물질이다. 또한 혈액이나 지방단백질을 함유한 유체에 용해되는 특성을 가진다.

화학적 성질

Bis(2-ethylhexyl)phthalate is a colorless liquid with a slight odor. It is miscible with mineral oil and hexane, and soluble in most organic solvents. Bis(2-ethylhexyl)phthalate is insoluble in water (NTP, 1994a).

용도

Dialkyl phthalate ester plasticizer used to import softness and flexibility to PVC products.

용도

As plasticizer in PVC applications and flexible vinyls.

용도

Bis(2-ethylhexyl) phthalate is commonly used plasticizing agent for PVCs, which as such is a component of blood bank bags, surgical tubing, and other products including food wrappers and children’s toys.

용도

Bis(2-ethylhexyl) phthalate, known by a variety of other names and usually abbreviated DEHP, was patented in 1950 and first used as vacuum pump oil. But since then, it has become the most widely used plasticizer for poly(vinyl chloride) (PVC) and other plastics. Recently, relatively high levels of DEHP have been found in foods, especially foods high in oils and fats. The U.S. Food and Drug Administration now restricts its use in packaging materials to water-based foods. The European Commission has banned the use of DEHP and other phthalates in PVC toys.
Di(2-ethylhexyl)phthalate (DEHP) is a benzenedicarboxilate ester which is the most widely used plasticizer to soften resins. DEHP is hydrolyzed into what many believe to be its toxic metabolite, mono(2-ethylhexyl)phthalate (MEHP), by lipase enzymes in the gastrointestinal tract.

정의

ChEBI: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.

생산 방법

DEHP is commercially produced via esterification of phthalic acid anhydride and 2-ethylhexanol. Esterification is completed with an acid or metal catalyst or with no catalyst at high temperature.

일반 설명

Colorless to pale yellow oily liquid. Nearly odorless.

공기와 물의 반응

Insoluble in water.

반응 프로필

Bis(2-ethylhexyl) phthalate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Incompatible with nitrates .

건강위험

Inhalation can cause nausea and irritation of nose and throat. Contact of liquid with eyes or skin causes irritation. Ingestion can cause abdominal cramps, nausea and diarrhea.

건강위험

The acute oral toxicity is of extremelylow order. The oral LD50 value in miceis in the range 30,000 mg/kg. Ingestion ofabout 10 mL of the liquid may produce gas trointestinal pain, hypermotility, and diar rhea in humans. Chronic administration byoral route did not produce any adverseeffect in animals. A dose of 100 mg/kg/dayproduced increased liver and kidney weight,as well as retardation of growth in dogs.Mice given diets containing 12,000 ppm ofdiethylhexyl phthalate for 40 weeks devel oped renal hyperplasia (Ward et al. 1988).There was no evidence of renal carcino genicity. Oral administration, however, pro duced tumors in livers in the laboratoryanimals. It is a suspected cancer-causingagent, and there is sufficient evidence of itscarcinogenicity in animals. Such evidence inhumans, however, is lacking
Rock and co-workers (1988) reported theinteraction of diethylhexyl phthalate withblood during storage in PVC plastic containers. The plasticizer is leached into theplasma and converted to mono(2-ethylhexyl)phthalate by a plasma enzyme. At a levelof >125 mg/mL in the blood mono(2-ethyl hexyl) phthalate produced a 50% decrease inheart rate and blood pressure in rats.

화학 반응

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Experimental teratogenic data. Other experimental reproductive effects. Poison by intravenous route. Human systemic effects by ingestion: gastrointestinal tract effects. A mild skin and eye irritant. When heated to decomposition it emits acrid smoke.

잠재적 노출

Bis(2-ethylhexyl)phthalate is primarily used as one of several plasticizers in polyvinyl chloride resins used for fabricating flexible vinyl products. It has also been reported as being used as a replacement for polychlorinated biphenyls (PCBs) in dielectric fluids for electric capacitors and in vacuum pumps (NTP, 1994a; Merck, 1989). The primary stationary sources that have reported emissions of bis(2-ethylhexyl)phthalate in California are furniture and fixtures manufacturing, and lumber and wood products manufacturing (ARB, 1997b).

Carcinogenicity

Di(2-ethylhexyl) phthalate (DEHP) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Source

MCLG: zero; MCL: 6 μg/L. In addition, a DWEL of 700 μg/L was recommended (U.S. EPA, 2000).
Detected in distilled water-soluble fractions of new and used motor oil at concentrations of 17–21 and ND-1.2 μg/L, respectively (Chen et al., 1994). Also may leach from plastic products used in analytical laboratories (e.g., tubing, containers).

환경귀착

Biological. Bis(2-ethylhexyl) phthalate degraded in both amended and unamended calcareous soils from New Mexico. After 146 d, 76 to 93% degraded (mineralized) to carbon dioxide. No other metabolites were detected (Fairbanks et al., 1985). In a 56-d experiment, [14C]bis(2- ethylhexyl) phthalate applied to soil-water suspensions under aerobic and anaerobic conditions gave 14CO2 yields of 11.6 and 8.1%, respectively (Scheunert et al., 1987).
When bis(2-ethylhexyl) phthalate was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, no degradation was observed after 7 d. In a 21-d period, however, gradual adaptation did occur resulting in 95 and 93% losses at concentrations of 5 and 10 mg/L, respectively (Tabak et al., 1981).
Half-lives of 19 h and 4–5 wk were reported for bis(2-ethylhexyl) phthalate in activated sludge and river water, respectively (Saeger and Tucker, 1976). In sludge-amended agricultural soil, bis(2-ethylhexyl) phthalate (initial concentration 4.1 nmol/g) degraded at a rate of 25.6 pmol/g·day via the intermediate o-phthalic acid. Despite the presence of microorganisms capable of degrading bis(2-ethylhexyl) phthalate, >40% of the bis(2-ethylhexyl) phthalate added was not mineralized after 1 yr (Roslev et al., 1998). Aerobic degradation of bis(2-ethylhexyl) phthalate by acclimated soil and activated sewage sludge microbes was studied using an acclimated shake flask CO2 evolution test. After 28 d, loss of bis(2-ethylhexyl) phthalate (primary degradation) was >99%, with a lag phase of 2.7 d, and ultimate biodegradation (CO2 evolution) was 86%. The half-life under these conditions was 4.55 d (Sugatt et al., 1984).
In the presence of suspended natural populations from unpolluted aquatic systems, the secondorder microbial transformation rate constant determined in the laboratory was reported to be 4.2 ± 0.7 x 10-15 L/organism?h (Steen, 1991). Using the modified Sturm test, >80% of bis(2-ethylhexyl) phthalate mineralized to carbon dioxide in 28 d (Scholz et al., 1997).
Surface Water. In laboratory experiments, the extrapolated volatilization half-life of bis(2- ethylhexyl) phthalate in a stirred water vessel (outer dimensions 22 x 10 x 21 cm) conducted at 22 and 30 °C and an air flow rate of 0.20 m/sec is 3,500 h (Kl?pffer et al., 1982).
Photolytic. The estimated photolytic half-life of bis(2-ethylhexyl) phthalate in water is 143 d (Wolfe et al., 1980).
Chemical/Physical. Hydrolyzes in water to o-phthalic acid (via the intermediate 2-ethyl-hexyl hydrogen phthalate) and 2-ethylhexyl alcohol (Kollig, 1993; Wolfe et al., 1980). Although no pH value was given, the reported hydrolysis rate constant under alkaline conditions is 1,400/M?yr (Ellington et al., 1993; Kollig, 1993). A second-order rate constant of 1.1 x 10-4/M?sec was reported for the hydrolysis bis(2-ethylhexyl) phthalate at 30 °C and pH 8 (Wolfe et al., 1980). Kl?pffer et al. (1982) estimated an evaporation half-life of approximately 140 d from a 21-cm deep vessel.

신진 대사

Bis(2-ethylhexyl) phthalate is metabolized in fish by enzymatic hydrolysis to mono-2-ethylhexyl phthalate, phthalic acid, and glucuronides of these compounds (Stalling et al., 1973).

Purification Methods

Wash the ester with Na2CO3 solution, then shake it with water. After the resulting emulsion has been broken by adding ether, the ethereal solution is washed twice with water, dried (CaCl2), and evaporated. The residual liquid is distilled several times under reduced pressure, then stored in a vacuum desiccator over P2O5 [French & Singer J Chem Soc 1424 1956]. [Beilstein 9 IV 3184.]

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