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Doxylamine succinate

Chemical Name:
Doxylamine succinate
unisom;decapryn;hoggarn;gittalun;sedaplus;alsadorm;mereprine;DoxylaMineSuccinat;Decapryn succinate;DOXYLAMINE SUCCINATE
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2024-03-28 13:39:29

Doxylamine succinate Properties

Melting point 95-98?C
Flash point 9℃
storage temp. 2-8°C
solubility Very soluble in water, freely soluble in ethanol (96 per cent).
color White to Off-White
Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
LogP 2.519 (est)
FDA 21 CFR 341.12
CAS DataBase Reference 562-10-7(CAS DataBase Reference)
IARC 3 (Vol. 79) 2001
EPA Substance Registry System Doxylamine succinate (1:1) (562-10-7)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H302+H312+H332-H335
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn,T,F
Risk Statements  22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  26-36/37-45-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  US9275000
HS Code  2933399090
Toxicity LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)
NFPA 704
3 0

Doxylamine succinate price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D-045 Doxylamine succinate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 562-10-7 1mL $50 2024-03-01 Buy
Sigma-Aldrich 1227006 Doxylamine succinate United States Pharmacopeia (USP) Reference Standard 562-10-7 300mg $436 2024-03-01 Buy
TCI Chemical D5583 Doxylamine Succinate 562-10-7 5G $32 2024-03-01 Buy
TCI Chemical D5583 Doxylamine Succinate 562-10-7 25G $96 2024-03-01 Buy
Cayman Chemical 21826 Doxylamine (succinate) ≥98% 562-10-7 1mg $41 2024-03-01 Buy
Product number Packaging Price Buy
D-045 1mL $50 Buy
1227006 300mg $436 Buy
D5583 5G $32 Buy
D5583 25G $96 Buy
21826 1mg $41 Buy

Doxylamine succinate Chemical Properties,Uses,Production

Chemical Properties

white to light cream powder


Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.


antihistaminic, hypnotic


H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.


ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Doxylamine succinate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 333)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd
+8618928027945 China 97 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 China 6011 58
Hebei Kangcang new material Technology Co., LTD
+8615713292910 China 341 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21689 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 China 9341 55
+undefined-21-51877795 China 32686 60
career henan chemical co
+86-0371-86658258 China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 CHINA 28180 58
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538 China 321 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953 China 2995 58

View Lastest Price from Doxylamine succinate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
US $20.00-10.00 / kg 1kg 98% 20 Hebei Kangcang new material Technology Co., LTD
Doxylamine succinate pictures 2023-10-09 Doxylamine succinate
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
Doxylamine succinate pictures 2023-09-08 Doxylamine succinate
US $0.00 / KG Ton 1KG Ton 98%+ 2 tons/month Zhuhai Hairuide Bioscience and Technology Co., Ltd
  • Doxylamine succinate pictures
  • Doxylamine succinate
  • US $0.00 / KG Ton
  • 98%+
  • Zhuhai Hairuide Bioscience and Technology Co., Ltd

Doxylamine succinate Spectrum

Doxylaminhydrogensuccinat N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate DOXLAMINE SUCCINATE USP [(3-carboxypropanoyl)oxy]diMethyl{2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethyl}aMinyl Butanedioic acid, compd. with N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1) Doxylamine for system suitability Doxylamine succinate solution doxylaminesuccinate(1:1) gittalun hoggarn mereprine phenyl2-pyridylmethyl-beta-n,n-dimethylaminoethylethersuccinate sedaplus N,N-DIMETHYL-2-[1-PHENYL-1-(2-PYRIDINYL)ETHOXY]ETHENAMINE SUCCINATE LABOTEST-BB LT00244822 DOXYLAMINE SUCCINATE DOXYLAMINE SUCCINATE SALT 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1 2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate 2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate alsadorm decarpynsuccinate(1:1) dimethylaminoethoxy-methyl-benzyl-pyridinesuccinate DoxylaMineSuccinat Doxylamine Succinate (300 mg) Decapryn succinate DOXYLAMINESUCCINATE,USP N,N-dimethyl-2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethanamine Doxylamine hydrogen succinate CRS Doxylamine for system suitability CRS Doxylaminesuccinatesal N,N-Dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine Succinate Doxylamine succinate USP/EP/BP doxl amine succinate Doxylamine succinateQ: What is Doxylamine succinate Q: What is the CAS Number of Doxylamine succinate Q: What is the storage condition of Doxylamine succinate Q: What are the applications of Doxylamine succinate Doxylamine Succinate (1227006) unisom decapryn Docylamine succinate N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine (Doxylamine succinate) 562-10-7 C17H22N2OC4H6O4 API DECAPRYN Other APIs Antagonists Histaminergics Neurotransmitters Amines Aromatics Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals