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ML-7 HYDROCHLORIDE

ML-7 HYDROCHLORIDE Structure
ML-7 HYDROCHLORIDE structure
CAS No.
110448-33-4
Chemical Name:
ML-7 HYDROCHLORIDE
Synonyms
ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
CBNumber:
CB9183931
Molecular Formula:
C15H18ClIN2O2S
Molecular Weight:
452.74
MDL Number:
MFCD00065524
MOL File:
110448-33-4.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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ML-7 HYDROCHLORIDE Properties

Melting point 246-249°C dec.
storage temp. -20°C
solubility insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
form powder
color white

SAFETY

Risk and Safety Statements

WGK Germany  3

ML-7 HYDROCHLORIDE price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I2764 ML-7 powder 110448-33-4 5mg $163 2024-03-01 Buy
Sigma-Aldrich 475880 ML-7, Hydrochloride 110448-33-4 1mg $187 2024-03-01 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 5mg $61 2024-03-01 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 1mg $31 2023-06-20 Buy
Cayman Chemical 11801 ML-7 (hydrochloride) ≥95% 110448-33-4 10mg $96 2024-03-01 Buy
Product number Packaging Price Buy
I2764 5mg $163 Buy
475880 1mg $187 Buy
11801 5mg $61 Buy
11801 1mg $31 Buy
11801 10mg $96 Buy

ML-7 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 μM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 .

Chemical Properties

Off-White to Yellow Fine Crystalline Solid

Uses

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Uses

A potent and selective inhibitor of myosin light chain kinase.

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

in vitro

rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].

in vivo

administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].

storage

room temperature (desiccate)

References

[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.

ML-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

ML-7 HYDROCHLORIDE Suppliers

Global( 118)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9425 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TianYuan Pharmaceutical CO.,LTD 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
InvivoChem 		58
Henan Aochuang Chemical Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58

View Lastest Price from ML-7 HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML-7 HYDROCHLORIDE pictures 2022-09-08 ML-7 HYDROCHLORIDE
110448-33-4
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
ML-7 HYDROCHLORIDE pictures 2019-12-24 ML-7 HYDROCHLORIDE
110448-33-4
 US $1.00 / g 1g 99.99% 200kg Career Henan Chemical Co

ML-7 HYDROCHLORIDE Spectrum

ML-7 HYDROCHLORIDE(110448-33-4)1HNMR

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1of4

1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE 1-(5-IODONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE 1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1, ML-7, HCl 1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-*HEX AHYDRO-1,4- 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, hyd Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride 1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride ML 7 hydrochloride, >=98% Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine Monohydrochloride 1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-, Monohydrochloride ML-7 HYDROCHLORIDE ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem ML;ML 7 CS-755 ML7;ML 7 HYDROCHLORIDE ML-7 hydrochloride hydrate ML-7 1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-, hydrochloride (1:1) 110448-33-4 C15H18ClIN2O2S C15H17N2O2ISHCl C15H17IN2O2SHCl Serine/Threonine Kinase Inhibitors Myosin Light Chain Kinase (MLCK) Kinase/Phosphatase Biology BioChemical Cell Biology Cell Signaling and Neuroscience All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators