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Gluconic acid

Description References
Gluconic acid
Gluconic acid structure
Chemical Name:
Gluconic acid
gluconic;glosanto;NSC 77381;glyconicacid;Hexonic acid;GLUCONIC ACI;Glyconic acid;d-gluconicaci;dextronicacid;MALTONIC ACID
Molecular Formula:
Formula Weight:
MOL File:

Gluconic acid Properties

Melting point:
15 °C
Boiling point:
102 °C
D20 -6.7° (c = 1)
refractive index 
storage temp. 
Store at RT.
Crystalline Powder or Crystals
pK (25°) 3.60
White to light yellow
Specific Gravity
optical activity
[α]/D +9.0 to 15.5°
Water Solubility 
Soluble in water.
CAS DataBase Reference
526-95-4(CAS DataBase Reference)
NIST Chemistry Reference
Gluconic acid(526-95-4)
EPA Substance Registry System
D-Gluconic acid(526-95-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,C
Risk Statements  36/37/38-34
Safety Statements  37/39-26-45-36/37/39
RIDADR  3265
WGK Germany  -
RTECS  LZ5057100
HazardClass  8
PackingGroup  III
HS Code  29181600
Hazardous Substances Data 526-95-4(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Gluconic acid price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G1951 D-Gluconic acid solution 49-53 wt. % in H2O 526-95-4 1kg $36.1 2018-11-13 Buy
Sigma-Aldrich G1951 D-Gluconic acid solution 49-53 wt. % in H2O 526-95-4 4kg $93.6 2018-11-13 Buy
TCI Chemical G0036 Gluconic Acid (contains Gluconolactone)(45-50% in Water) 526-95-4 25g $14 2018-11-22 Buy
TCI Chemical G0036 Gluconic Acid (contains Gluconolactone)(45-50% in Water) 526-95-4 500g $23 2018-11-22 Buy
Alfa Aesar A16806 D-Gluconic acid, 50% aq. soln. 526-95-4 500ml $22.4 2018-11-13 Buy

Gluconic acid Chemical Properties,Uses,Production


Gluconic acid (also known as gluconate) is an organic compound occurring widely in nature arising from the glucose oxidation. It is naturally found in fruit, honey and wine. It can also be used as a food additive to regulate acidity and a cleaning agent in alkaline solution. Its calcium salt, calcium gluconate can be used to treat burns from hydrofluoric acid and avoid necrosis of deep tissues as well as treating the verapamil poisoning and hypocalcemia in hospitalized patient. Some salts of gluconate can also be used to treat malaria (quinidine gluconate) and anemia (ferrous gluconate). In microbiology, gluconate is a common carbon source that can be supplemented to the medium for cell growth.


[1]Mandelstam, J. "The repression of constitutive β-galactosidase in Escherichia coli by glucose and other carbon sources." Biochemical Journal82.3 (1962): 489.
[2]Ghotbi, Mohammad Yeganeh, et al. "LDH-intercalated d-gluconate: Generation of a new food additive-inorganic nanohybrid compound." Journal of Physics and Chemistry of Solids 70.6 (2009): 948-954.
[3]Perkins, C. M. "Serious verapamil poisoning: treatment with intravenous calcium gluconate." British medical journal 2.6145 (1978): 1127.
[4]Broner, Cynthia W., et al. "A prospective, randomized, double-blind comparison of calcium chloride and calcium gluconate therapies for hypocalcemia in critically ill children." The Journal of pediatrics 117.6 (1990): 986-989.
[5]Miller, K. D., A. E. Greenberg, and C. C. Campbell. "Treatment of severe malaria in the United States with a continuous infusion of quinidine gluconate and exchange transfusion. " New England Journal of Medicine321.2(1989):65-70.
[6]Gillespie RS(Driscoll Children's Hospital, Corpus Christi, TX 78411, USA., and J. M. Symons. "Sodium ferric gluconate for post-transplant anemia in pediatric and young adult renal transplant recipients." Pediatric Transplantation 9.1(2005):43–46.


Gluconic acid is an organic compound with molecular formula C6H12O7 and condensed structural formula HOCH2(CHOH)4COOH. It is one of the 16 stereoisomers of 2,3,4,5,6-penta hydroxy hexanoic acid.
In aqueous solution at neutral pH, gluconic acid forms the gluconate ion. The salts of gluconic acid are known as "gluconates". Gluconic acid, gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose. Some drugs are injected in the form of gluconates.

Chemical Properties

clear yellow to brownish-yellow solution

Physical properties

The chemical structure of gluconic acid consists of a six-carbon chain with five hydroxyl groups terminating in a carboxylic acid group. In aqueous solution, gluconic acid exists in equilibrium with the cyclic ester glucono delta-lactone.


Gluconic acid occurs naturally in fruit, honey, kombucha tea, and wine. As a food additive ( E574 ), it is an acidity regulator. It is also used in cleaning products where it dissolves mineral deposits especially in alkaline solution. The gluconate anion chelates Ca2+,Fe2+, Al3+, and other metals. In 1929 Horace Terhune Herrick developed a process for producing the salt by fermentation.
Calcium gluconate, in the form of a gel, is used to treat burns from hydrofluoric acid; calcium gluconate injections may be used for more severe cases to avoid necrosis of deep tissues. Quinine gluconate is a salt between gluconic acid and quinine, which is used for intramuscular injection in the treatment of malaria. Zinc gluconate injections are used to neuter male dogs. Iron gluconate injections have been proposed in the past to treat anemia.


A chemical used in glycolytic pathway studies.


Gluconic Acid is an acidulant that is a mild organic acid which is the hydrolyzed form of glucono-delta-lactone. it is prepared by the fermentation of dextrose, whereby the physiological d-form is produced. it is soluble in water with a solubility of 100 g/100 ml at 20°c. it has a mild taste and at 1% has a ph of 2.8. it functions as an antioxidant and enhances the function of other antioxidants. in beverages, syrups, and wine, it can eliminate calcium turbidities. it is used as a leavening component in cake mixes, and as an acid component in dry-mix desserts and dry beverage mixes.


A soluble crystalline organic acid made by the oxidation of glucose (using specific molds). It is used in paint strippers.


gluconic acid: An opticallyactive hydroxycarboxylic acid,CH2(OH)(CHOH)4COOH. It is the carboxylicacid corresponding to the aldosesugar glucose, and can be madeby the action of certain moulds.

brand name

Calglucon (Novartis).

Biotechnological Production

Currently, gluconic acid is commercially produced by submerged fed-batch cultivations of Aspergillus niger using glucose as substrate. A. niger produces citric acid and gluconic acid growing on glucose. The product concentration and yields of the product depend on the fermentation conditions. For optimal gluconic acid production, high glucose concentrations (110–250 g.L-1), low concentrations of nitrogen and phosphorus in the medium, a limitation of metal ion concentrations, a pH value in the range of 4.5–6.5, and high aeration rates for the oxygen supply are needed.
Much research has been carried out to find new ways for cheaper production. Different microorganisms have been studied (e.g. G. oxydans, Z. mobilis, A. methanolicous, and P. fluorescence. Moreover, new microbial strains have been developed by mutagenesis or genetic engineering. Additionally, the fermentation process and recovery have been optimized. New inexpensive substrates (e.g. cornstarch, grape or banana must, figs, and cheese whey) have been tested.
One example of a new and efficient production process of gluconic acid is the cultivation of Aureobasidium pullulans growing on glucose. Using a continuous process with biomass retention by crossover filtration, a product concentration of 375 g.L-1, a yield of 0.83 g of gluconic acid per gram of glucose, and a productivity of 17 g.L-1.h-1 could be achieved at a residence time of 22 h. In this process, 100 % of the glucose is converted. This process might be interesting for industrial applications. In continuous gluconic acid production with immobilized mycelia of A. niger, product concentrations of 120–140 g.L-1 have been achieved.

Gluconic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Gluconic acid Suppliers

Global( 175)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20095 58
hdzhl biotechnology co., ltd
86-13032617415 CHINA 500 58
career henan chemical co
+86-371-86658258 CHINA 20104 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40277 62

View Lastest Price from Gluconic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Gluconic acid
US $1.00 / kg 1kg 95%-99% as request career henan chemical co

Gluconic acid Spectrum

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