ChemicalBook >> CAS DataBase List >>MY-5445
MY-5445
- CAS No.
- 78351-75-4
- Chemical Name:
- MY-5445
- Synonyms
- MY-5445;MY 5445;MY5445;1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE;1-(3-Chloroanilino)-4-phenylphthalazine >1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE;N-(3-chlorophenyl)-4-phenylphthalazin-1-amine;N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine;1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-;aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
- CBNumber:
- CB9739543
- Molecular Formula:
- C20H14ClN3
- Molecular Weight:
- 331.8
- MDL Number:
- MFCD00209838
- MOL File:
- 78351-75-4.mol
- MSDS File:
- SDS
Last updated:2023-07-12 16:43:44
| Boiling point | 539.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.310±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml |
| pka | 4.91±0.30(Predicted) |
| form | Yellow solid. |
| color | White to Light yellow |
| FDA UNII | F8CSS73B6A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| NFPA 704 |
|
MY-5445 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2884 | 1-(3-Chloroanilino)-4-phenylphthalazine >98.0%(GC) | 78351-75-4 | 20mg | $105 | 2024-03-01 | Buy |
| TCI Chemical | C2884 | 1-(3-Chloroanilino)-4-phenylphthalazine >98.0%(GC) | 78351-75-4 | 100mg | $358 | 2024-03-01 | Buy |
| Cayman Chemical | 20872 | MY-5445 ≥98% | 78351-75-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20872 | MY-5445 ≥98% | 78351-75-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 20872 | MY-5445 ≥98% | 78351-75-4 | 10mg | $153 | 2024-03-01 | Buy |
MY-5445 Chemical Properties,Uses,Production
Description
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM.
Uses
MY-5445 is a selective cGMP phosphodiesterase inhibitor. Potent PDE5 inhibitor.
Definition
ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines.
Biological Activity
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M).
MY-5445 Preparation Products And Raw materials
Raw materials
Preparation Products
MY-5445 Suppliers
Global( 86)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | sales@zhiwe.net | China | 587 | 61 |
78351-75-4(MY-5445)Related Search:
MY-5445
1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE
1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
MY 5445;MY5445
1-(3-Chloroanilino)-4-phenylphthalazine >
aggregation,platelet,Inhibitor,anticancer,inhibit,MY5445,neuropathic,MY 5445,Phosphodiesterase (PDE),neuropathic pain,allodynia,MY-5445
1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-
78351-75-4
C20H14ClN3
Cyclic Nucleotide related