ChemicalBook
Chinese english Germany Korea

DL-リンゴ酸

DL-リンゴ酸 化学構造式
6915-15-7
CAS番号.
6915-15-7
化学名:
DL-リンゴ酸
别名:
DL-リンゴ酸;DLリンゴ酸;1-ヒドロキシエタン-1,2-ジカルボン酸;2-ヒドロキシブタン二酸;リンゴ酸;DL‐りんご酸;DL‐リンゴ酸標準品
英語化学名:
Malic acid
英語别名:
E 296;malic;DL-Malic;FDA 2018;NSC 25941;DL-MALATE;MALIC ACID;Nanoveson M;pomalusacid;Pomalus acid
CBNumber:
CB7220795
化学式:
C4H6O5
分子量:
134.09
MOL File:
6915-15-7.mol

DL-リンゴ酸 物理性質

融点 :
131-133 °C(lit.)
沸点 :
167.16°C (rough estimate)
比旋光度 :
[α]D20 -0.5~+0.5° (c=5, H2O)
比重(密度) :
1.609
蒸気密度:
4.6 (vs air)
蒸気圧:
<0.1 mm Hg ( 20 °C)
屈折率 :
1.3920 (estimate)
闪点 :
203 °C
貯蔵温度 :
2-8°C
溶解性:
methanol: 0.1 g/mL, clear, colorless
酸解離定数(Pka):
3.4(at 25℃)
外見 :
neat
PH:
2.3 (10g/l, H2O, 20℃)
光学活性 (optical activity):
[α]/D 0.10 to +0.10°
水溶解度 :
558 g/L (20 ºC)
Merck :
14,5707
BRN :
1723539
CAS データベース:
6915-15-7(CAS DataBase Reference)
NISTの化学物質情報:
Hydroxybutanedioic acid(6915-15-7)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  22-37/38-41-36/37/38-42/43-34
Sフレーズ  26-39-37/39-36-36/39
WGK Germany  1
RTECS 番号 ON7175000
自然発火温度 644 °F
TSCA  Yes
HSコード  29181980
有毒物質データの 6915-15-7(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 3200 mg/kg
化審法 (2)-1442 届出不要化学物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。
P405 施錠して保管すること。

DL-リンゴ酸 価格 もっと(39)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-9433 Dl-りんご酸
Dl-malic acid
6915-15-7 25g ¥5400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-9433 Dl-りんご酸
Dl-malic acid
6915-15-7 5g ¥3600 2018-12-26 購入
東京化成工業 M0020 DL-りんご酸 >99.0%(T)
DL-Malic Acid >99.0%(T)
6915-15-7 500g ¥1800 2018-12-04 購入
東京化成工業 M0020 DL-りんご酸 >99.0%(T)
DL-Malic Acid >99.0%(T)
6915-15-7 25g ¥1600 2018-12-04 購入
関東化学株式会社(KANTO) 25044-00 DL‐りんご酸 >99.0%(T)
DL‐Malic acid >99.0%(T)
6915-15-7 500g ¥2200 2018-12-13 購入

DL-リンゴ酸 MSDS


DL-Hydroxybutanedioic acid

DL-リンゴ酸 化学特性,用途語,生産方法

外観

白色の結晶又は結晶性の粉末

定義

本品は、次の化学式で表される有機酸である。

溶解性

水、エタノール及びアセトンに溶けやすく、ジエチルエーテルに溶けにくい。

用途

酸味剤、医薬品原料、乳化安定剤。

用途

食品の酸味料、呈味改良剤

用途

酸の1次標準物質としてアルカリ標準液の標定に用いる(当量67.045)。

化粧品の成分用途

pH調整剤、香料

化学的特性

White or nearly white, crystalline powder or granules having a slight odor and a strongly acidic taste. It is hygroscopic. The synthetic material produced commercially in Europe and the USA is a racemic mixture, whereas the naturally occurring material found in apples and many other fruits and plants is levorotatory.

化学的特性

White to nearly white crystals or crystal powder

使用

Malic acid, HOOCCH(OH).CH2COOH, also known as hydroxysuccinic acid, is a colorless solid. It is soluble in water and alcohol. Malic acid exists in two optically active forms and a racemic mixture. It is used in medicine and found in apples and other fruits.
The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece

使用

malic acid is the third smallest alpha hydroxy acid in terms of molecular size. Although it is used in numerous cosmetic products, particularly those indicating a “fruit acid” content and generally designed for anti-aging, unlike glycolic and lactic acids, its skin benefits have not been extensively studied. Some formulators consider it difficult to work with, particularly when compared to other AHAs, and it can be somewhat irritating. It is rarely used as the only AHA in a product. It is found naturally occurring in apples.

使用

Malic Acid is an acidulant that is the predominant acid in apples. it exists as white crystalline powder or granules and is considered hygroscopic. as compared to citric acid, it is slightly less soluble but is still readily soluble in water with a solubility of 132 g/100 ml at 20°c. it has a stronger apparent acid taste and has a longer taste retention than citric acid which peaks faster but does not mask the aftertaste as effectively. a quantity of 0.362–0.408 kg of malic acid is equivalent to 0.453 kg of citric acid and to 0.272–0.317 kg of fumaric acid in tartness. at temperatures above 150°c it begins to lose water very slowly to yield fumaric acid. it is used in soft drinks, dry-mix beverages, puddings, jellies, and fruit filling. it is used in hard can- dies because it has a lower melting point (129°c) than citric acid which improves the ease of incorporation.

調製方法

Malic acid is manufactured by hydrating maleic and fumaric acids in the presence of suitable catalysts. The malic acid formed is then separated from the equilibrium product mixture.

定義

ChEBI: A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.

定義

A colorless crystalline carboxylic acid that is found in unripe fruits. It tastes of apples and is used in food flavorings.

Biotechnological Production

DL-malic acid as well as L-malic acid can be used in beverage, food, and animal nutrition. DL-malic acid is mainly derived from chemical synthesis, whereas L-malic acid is produced biotechnologically by enzymatic or fermentative processes.
Fumaric acid can be converted to L-malic acid using fumarases. Different microorganisms (e.g. Brevibacterium flavum, Brevibacterum ammoniagenes, and Corynebacterium species) are able to form naturally high amounts of fumarase intracellularly. For example, B. flavum has been immobilized in j-carrageenan and polyethyleneimine for whole-cell biocatalysis. A fumarase activity of 2.16 mmol.ml(gel)-1.h -1 at 55 C has been reported. This process has been used to produce 30 metric tons of L-malic acid per month in a continuous process with a 1,000 L column fed at a flow rate of 450 L.h-1 of 1 M sodium fumarate solution. Genetic engineering has been used to improve productivity, by which S. cerevisiae is modified to overexpress fumarase. With this method, a conversion rate of 65 mmol.g-1.h -1 has been observed.
Another possibility is the cultivation of an L-malic acid forming microorganism (e.g. Aspergillus flavus or Schizophyllum commune). The best results have been achieved by cultivation of A. flavus on glucose.Afinal product concentration of 113 g.L-1 with a yield of 1.26 mol of malic acid per mole of glucose and a productivity of 0.59 g.L-1.h-1 has been measured. Moreover, new biotechnological routes have been described using metabolically engineered S. cereviciae. In batch cultivations, concentrations up to 59 g.L-1 with a yield of 0.42 mol of malic acid per mole of glucose and a productivity of 0.19 g.L-1.h-1 have been observed.

応用例(製薬)

Malic acid is used in pharmaceutical formulations as a generalpurpose acidulant. It possesses a slight apple flavor and is used as a flavoring agent to mask bitter tastes and provide tartness. Malic acid is also used as an alternative to citric acid in effervescent powders, mouthwashes, and tooth-cleaning tablets.
In addition, malic acid has chelating and antioxidant properties. It may be used with butylated hydroxytoluene as a synergist in order to retard oxidation in vegetable oils. In food products it may be used in concentrations up to 420 ppm.
Therapeutically, malic acid has been used topically in combination with benzoic acid and salicylic acid to treat burns, ulcers, and wounds. It has also been used orally and parenterally, either intravenously or intramuscularly, in the treatment of liver disorders, and as a sialagogue.

安全性プロファイル

A poison by intraperitoneal route. Moderately toxic by ingestion. A skin and severe eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Malic acid is used in oral, topical, and parenteral pharmaceutical formulations in addition to food products, and is generally regarded as a relatively nontoxic and nonirritant material. However, concentrated solutions may be irritant.
LD50 (rat, oral): 1.6 g/kg(3)
LD50 (rat, IP): 0.1 g/kg

貯蔵

Malic acid is stable at temperatures up to 150°C. At temperatures above 150°C it begins to lose water very slowly to yield fumaric acid; complete decomposition occurs at about 180°C to give fumaric acid and maleic anhydride.
Malic acid is readily degraded by many aerobic and anaerobic microorganisms. Conditions of high humidity and elevated temperatures should be avoided to prevent caking.
The effects of grinding and humidity on malic acid have also been investigated.
The bulk material should be stored in a well-closed container, in a cool, dry place.

純化方法

Crystallise the acid from acetone, then from acetone/CCl4, or from ethyl acetate by adding pet ether (b 60-70o). Dry it at 35o under 1mm pressure to avoid formation of the anhydride. [Beilstein 3 IV 1124.]

不和合性

Malic acid can react with oxidizing materials. Aqueous solutions are mildly corrosive to carbon steels.

規制状況(Regulatory Status)

GRAS listed. Both the racemic mixture and the levorotatory isomer are accepted as food additives in Europe. The DL and L forms are included in the FDA Inactive Ingredients Database (oral preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

DL-リンゴ酸 上流と下流の製品情報

原材料

準備製品


DL-リンゴ酸 生産企業

Global( 321)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58

6915-15-7(DL-リンゴ酸)キーワード:


  • 6915-15-7
  • High quality organic DL-Malic acid 6915-15-7 kf-wang(at)kf-chem.com
  • DL-HYDROXYSUCOINIC ACID
  • DL-HYROXYBUTANEDIOIC ACID
  • (+/-)-MALIC ACID
  • MALIC ACID
  • MALIC ACID, DL-
  • DL-MALIC ACID FREE ACID
  • DL-MALIC ACID 99+% FCC
  • MALIC ACID, USP
  • DL(+-)-MALIC ACID EXTRA PURE, FCC
  • DL-MALIC ACID, 99+%
  • DL-Malic
  • 2-hydroxybutanedioic acid
  • MALICACIDANDITSCOMMONSALTS
  • alpha-Hydroxysuccinic acid
  • alpha-hydroxysuccinicacid
  • (±)-2-Hydroxysuccinic acid, DL-Hydroxybutanedioic acid, DL-Malic acid
  • (±)-2-Hydroxysuccinic acid, DL-Hydroxybutanedioic acid
  • 1-Hydroxyethane-1,2-dicarboxylic acid
  • MALIC ACID, DL-(P)
  • DL-Malic acid, extra pure, NF, FCC, E 296
  • DL-Malic acid,(±)-2-Hydroxysuccinic acid, DL-Hydroxybutanedioic acid
  • Malic Acid (500 mg)
  • DL-Malic acid, 99+% 500GR
  • E 296
  • FDA 2018
  • Nanoveson M
  • NSC 25941
  • DL-MALIC ACID FOR SYNTHESIS 1 KG
  • DL-MALIC ACID FOR SYNTHESIS 5 KG
  • DL-リンゴ酸
  • DLリンゴ酸
  • 1-ヒドロキシエタン-1,2-ジカルボン酸
  • 2-ヒドロキシブタン二酸
  • リンゴ酸
  • DL‐りんご酸
  • DL‐リンゴ酸標準品
Copyright 2017 © ChemicalBook. All rights reserved