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키토산

키토산
키토산 구조식 이미지
카스 번호:
9012-76-4
한글명:
키토산
동의어(한글):
키토산
상품명:
Chitosan
동의어(영문):
cta4;dac70;chicol;kytexh;kytexm;flonacc;flonacn;CHITOSAN;ChMtosan;seacuref
CBNumber:
CB1479274
분자식:
C6H11NO4X2
포뮬러 무게:
161.16
MOL 파일:
9012-76-4.mol

키토산 속성

저장 조건
room temp
용해도
dilute aqueous acid (pH <6.5).: soluble
물리적 상태
(Coarse ground flakes and powder)
색상
White to Off-white
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
9012-76-4
EPA
Chitosan(9012-76-4)

안전

위험품 표기 Xn
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 24/25-36-26
WGK 독일 -
RTECS 번호 FM6300000
F 고인화성물질 3
TSCA Yes
HS 번호 39139000

키토산 MSDS


Chitosan

키토산 C화학적 특성, 용도, 생산

존재

게나 가재, 새우 등 갑각류가 가지고 있는 성분인 키틴을 인체 내에서 흡수하기 위해 탈아세틸화 시켜 얻어낸 물질로서 1811년 프랑스의 화학자 앙코 브라코노가 버섯에서 키틴을 발견한 것을 바탕으로 1859년 화학자 루게가 키틴을 틸아세틸화하여 만들어 냈고 1894년에 과학자 후페 자이라가 이 물질을 키토산이라 명명했다. 화학적으로 본다면, 포도당에서 수소 하나를 아민기로 대체한 것을 사슬 형태로 이어놓은 꼴이다.

개요

우선적으로 콜레스테롤에 관련해서 효과가 좋다. 체내에 과잉된 유해 콜레스테롤을 흡착, 배설하는 역할 즉 탈콜레스테롤 작용을 한다. 혈관 질환을 예방 및 개선하는데 큰 효과가 있다고 이미 식약청에서 인정된 바 있다. 또한 암 세포의 증식을 억제하는 항암 작용을 하는데 직접적인 암 세포 파괴가 아닌 면역력 강화와 비정상 세포에 흡착하여 암 세포의 증식과 성장을 방해하는 역할을 한다. 매우 좋다. 무튼 주 효능은 위에 서술된 세 가지가 제일 크고 이외에도 피부 및 모발에 좋으며 항균, 항바이러스 작용, 오염 물질 배출, 간 기능 개선, 혈당조절 등의 자잘한 효과도 가지고 있다고.

화학적 성질

faintly beige solid

화학적 성질

Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’.

용도

Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.

용도

Ideal for wound healing and hemostasis; biosurgery and ophthalmology; scaffold and cell therapy; and drug delivery and vaccines

용도

Flocculant, protein precipitation, encapsulating agent and aqueous thickener.

용도

also available in pharma grade

용도

chitosan is a film-forming polysaccharide that can aid the skin’s moisture content and moisture-retention capacity by preventing transepidermal water loss. In addition, it appears to help bind other ingredients (for example, to increase liposome stability), thereby increasing the availability of active ingredients to the skin. Anti-bacterial properties are also associated with chitosan, as well as an ability to enhance the microbiological stability of a preparation. Some studies show that it can help improve the water-resistance properties of sun protection creams and lotions, and the longevity of a fragrance’s scent (the perfume adheres more strongly to the skin and evaporates more slowly, over a longer period). It acts as a skin conditioner, improving skin softness and suppleness. It may be found in moisturizers, sunscreens, and acne preparations, in addition to hair care products. It is the decarboxylated form of chitin and can hold water without creating a feeling of tackiness in a cosmetic preparation. According to some chitosan suppliers, the use of shrimp shells is one of the most important sources. They consist of 30–35 percent protein, 30–35 percent minerals, and 15–20 percent chitin, with some traces of lipids, dyes, and soluble proteins.

생산 방법

Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents.

Pharmaceutical Applications

Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.

Safety

Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable.
LD50 (mouse, oral): >16 g/kg

저장

Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃.

비 호환성

Chitosan is incompatible with strong oxidizing agents.

Regulatory Status

Chitosan is registered as a food supplement in some countries.

키토산 준비 용품 및 원자재

원자재

준비 용품


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