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Cellulose acetate phthalate

Cellulose acetate phthalate
Cellulose acetate phthalate structure
Chemical Name:
Cellulose acetate phthalate
cap-wako;CELLACEFATE;cellacetate;CELLACEFATE,NF;celluloseacetophthalate;acetylphthalylcellulose;celluloseacetylphthalate;ELLULOSE ACETATE PHTHALATE;CELLULOSE ACETATE PHTHALATE;celluloseacetatemonophthalate
Molecular Formula:
Formula Weight:
MOL File:
Mol file

Cellulose acetate phthalate Properties

Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
EPA Substance Registry System
Cellulose, acetate hydrogen 1,2-benzenedicarboxylate(9004-38-0)


Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  FJ5692000
HS Code  39129010

Cellulose acetate phthalate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001054 Cellulose acetate phthalate European Pharmacopoeia (EP) Reference Standard 9004-38-0 y0001054 $179 2018-11-23 Buy
Sigma-Aldrich 1098355 Cellulose acetate phthalate 9004-38-0 125mg $311.15 2018-11-20 Buy

Cellulose acetate phthalate Chemical Properties,Uses,Production

Chemical Properties

white granular powder

Chemical Properties

Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.


Enteric coating in pharmaceutical products.

Production Methods

Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.

Pharmaceutical Applications

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.
Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone.
Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations.
Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

Safety Profile

An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.


Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.


Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.


Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cellulose acetate phthalate Preparation Products And Raw materials

Raw materials

Preparation Products

Cellulose acetate phthalate Suppliers

Global( 65)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23982 58
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3580 66
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 China 9851 79
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 China 9409 52
Beijing Taiya Jie Technology Development Co., Ltd. 13552411790、010-56275498QQ:1904959239
010-84817120 China 1516 55
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 China 9916 55
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email China 12128 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 24991 65

Cellulose acetate phthalate Spectrum

9004-38-0(Cellulose acetate phthalate)Related Search:

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