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セフィキシム

セフィキシム 化学構造式
79350-37-1
CAS番号.
79350-37-1
化学名:
セフィキシム
别名:
(6R,6β)-7α-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;(6R,7R)-7-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;セフィーナ;セフィキシム;セキシム;セフスパン;抗生物質FK-027;セフパ;(6R)-7α-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;セフィラート;(6R,7R)-7-[[(Z)-(2-アミノ-4-チアゾリル)[(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;セキスパノン;セフィキシム (JAN)
英語化学名:
Cefixime
英語别名:
CFIX;fk027;Suprax;Oroken;Saprax;fr17027;Cefspan;Unixime;Cefixim;cl284635
CBNumber:
CB4210362
化学式:
C16H15N5O7S2
分子量:
453.45
MOL File:
79350-37-1.mol

セフィキシム 物理性質

融点 :
218-225°C
貯蔵温度 :
Hygroscopic, Refrigerator, Under Inert Atmosphere
溶解性:
Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate.
酸解離定数(Pka):
pKa 2.10 (Uncertain)
水溶解度 :
55.11 mg/L
CAS データベース:
79350-37-1(CAS DataBase Reference)

安全性情報

主な危険性  Xn
Rフレーズ  42/43
Sフレーズ  22-36/37-45
WGK Germany  3
10-23
HSコード  38210000

セフィキシム 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCC242800 セフィキシム
Cefixime
79350-37-1 1mg ¥11300 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCC242800 セフィキシム
Cefixime
79350-37-1 5mg ¥18800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCC242800 セフィキシム
Cefixime
79350-37-1 10mg ¥25000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCC242800 セフィキシム
Cefixime
79350-37-1 100mg ¥35000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCC242800 セフィキシム
Cefixime
79350-37-1 500mg ¥43800 2018-12-26 購入

セフィキシム 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

説明

Cefixime is the first orally active third-generation cephalosponn with a true broad spectrum of activity. It is reportedly more effective against Gram-negative bacteria than conventional oral cephems such as cephalexin and cefaclor.

化学的特性

Cefixime is an oral third generation cephalosporin antibiotic. It was sold under the trade name Suprax in the United States until 2003. The oral suspension form of “Suprax” was re-launched. Cefixime is prescribed for bacterial infections of the chest, ears, urinary tract, and throat (tonsilitis and pharyngitis), and for uncomplicated gonorrhea, upper and lower respiratory tract infections, acute otitis media, and gonococcal urethritis.

化学的特性

Pale Yellow Solid

Originator

Fujisawa (Japan)

使用

Cephalosporin antibacterial

使用

Orally active, third generation cephalosporin antibiotic

定義

ChEBI: A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea tonsilitis, pharyngitis, bronchitis, and urinary tract infections.

brand name

Suprax(Lupin);Cefspan.

抗菌性

It is active against N. gonorrhoeae, M. catarrhalis, H. influenzae and a wide range of enterobacteria, including most strains of Citrobacter, Enterobacter and Serratia spp. Its antistaphylococcal activity is poor. It is not active against Acinetobacter spp., Ps. aeruginosa or B. fragilis. It is resistant to hydrolysis by common β-lactamases.

健康ハザード

Exposures to cefi xime may cause side effects that include, but are not limited to, stomach and abdominal pain, diarrhea, vomiting, mild skin rash, headache, fever, urticaria, pruritis, eosinophilia, leucopenia, anaphylaxis, superinfection, hemolytic anemia, dyspepsia, and fl atulence. Also, cefi xime may cause transient elevation of SGOT, SGPT, alkaline phosphatase, BUN, and creatinine. Reports have indicated that cefi xime is mainly excreted unchanged in the bile and urine

薬物動態学

Oral absorption: c. 50%
Cmax 400 mg oral: 4–5.5 mg/L after 4 h
Plasma half-life: 3-ndash;4 h
Volume of distribution: 0.1 L/kg
Plasma protein binding: 60-ndash;70%
Absorption and distribution
Oral absorption is slow and incomplete, but is unaffected by aluminum magnesium hydroxide. Penetration into cantharides blister fluid was very slow but exceeded the plasma level. CSF concentrations are poor even in the presence of meningeal inflammation, reaching an average of around 0.22 mg/L in children with meningitis.
Metabolism and excretion
It is not metabolized and is excreted unchanged in urine (mainly by glomerular filtration) and in bile, in which concentrations exceeding 100 mg/L have been found. Less than 20% of an oral dose is recovered from the urine over 24 h, falling to less than 5% in patients with severe renal impairment, with a corresponding increase in plasma concentration. It is not removed by peritoneal or hemodialysis.

臨床応用

Cefixime (Suprax) is the first orally active, third-generationcephalosporin that is not an ester prodrug to be approved fortherapy in the United States. Oral bioavailability is surprisinglyhigh, ranging from 40% to 50%. Facilitated transportof cefixime across intestinal brush border membranes involvingthe carrier system for dipeptides may explain itssurprisingly good oral absorption. This result was not expectedbecause cefixime lacks the ionizable α-amino grouppresent in dipeptides and β-lactams previously known to betransported by the carrier system.Cefixime is a broad-spectrum cephalosporin that is resistantto many β-lactamases. It is particularly effective againstGram-negative bacilli, including E. coli, Klebsiella spp., P.mirabilis, indole-positive Proteus, Providencia, and someCitrobacter spp. Most Pseudomonas, Enterobacter, andBacteroides spp. are resistant. It also has useful activityagainst streptococci, gonococci, H. influenzae, and M. catarrhalis.It is much less active against S. aureus. Cefixime isused for the treatment of various respiratory tract infections(e.g., acute bronchitis, pharyngitis, and tonsillitis) and otitismedia. It is also used to treat uncomplicated urinary tract infectionsand gonorrhea caused by β-lactamase–producingbacterial strains.
The comparatively long half-life of cefixime (t1/2 is3–4 hours) allows it to be administered on a twice-a-dayschedule. Renal tubular reabsorption and a relatively high fraction of plasma protein binding (~65%) contribute to thelong half-life. It is provided in two-oral dosage forms: 200-or 400-mg tablets and a powder for the preparation of anaqueous suspension.

臨床応用

Cefixime has been used successfully in uncomplicated cystitis, upper and lower respiratory tract infections and various other infections. Its failure to provide adequate cover for staphylococci should be noted.

副作用

It is well tolerated, but diarrhea is fairly common and pseudomembranous colitis has been reported. Other side effects common to cephalosporins are occasionally seen.

予防処置

Users of cefi xime should be careful in health conditions such as neonates, pregnancy, lactation, and renal failure. Users should follow suitable and appropriate health care measures to control superinfection (if it happens during therapy). It is contraindicated in patients with a known allergy to penicillin or any other ingredients of Taximax. Taxim-O is contraindicated in patients with a known allergy to the cephalosporin group of antibiotics.

セフィキシム 上流と下流の製品情報

原材料

準備製品


セフィキシム 生産企業

Global( 221)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8416 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19947 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32606 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19975 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Wuhan Wsem Biological Co., Ltd. 027-59402396 ; 13419635609(WX)
027-59402396 13419635609@163.com China 4581 55
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD 18028682016 13682223272 18922377114 18922377004
020-87659730 dylan@gzbr.com.cn China 199 58

79350-37-1(セフィキシム)キーワード:


  • 79350-37-1
  • YTTERBIUM(III) IONOPHORE I
  • )(carboxymethoxy)imino)acetylamino)-3-ethenyl-8-oxo-,(6r-(6-alpha,7-beta(z)))
  • cl284635
  • fk027
  • fr17027
  • 8-[[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
  • (6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)GLOXYLAMIDO]-8-OXO-3-VINYL-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 72-(Z)-[O-(CARBOXYMETHYL)OXIME]TRIHYDRATE
  • CEFIXME TRIHYDRATE
  • CEFIXIME
  • CEFIXIME TRIHYDRATE
  • Suprax
  • CEFIXIME MICRONIZED
  • CEFIXIME CEPHALOSPORINS
  • Cefixime (comp)
  • (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • Cefixoral
  • Cefspan
  • Cephoral
  • Unixime
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)- (9CI)
  • Oroken
  • CEFIXIME(7-[[(2-AMINO-4-THIAZOLGL)(CARBOXYMETHOXG)IMINO]ACETYL]AMINO-3-VINYL-8-OXO-5-THIA-1-AZABICYCLO[4,2,0]OCT-2-ENE-2-CARBOXYLICACIDTRIHYDRATE)
  • [6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Ceftmral
  • CFIX
  • Saprax
  • Supracef
  • (6R,6β)-7α-[[(2-Amino-4-thiazolyl)[(Z)-(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Antibiotic FK-027
  • (6R,6β)-7α-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • (6R,7R)-7-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セフィーナ
  • セフィキシム
  • セキシム
  • セフスパン
  • 抗生物質FK-027
  • セフパ
  • (6R)-7α-[[(2-アミノ-4-チアゾリル)[(Z)-(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セフィラート
  • (6R,7R)-7-[[(Z)-(2-アミノ-4-チアゾリル)[(カルボキシメトキシ)イミノ]アセチル]アミノ]-3-エテニル-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セキスパノン
  • セフィキシム (JAN)
  • セファロスポリン類
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