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Ethyl cellulose

CAS No.
9004-57-3
Chemical Name:
Ethyl cellulose
Synonyms
ets;ethocel;MODIFIED CELLULOSE;g50;t100;g200;spt50cps;nixone/c;aquacoat;ethocele7
CBNumber:
CB6165620
Molecular Formula:
C23H24N6O4
Molecular Weight:
448.47446
MDL Number:
MFCD00131037
MOL File:
9004-57-3.mol
Last updated:2023-11-28 16:31:43

Ethyl cellulose Properties

Melting point 240-255 °C
Density 1.14 g/mL at 25 °C (lit.)
refractive index n20/D 1.47(lit.)
storage temp. 2-8°C
solubility esters, aromatic hydrocarbons, alcohols and ketones: soluble
form powder
color White to slightly yellow
Specific Gravity 1.14
Viscosity 18-22 cps
Water Solubility insoluble
Merck 14,3781
Dielectric constant 2.8(Ambient)
FDA 21 CFR 172.868; 573.420; 175.300; 182.90; 73.1; 73.1001
Substances Added to Food (formerly EAFUS) ETHYL CELLULOSE
SCOGS (Select Committee on GRAS Substances) Ethyl cellulose (packaging)
NCI Dictionary of Cancer Terms ETS
FDA UNII ETHYLCELLULOSE HIGH-SUBSTITUTED (10 MPA.S) (19B35R0C0W)
ETHYLCELLULOSE (100 MPA.S) (47MLB0F1MV)
ETHYLCELLULOSE (10 MPA.S) (3DYK7UYZ62)
ETHYLCELLULOSE (14 MPA.S) (589D1IWM11)
ETHYLCELLULOSE (50 MPA.S) (6I475159RA)
EPA Substance Registry System Ethyl cellulose (9004-57-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H313-H319-H315-H303-H335-H412
Precautionary statements  P312-P312-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P273-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  FJ5950500
3
Autoignition Temperature 698 °F
TSCA  Yes
HS Code  39129000
NFPA 704
1
0 0

Ethyl cellulose price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46080 Ethyl cellulose 48.0-49.5% (w/w) ethoxyl basis 9004-57-3 250g $145 2024-03-01 Buy
Sigma-Aldrich 46080 Ethyl cellulose 48.0-49.5% (w/w) ethoxyl basis 9004-57-3 1kg $471 2024-03-01 Buy
Sigma-Aldrich 46070 Ethyl cellulose 48.0-49.5% (w/w) ethoxyl basis 9004-57-3 250g $228 2024-03-01 Buy
Sigma-Aldrich 46070 Ethyl cellulose 48.0-49.5% (w/w) ethoxyl basis 9004-57-3 1kg $467 2024-03-01 Buy
Sigma-Aldrich 200646 Ethyl cellulose viscosity 4 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl 9004-57-3 250g $293 2024-03-01 Buy
Product number Packaging Price Buy
46080 250g $145 Buy
46080 1kg $471 Buy
46070 250g $228 Buy
46070 1kg $467 Buy
200646 250g $293 Buy

Ethyl cellulose Chemical Properties,Uses,Production

Chemical Properties

Ethylcellulose is a tasteless, free-flowing, white to light tan-colored powder.

Chemical Properties

white to slightly yellowish powder

Chemical Properties

Ethyl celluloses are low density polymers (1070–1180 kg.m–3) with solubilities depending on the degree of ethylation; usually commercial grade contains 44–48% ethoxyl functional groups. Solid masses of ethylcellulose exhibit low absorption of moisture, excellent dimensional stability and low temperature toughness and impact resistance. Chemically they are less resistant towards acids than cellulose esters but much more resistant to alkalis. They can be processed by injection molding. Because ethylcellulose is soluble in a wide variety of solvents, it provides a wide variety of varnish formulations. Benzylcelluloses yield plastics with excellent dielectric properties and chemical stability.

Uses

In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder).

Uses

ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose.

Uses

Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates.

Uses

Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit.

Preparation

Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl.
Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures.

Production Methods

Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical:
RONa + C2H5Cl→ROC2H5+NaCl
The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three.

Definition

ChEBI: Ethyl cellulose is a glycoside.

brand name

Aquacoat ECD (FMC);Ethocel (Dow Chemical).

Pharmaceutical Applications

Ethylcellulose is widely used in oral and topical pharmaceutical formulations.
The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former.
Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression.
High-viscosity grades of ethylcellulose are used in drug microencapsulation.
Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area.
In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution.
Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances.
In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions.
Ethylcellulose is additionally used in cosmetics and food products.

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys.
Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material.
As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet.
LD50 (rabbit, skin): >5 g/kg
LD50 (rat, oral): >5 g/kg

storage

Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters.
Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range.
Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents.

Incompatibilities

Incompatible with paraffin wax and microcrystalline wax.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethyl cellulose Preparation Products And Raw materials

Global( 487)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024 hibo06@xaltbio.com China 1000 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 admin@hbjingbo.cn China 1000 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998 sales@czwytech.com CHINA 906 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

View Lastest Price from Ethyl cellulose manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL CELLULOSE pictures 2024-03-19 ETHYL CELLULOSE
9004-57-3
US $40.00 / KG 1KG 99 10000 kilograms/ month Hebei Yime New Material Technology Co., Ltd.
Ethyl cellulose pictures 2023-12-25 Ethyl cellulose
9004-57-3
US $5.00 / kg 1kg 99% 200000 Hebei Jingbo New Material Technology Co., Ltd
Ethyl cellulose pictures 2023-11-08 Ethyl cellulose
9004-57-3
US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
  • ETHYL CELLULOSE pictures
  • ETHYL CELLULOSE
    9004-57-3
  • US $40.00 / KG
  • 99
  • Hebei Yime New Material Technology Co., Ltd.
  • Ethyl cellulose pictures
  • Ethyl cellulose
    9004-57-3
  • US $5.00 / kg
  • 99%
  • Hebei Jingbo New Material Technology Co., Ltd
  • Ethyl cellulose pictures
  • Ethyl cellulose
    9004-57-3
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
ampacete/c aquacoat aquacoatecd30 aquacoatecd30fmc cellulose,triethylether celluloseethyl nixone/c spt50cps t100(polysaccharide) triethylcellulose Ethyl Cellulose [9-11mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C] Ethyl Cellulose [45-55mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C] Ethyl Cellulose [90-110mPa.s, 5% in Toluene + Ethanol (80:20) at 25deg C] CELLULOSE ETHYL ETHER 'ETHOCEL'(R) ETHYL CELLULOSE ETHYL CELLULOSE 10 ETHYL CELLULOSE 100 ETHYL CELLULOSE 45 ETHYL CELLULOSE 50 Ethylcellulose M9 Ethyl Cellulose, Ethoxyl Content 2-[butyl({4-[(E)-2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]-3-Methylphenyl})aMino]ethyl acetate Ethyl cellulose, ethoxyl content 48%, 22 cps 500GR Ethyl cellulose,Ethylcellulosum Ethyl cellulose,Ethocel Ethylcellulose (1 g) Ethyl cellulose USP Ethyl cellulose, 5% solution in toluene/ethanol (4/1), ethoxyl content 48%, 10 cps Ethyl cellulose viscosity 10 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl Ethyl cellulose viscosity 100 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl Ethyl cellulose viscosity 22 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl Ethyl cellulose viscosity 46 cP, 5 % in toluene/ethanol 80:20(lit.), extent of labeling: 48% ethoxyl EC/Ethyl cellulose EC)Ethyl cellu MODIFIED CELLULOSE, EC Ethylcellulose 7 mPa s ETHYL CELLULOSE 3-5.5 MPA.S ETHYL CELLULOSE, 140-180 MPA.S* ETHYL CELLULOSE, ETHOXYL CONTENT 48%, VI SCOSITY 46 CPS ETHYL CELLULOSE, 18-22 MPA.S ETHYL CELLULOSE, 10 CPS ETHYL CELLULOSE, 45-55 MPA.S Ethyl cellulose, 30-60 mPa.s ETHYL CELLULOSE, 80-120 MPA.S* ETHYL CELLULOSE, 5-15 MPA.S ETHYL CELLULOSE, PH EUR ETHYL CELLULOSE, 180-220 MPA.S ETHYL CELLULOSE, 9-11 MPA.S ETHYL CELLULOSE, 90-110 MPA.S Ethylcellulose 45 mPa s Ethylcellulose(Ec) EthylCellulose(Ec),EthoxylContent47.5%Min. ETHYL CELLULOSE (22 N) Ethyl cellulose, ethoxyl content 46%, 100 cps Ethyl cellulose, ethoxyl content 48%, 10 cps Ethyl cellulose, ethoxyl content 48%, 100 cps Ethyl cellulose, ethoxyl content 48%, 22 cps