붕산트리메틸
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붕산트리메틸 속성
- 녹는점
- -34 °C (lit.)
- 끓는 점
- 68-69 °C (lit.)
- 밀도
- 0.932 g/mL at 20 °C (lit.)
- 증기 밀도
- 3.59 (vs air)
- 증기압
- 147.9-148 hPa ( 20 °C)
- 굴절률
- n
20/D 1.358(lit.)
- 인화점
- 8 °F
- 저장 조건
- Store at <= 20°C.
- 용해도
- 테트라히드로푸란, 에테르, 이소포르필아민, 헥산 및 메탄올과 혼합 가능.
- 물리적 상태
- 액체
- 색상
- 무색의
- Specific Gravity
- 0.915
- 수용성
- 물과 반응
- 감도
- Moisture Sensitive
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- Merck
- 14,9712
- BRN
- 1697939
- Dielectric constant
- 8.2(20℃)
- 노출 한도
- ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
- 안정성
- 안정적인. 산화제와 호환되지 않습니다. 수분이 있으면 천천히 분해되고 물에서는 빠르게 분해됩니다. 가연성.
- InChIKey
- WRECIMRULFAWHA-UHFFFAOYSA-N
- CAS 데이터베이스
- 121-43-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,F,T | ||
---|---|---|---|
위험 카페고리 넘버 | 11-21-23/25-36/37/38-10-36-61-60 | ||
안전지침서 | 16-27-36/37/39-45-25-23-2-26-53 | ||
유엔번호(UN No.) | UN 2416 3/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | ED5600000 | ||
F 고인화성물질 | 21 | ||
자연 발화 온도 | 305°C | ||
TSCA | Yes | ||
위험 등급 | 3 | ||
포장분류 | II | ||
HS 번호 | 29209085 | ||
유해 물질 데이터 | 121-43-7(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 6.14 ml/kg (Smyth) | ||
기존화학 물질 | KE-03514 |
붕산트리메틸 C화학적 특성, 용도, 생산
화학적 성질
Water-white moisture-sensitive liquid, fumes in the air. It forms an azeotrope with methanol with an azeotrope of 55°C. Miscible with ether, methanol, hexane, tetrahydrofuran; It is stable in anhydrous state and decomposes into methanol and boric acid in presence of water.
용도
Trimethyl borate is a useful reagent in organic synthesis. It is involved in the production of resins, waxes and paints and acts as a methylation agent. As a boron source, Trimethyl borate is used to prepare flame retardants, anti-oxidants and corrosion inhibitors. It reacts with Grignard reagents followed by hydrolysis to prepare boronic acid. It is also used as a precursor of borate esters, which finds application in the Suzuki coupling reaction. It is used as neutron detector gas in the presence of a scintillation counter; as a promoter of diborane reactions.제조 방법
The preparation method of trimethyl borate1. The direct reaction between boric acid and methanol is as follows:
3CH30H+H3B03→B (OCH3) 3+3H20
Usually the trimethyl borate formed in the reaction forms an azeotrope with excess methanol and is distilled out together, and then the trimethyl borate is obtained by separating the azeotrope.
2. The direct reaction between boron oxide and methanol is as follows:
B203+6CH30H→2B (OCH3) 3+3H20
3. Borax, methanol and sulfuric acid are directly reacted, and the reaction formula is :
Na2B4O7.1OH2O+12CH30H+2H2S04→4B (OCH3)3+2NaHS04+17H20
주요 응용
Trimethyl borate reacts with a Grignard reagent or organolithium compounds to yield dimethyl boronates, which upon subsequent aqueous acid treatment afford corresponding boronic acids. The resultant boronic acids or esters are useful intermediates in various cross-coupling reactions such as Suzuki coupling and Chan-Lam coupling. It is also used in the preparation of sodium borohydride.정의
ChEBI: Trimethyl borate is a member of the class of borate esters obtained by the formal condensation of three equivalents of methanol with boric acid.화학 반응
Trimethyl borate B(OCH3)3 is a popular borate ester used in organic synthesis.borate esters are prepared from alkylation of trimethyl borate:
ArMgBr + B(OCH3 )3 → MgBrOCH3 + ArB(OCH3 )2
ArB(OCH3 )2 + 2H2O → ArB(OH)2 + 2 HOCH3
일반 설명
Trimethyl borate appears as a water-white liquid. Denser than water. Vapors heavier than air. Used as a solvent and fungicide for fruit.공기와 물의 반응
Highly flammable. Rapidly decomposes in water.반응 프로필
Borates, such as Trimethyl borate, behave similarly to esters in that they react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters/borates with alkali metals and hydrides.건강위험
Trimethyl borate may cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.화재위험
HIGHLY FLAMMABLE: Trimethyl borate will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.Safety Profile
Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An eye irritant. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderately explosive when exposed to flame. Will react with water or steam to produce toxic and flammable vapors. To fight fire, use dry chemical, CO2, spray, foam. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and BORON COMPOUNDS.Purification Methods
Carefully fractionate the borate through a gauze-packed column. Re-distil and collect it in weighed glass vials and seal them. Keep it away from moisture. It undergoes alkyl exchange with alcohols and forms azeotropes, e.g. with MeOH the azeotrope consists of 70% (MeO)3B and 30% MeOH with b 52-54o/760mm, d 0.87. [Charnley et al. J Chem Soc 2288 1952, Gerrard & Lappert Chem Ind (London) 53 1952, Schlesinger et al. J Am Chem Soc 75 213 1953.] It has also been dried with Na and then distilled. [Beilstein 1 IV 1269.]붕산트리메틸 준비 용품 및 원자재
원자재
준비 용품
벤조푸란-2-보론산
8-Quinolineboronic acid
1-Methyl-4-pyrazole boronic acid pinacol ester
4-Isopropylbenzeneboronic acid
2-(Methanesulfonylamino)phenylboronic acid
Isopropenylboronic acid pinacol ester
2-(N,N-디에틸아미노카르보닐)페닐보론산
Biphenyl-3-boronic acid
2-FLUOROPHENYLBORONIC ACID
2-ISOPROPOXYPHENYLBORONIC ACID
2-나프탈렌붕산
1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER
Benzylboronic acid
4-tert-Butylphenylboronic acid
4-(메틸티오)페닐보론산
2,3-Dimethylphenylboronic acid
2,6-Difluorophenol
2,5-Dichlorophenylboronic acid
1,4-Phenylenebisboronic acid
3,5-Dimethylisoxazole-4-boronic acid
2-Fluorophenylboronic acid
3,4-메틸렌다이옥실페닐붕산
5-METHOXYBENZOFURAN-2-BORONIC ACID
4-Benzyloxybenzeneboronic acid
티아나프텐-2-붕소산
(4-PHENYLAMINOCARBONYLPHENYL)BORONIC ACID
테트라페닐붕산 나트륨
2,2'-BITHIOPHENE-5-BORONIC ACID
4-FLUORO-2-NITROPHENYLBORONIC ACID
2-Methoxypyridine-3-boronic acid
2-Benzyloxyphenylboronic acid
4-Cyanophenylboronic acid
3-Methoxymethylphenylboronic acid
3,4,5-트리플루오로페놀
4-FLUORO-3-(HYDROXYMETHYL)BENZENEBORONIC ACID
메틸4-보로노벤조에이트
4-PHENOXYPHENYLBORONIC ACID
5-Indolylboronic acid
1-메틸-1H-피라졸-5-보론산피나콜에스테르
Quinoline-5-boronic acid
붕산트리메틸 공급 업체
글로벌( 416)공급 업체
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Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5888 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20262 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
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Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 |
bj1@bj-chem.com | China | 299 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21632 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1803 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2986 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29871 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8497 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |