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Acetylcholine chloride

Acetylcholine chloride
Acetylcholine chloride structure
CAS No.
60-31-1
Chemical Name:
Acetylcholine chloride
Synonyms
ACH;ovisot;tl1505;miochol;acecholin;ACECOLINE;achchloride;arterocoline;ARTEROCHOLINE;Acetylcholine chlori
CBNumber:
CB9216208
Molecular Formula:
C7H16ClNO2
Formula Weight:
181.66
MOL File:
60-31-1.mol

Acetylcholine chloride Properties

Melting point:
146-150 °C (lit.)
Density 
1.1235 (rough estimate)
refractive index 
1.5560 (estimate)
storage temp. 
room temp
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White
Water Solubility 
Soluble IN COLD WATER
Sensitive 
Hygroscopic
Merck 
14,87
BRN 
3571875
Stability:
Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.
CAS DataBase Reference
60-31-1(CAS DataBase Reference)
FDA UNII
AF73293C2R
EPA Substance Registry System
Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (60-31-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H303-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36
WGK Germany  2
RTECS  FZ9800000
3-8-10-21
TSCA  Yes
HazardClass  IRRITANT
HS Code  29379000
Toxicity LD50 in mice, rats (mg/kg): 20, 22 i.v., 170, 250 s.c., 3000, 2500 i.p. (Molitor)
NFPA 704
0
1 0

Acetylcholine chloride price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A2661 Acetylcholine chloride suitable for cell culture 60-31-1 25g $64.1 2021-03-22 Buy
Sigma-Aldrich Y0000002 Acetylcholine chloride European Pharmacopoeia (EP) Reference Standard 60-31-1 $190 2021-03-22 Buy
Sigma-Aldrich A9101 Acetylcholine chloride pkg of 150?mg (per vial) 60-31-1 10 vials $256 2021-03-22 Buy
Sigma-Aldrich 1008501 Acetylcholine chloride United States Pharmacopeia (USP) Reference Standard 60-31-1 200mg $366 2021-03-22 Buy
TCI Chemical A0084 Acetylcholine Chloride >98.0%(T) 60-31-1 25g $42 2021-03-22 Buy

Acetylcholine chloride Chemical Properties,Uses,Production

Chemical Properties

White or almost white crystalline powder or colourless crystals, very hygroscopic.

Uses

Acetylcholine Chloride is a cholinergic.

Uses

cholinergic, antiarrhythmic, miotic, vasodilator (peripheral)

Uses

endogenous neurotransmitter at cholinergic synapses; amplifies sarcolemma action potential inducing muscle contractions

Uses

A cholinergic neurotransmitter that can induce the opening of calcium channels

Definition

ChEBI: The chloride salt of acetylcholine, and a parasympatomimetic drug.

brand name

Miochol (Novartis).

General Description

ACh chloride exerts a powerfulstimulant effect on the parasympathetic nervous system.Attempts have been made to use it as a cholinergic agent,but its duration of action is too short for sustained effects,because of rapid hydrolysis by esterases and lack of specificitywhen administered for systemic effects. It is a cardiacdepressant and an effective vasodilator. Stimulation of thevagus and the parasympathetic nervous system produces atonic action on smooth muscle and induces a flow from thesalivary and lacrimal glands. Its cardiac-depressant effectresults from (a) a negative chronotropic effect that causes adecrease in heart rate and (b) a negative inotropic action onheart muscle that produces a decrease in the force of myocardialcontractions.

Biological Activity

Endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

Clinical Use

Atropine blocks the depressant effect of ACh on cardiacmuscle and its production of peripheral vasodilation (i.e.,muscarinic effects) but does not affect the skeletal musclecontraction (i.e., nicotinic effect) produced.ACh chloride is a hygroscopic powder that is available inan admixture with mannitol to be dissolved in sterile waterfor injection shortly before use. It is a short-acting mioticwhen introduced into the anterior chamber of the eye and isespecially useful after cataract surgery during the placementof sutures. When applied topically to the eye, it has littletherapeutic value because of poor corneal penetration andrapid hydrolysis by AChE.

Safety Profile

Poison by subcutaneous, intravenous, and parenteral routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. A cholinergic agent. See also CHOLINE ACETATE (ESTER).

Purification Methods

It is very soluble in H2O (>10%), and is very hygroscopic. If pasty, dry it in a vacuum desiccator over H2SO4 until a solid residue is obtained. Dissolve this in absolute EtOH, filter it and add dry Et2O, when the hydrochloride separates. Collect by filtration and store it under very dry conditions. [Jones & Major J Am Chem Soc 52 307 1930.] The chloroplatinate crystallises from hot H2O in yellow needles and can be recrystallised from 50% EtOH, m 242-244o [Dudley Biochem J 23 1069 1929]; other m given is 256-257o. The perchlorate crystallises from EtOH as prisms m 116-117o. [J Am Pharm Assocn 36 272 1947, Beilstein 4 IV 1446.]

Acetylcholine chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Acetylcholine chloride Suppliers

Global( 243)Suppliers
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View Lastest Price from Acetylcholine chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Acetylcholine chloride
60-31-1
US $1.00-500.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-09-07 Acetylcholine chloride
60-31-1
US $10.00 / KG/Tin 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-07-28 Acetylcholine chloride USP/EP/BP
60-31-1
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

Acetylcholine chloride Spectrum


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