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perhexiline

perhexiline 구조식 이미지

카스 번호:: 6621-47-2

상품명:: perhexiline

동의어(영문):: perhexilene;perhexiline;Perhexilline;Perhexiline USP/EP/BP;Perhexiline (Mixture of Diastereomers);(S)-2-(2,2-Dicyclohexylethyl)piperidine;(R)-2-(2,2-Dicyclohexylethyl)piperidine;(2S)-2-(2,2-Dicyclohexylethyl)piperidine;(2R)-2-(2,2-Dicyclohexylethyl)piperidine

CBNumber:: CB0875583

분자식:: C19H35N

포뮬러 무게:: 277.49

MOL 파일:: 6621-47-2.mol

속성

안전

용도

공급 업체 29

perhexiline 속성

끓는 점: 340.0±10.0 °C(Predicted)

밀도: 0.926±0.06 g/cm3(Predicted)

산도 계수 (pKa): pKa 10.36 ± 0.06(40% EtOH,t =25,) (Uncertain)

안전

perhexiline C화학적 특성, 용도, 생산

용도

Vasodilator (coronary).

효소 저해제

This calcium-blocking vasodilator (FW = 277.49 g/mol; CAS 6621-47-2; typically supplied as the maleate or HCl salt), also known as Pexid? and 2- (2,2-dicyclohexylethyl)piperidine, is used to treat angina. It does so by targetting carnitine palmitoyltransferase-1 (CPT-1), an enzyme that controls the access of long chain fatty acids to the mitochondrial site of b-oxidation, showing concentration-dependent inhibition in vitro, using rat cardiac mitochondria, IC50 = 77 μM, and hepatic mitochondria, IC50 = 148 μM. Amiodarone, another drug with anti-anginal properties, likewise inhibits cardiac CPT-1 (IC50 = 228 μM). The rank order of potency for inhibition was malonyl-CoA > 4-hydroxyphenylglyoxylate = perhexiline > amiodarone = monohydroxy-perhexiline. Inhibition was competitive with respect to palmitoyl-CoA but non-competitive inhibition with respect to carnitine. This shifts myocardial metabolism from fatty acid to glucose utilisation which results in increased ATP production for the same O2 consumption and consequently increases myocardial efficiency. (See also Meldonium) Other Target(s): CYP2D6; glutathione S-transferase; Mg2+-ATPase; NADH dehydrogenase; Na+ /K+ -exchanging ATPase; b-oxidation; oxidative phosphorylation; and succinate dehydrogenase.

perhexiline 준비 용품 및 원자재

원자재

염산 수산화나트륨 수소 CYCLOHEXYLMAGNESIUM BROMIDE 포름산에틸 말레인산

준비 용품

perhexiline 공급 업체

글로벌( 29)공급 업체

공급자	전화	이메일	국가	제품 수	이점
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9271	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29118	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Chongqing Chemieliva Pharmaceutical Co., Ltd.	023-67770219	jessica.hu@chemieliva.com	China	1423	60

perhexiline 관련 검색:

1,4-다이아자사이클로헥세인 소듐 하이드라이드 황산 아연 Adapalene cis-Hydroxy Perhexiline(Mixture of Diastereomers) trans-Hydroxy Perhexiline-d11(Mixture of Diastereomers) Hydroxy Perhexiline-d11(Mixture of Diastereomers) cis-Hydroxy Perhexiline-d11(Mixture of Diastereomers) trans-Hydroxy Perhexiline(Mixture of Diastereomers) Hydroxy Perhexiline (Mixture of Diastereomers) Perhexiline-d11(Mixture of Diastereomers) PERHEXILINE MALEATE SALT perhexiline