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Penicillin G sodium salt

Penicillin G sodium salt
Penicillin G sodium salt structure
CAS No.
69-57-8
Chemical Name:
Penicillin G sodium salt
Synonyms
mycofarm;nalpen g;crystapen;Picibanil;penilaryn;novocillin;veticillin;PENICILLIN;pen-a-brasive;PenicinllinG,Na
CBNumber:
CB9211940
Molecular Formula:
C16H17N2NaO4S
Formula Weight:
356.37
MOL File:
69-57-8.mol

Penicillin G sodium salt Properties

Melting point:
209-212°C
alpha 
D24.8 +301° (c = 2.0 in water)
Density 
1.41
refractive index 
300 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.
form 
powder
color 
colorless or white
PH
5.5-7.5 (3% in H2O)
Water Solubility 
5-10 g/100 mL at 25 ºC
Merck 
14,7094
BRN 
3834217
Stability:
Stability Stable, but incompatible with a wide variety of materials, including acids, oxidizing agents, heavy metals, alcohols, glycerol, thiomersal, many surface-active agents, alkalies, peroxides, reducing agents, lanolin, glycol, sugars, amines, iodine, iodides, thiols. Hygroscopic.
CAS DataBase Reference
69-57-8(CAS DataBase Reference)
EPA Substance Registry System
Penicillin G sodium (69-57-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Hazard statements  H317-H334
Precautionary statements  P261-P280g-P284-P304+P340-P342+P311a-P501a
Hazard Codes  Xn,Xi
Risk Statements  42/43
Safety Statements  22-36/37-45
WGK Germany  2
RTECS  XH9800000
10-23
HS Code  29411000
Toxicity LD50 oral in rat: 6916mg/kg

Penicillin G sodium salt price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P3032 Penicillin G sodium salt powder, BioReagent, suitable for cell culture 69-57-8 1mu $16.7 2019-12-02 Buy
Sigma-Aldrich 1502701 Penicillin G sodium United States Pharmacopeia (USP) Reference Standard 69-57-8 150mg $362.6 2019-12-02 Buy
TCI Chemical P1770 Penicillin G Sodium Salt >98.0%(HPLC)(N) 69-57-8 1g $40 2019-12-02 Buy
TCI Chemical P1770 Penicillin G Sodium Salt >98.0%(HPLC)(N) 69-57-8 5g $138 2019-12-02 Buy
Alfa Aesar J63032 Penicillin G sodium salt 69-57-8 5g $16.4 2019-12-02 Buy

Penicillin G sodium salt Chemical Properties,Uses,Production

Chemical Properties

White powder

History

Penicillin was discovered by chance in 1928 by Alexander Fleming. He observed that the growth of a bacteria culture was inhibited by a fungus Penicillum notatum. He published his results but did not pursue its industrial development actively. Ten years later, H. Florey and coworkers had produced enough purified penicillin to treat just one patient. This test, however, was sufficient to prove that it was a viable drug. From then on many people and companies participated in the development of new fermentation technologies, new microorganisms, new downstream processing, and so on to make a large-scale production possible. Penicillin did not only change the medical world, but also the fermentation technology. The naturally growing (wild type) Penicillum notatum produced penicillin with a yield of 10 mg/L. Therefore, the first task was the search for a more productive species. Eventually, Penicillium chrysogenum was identified as the most productive species. To enhance penicillin production further, the old method of growing Penicillum mold on the surface of the medium in liter-sized flasks was replaced by fermentation in large aerated tanks. This allowed the mold to grow throughout the entire tank and not just on the surface of the medium. Today, penicillin and other antibiotics are produced in large-scale fermenters holding several hundred cubic meters of medium and the yield has increased 5000 fold to 50 g/L.

Uses

Sodium salt of Penicillin G, an antibacterial, antimicrobial medication. Used in the treatment of pneumococcus and streptococcus bacterial infections.

Definition

penicillin: An antibiotic derivedfrom the mould Penicillium notatum;specifically it is known as penicillin Gand belongs to a class of similar substancescalled penicillins. They producetheir effects by disruptingsynthesis of the bacterial cell wall,and are used to treat a variety of infectionscaused by bacteria.

brand name

Bicillin all purpose;Ceilipen;Cidan-cilina;Cilipen;Coliriocilina;Crisocilin-g;Crystamycin;Crystapen g;Demosa casi penicilina;Dermosa cusipenicilina;Falaper;Gonoper;Hormocillin forte;Ilcocillin;Juvanesta;Lasacilina;Liademycin;M-cillin b;Monocillin;Natricilin;P.g.a.;Paclia g;Patosica;Penibiot;Penicilina klari;Penilevel;Penimiluy;Peniroger;Penitasa "450" simple;Sancilin;Saniciline;Servipan;Sk-penicillin g;Sodiopen;Sodipen;Tabillin;Therapen-na;Triplopen;Unicilina sodia.

World Health Organization (WHO)

Penicillin is listed separately in the WHO Model List of Essential Drugs.

World Health Organization (WHO)

WHO Comment(Benzylpenicillin sodium topical preparations): Benzylpenicillin sodium, one of the first penicillin derivatives to be used in medicine, was introduced in the early 1940s. Topical preparations intended for use on the skin have been associated with allergic rashes and are in general no longer acceptable. However, topical preparations for specialized use, in particular in the eye and on open wounds, are available in many countries. Injectable preparations of benzylpenicillin are included in the WHO Model List of Essential Drugs.

General Description

White to slightly yellow crystalline powder with a faint odor. pH (10% solution) 5.5-7.5.

Air & Water Reactions

Water soluble.

Reactivity Profile

Penicillin G sodium salt is hygroscopic. Penicillin G sodium salt is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. Penicillin G sodium salt is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. Penicillin G sodium salt may also be incompatible with naphthalene oils and vitamin B.

Fire Hazard

Flash point data for Penicillin G sodium salt are not available; however, Penicillin G sodium salt is probably combustible.

Purification Methods

Purify the salt by dissolving it in a small volume of MeOH (in which it is more soluble than EtOH) and treating gradually with ~5 volumes of EtOAc. This gives an almost colourless crystalline solid (rosettes of clear-cut needles) and recrystallising twice more if slightly yellow in colour. The salt has also been conveniently recrystallised from the minimum volume of 90% Me2CO and adding an excess of absolute Me2CO. A similar procedure can be used with wet n-BuOH. If yellow in colour, then dissolve (~3.8g) in the minimum volume of H2O (3mL), add n-BuOH and filter through a bed of charcoal. The salt forms long white needles on standing in a refrigerator overnight. More crystals can be obtained on concentrating the mother liquors in vacuo at 40o. A further recrystallisation (without charcoal) yields practically pure salt. A good preparation has ~600 Units/mg. The presence of H2O in the solvents increases the solubility considerably. The solubility in mg/100mL at 0o is 6.0 (Me2CO), 15.0 (Me2CO/0.5% H2O), 31.0 (Me2CO/1.0% H2O), 2.4 (methyl ethyl ketone), 81.0 (n-butanol) and 15.0 (dioxane at 14o). Alternatively it is dissolved in H2O (solubility is ~10%), filtered if necessary and precipitated by addition of EtOH and dried in a vacuum over P2O5. A sample can be kept for 24hours at 100o without loss of physiological activity. It also crystallises from MeOH/EtOAc. [IR: Barnes et al. Anal Chem 19 620 1947, The Chemistry of Penicillin (Clarke, Johnson and Robinson eds.) Princeton University Press, Princeton NJ, Chapter V 85 1949, Beilstein 27 III/IV 5861.]

Penicillin G sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products


Penicillin G sodium salt Suppliers

Global( 229)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21792 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 569 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30057 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28235 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58

View Lastest Price from Penicillin G sodium salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Penicillin G sodium salt
69-57-8
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-09-21 Pharmaceutical Intermediate Powder Penicillin G Sodium Salt CAS: 69-57-8
69-57-8
US $10.00 / G 10G 99% 100MT Hubei XinRunde Chemical Co., Ltd.

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