ChemicalBook
Chinese english Germany Japanese Korea

Cellulose acetate phthalate Produkt Beschreibung

Cellulose acetate phthalate Struktur
9004-38-0
CAS-Nr.
9004-38-0
Englisch Name:
Cellulose acetate phthalate
Synonyma:
cap-wako;CELLACEFATE;cellacetate;CELLACEFATE,NF;celluloseacetophthalate;acetylphthalylcellulose;celluloseacetylphthalate;ELLULOSE ACETATE PHTHALATE;CELLULOSE ACETATE PHTHALATE;celluloseacetatemonophthalate
CBNumber:
CB9396579
Summenformel:
C116H116O64
Molgewicht:
2534.12
MOL-Datei:
Mol file

Cellulose acetate phthalate Eigenschaften

Löslichkeit
Practically insoluble in water, freely soluble in acetone, soluble in diethylene glycol, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides
Aggregatzustand
neat
EPA chemische Informationen
Cellulose, acetate hydrogen 1,2-benzenedicarboxylate(9004-38-0)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22-36/37/38
S-Sätze: 24/25-36-26
WGK Germany  3
RTECS-Nr. FJ5692000
HS Code  39129010

Cellulose acetate phthalate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Cellulose acetate phthalate is a hygroscopic, white to off-white, freeflowing powder, granule, or flake. It is tasteless and odorless, or might have a slight odor of acetic acid.

Chemische Eigenschaften

white granular powder

Verwenden

Enteric coating in pharmaceutical products.

Vorbereitung Methode

Cellulose acetate phthalate is produced by reacting the partial acetate ester of cellulose with phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid.

Pharmazeutische Anwendungen

Cellulose acetate phthalate (CAP) is used as an enteric film coating material, or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment.
Cellulose acetate phthalate is commonly applied to solid-dosage forms either by coating from organic or aqueous solvent systems, or by direct compression. Concentrations generally used are 0.5–9.0% of the core weight. The addition of plasticizers improves the water resistance of this coating material, and formulations using such plasticizers are more effective than when cellulose acetate phthalate is used alone.
Cellulose acetate phthalate is compatible with many plasticizers, including acetylated monoglyceride; butyl phthalybutyl glycolate; dibutyl tartrate; diethyl phthalate; dimethyl phthalate; ethyl phthalylethyl glycolate; glycerin; propylene glycol; triacetin; triacetin citrate; and tripropionin. It is also used in combination with other coating agents such as ethyl cellulose, in drug controlledrelease preparations.
Therapeutically, cellulose acetate phthalate has recently been reported to exhibit experimental microbicidal activity against sexually transmitted disease pathogens, such as the HIV-1 retrovirus.

Sicherheitsprofil

An experimental teratogen. When heated to decomposition it emits acrid smoke and irritating fumes.

Sicherheit(Safety)

Cellulose acetate phthalate is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material, free of adverse effects. Results of long-term feeding in rats and dogs have indicated a low oral toxicity. Rats survived daily feedings of up to 30% in the diet for up to 1 year without showing a depression in growth. Dogs fed 16 g daily in the diet for 1 year remained normal.

Lager

Slow hydrolysis of cellulose acetate phthalate will occur under prolonged adverse conditions such as high temperatures and high humidity, with a resultant increase in free acid content, viscosity, and odor of acetic acid. However, cellulose acetate phthalate is stable if stored in a well-closed container in a cool, dry place.

Inkompatibilitäten

Cellulose acetate phthalate is incompatible with ferrous sulfate, ferric chloride, silver nitrate, sodium citrate, aluminum sulfate, calcium chloride, mercuric chloride, barium nitrate, basic lead acetate, and strong oxidizing agents such as strong alkalis and acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cellulose acetate phthalate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cellulose acetate phthalate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 67)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23959 58
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3579 66
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9406 52
Beijing Taiya Jie Technology Development Co., Ltd. 13552411790、021-37288178 QQ:1904959239 / 2938065042
021-37288178 E-mail:postmaster@tyjchem.cn China 1496 55
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12126 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 24991 65

9004-38-0()Verwandte Suche:


  • ELLULOSE ACETATE PHTHALATE
  • Cellulose Acetate Phthalate (CAP)
  • Cellulose Acetate Phthalate API
  • Cellulose acetate phthalate NF
  • celluloseacetophthalate
  • celluloseacetylphthalate
  • CELLACEFATE
  • Cellulose acetate hydrogen 1,2-benzenedicarboxylate
  • CELLULOSE ACETATE HYDROGEN PHTHALATE
  • CELLULOSE ACETATE PHTHALATE
  • CelluloseAcetatePhthalate(Cellacefate)
  • Cellulose acetate hydrogen phthalate, acetyl content 17.0-22.0%
  • CELLACEFATE,NF
  • CELLULOSE ACETATE PHTHALATE extrapure
  • Cellacefate (125 mg) (Cellulose Acetate Phthalate)
  • acetylphthalylcellulose
  • cap-wako
  • cellacetate
  • -
  • Cation
  • Cellulose
  • LPLC Separation Media
  • 9004-38-0
  • C116H116O64
  • C8H6O4xC2H4O2xW99
  • LPLC/TLC/Paper Chromatography
  • LPLC Separation Media
  • Cation
  • Cellulose
  • Analytical Chromatography Product Catalog
  • celluloseacetatemonophthalate
Copyright 2019 © ChemicalBook. All rights reserved