키토산

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키토산 MSDS

Chitosan

키토산 C화학적 특성, 용도, 생산

존재

게나 가재, 새우 등 갑각류가 가지고 있는 성분인 키틴을 인체 내에서 흡수하기 위해 탈아세틸화 시켜 얻어낸 물질로서 1811년 프랑스의 화학자 앙코 브라코노가 버섯에서 키틴을 발견한 것을 바탕으로 1859년 화학자 루게가 키틴을 틸아세틸화하여 만들어 냈고 1894년에 과학자 후페 자이라가 이 물질을 키토산이라 명명했다. 화학적으로 본다면, 포도당에서 수소 하나를 아민기로 대체한 것을 사슬 형태로 이어놓은 꼴이다.

개요

우선적으로 콜레스테롤에 관련해서 효과가 좋다. 체내에 과잉된 유해 콜레스테롤을 흡착, 배설하는 역할 즉 탈콜레스테롤 작용을 한다. 혈관 질환을 예방 및 개선하는데 큰 효과가 있다고 이미 식약청에서 인정된 바 있다. 또한 암 세포의 증식을 억제하는 항암 작용을 하는데 직접적인 암 세포 파괴가 아닌 면역력 강화와 비정상 세포에 흡착하여 암 세포의 증식과 성장을 방해하는 역할을 한다. 매우 좋다. 무튼 주 효능은 위에 서술된 세 가지가 제일 크고 이외에도 피부 및 모발에 좋으며 항균, 항바이러스 작용, 오염 물질 배출, 간 기능 개선, 혈당조절 등의 자잘한 효과도 가지고 있다고.

순도시험

  (1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 10.0ppm 이하이어야 한다.

  (3) 탈아세틸화도 : 이 품목을 건조한 다음 0.5g을 정밀히 달아 5v/v% 초산에 녹여 정확히 100mL로 하여 시험용액으로 한다. 이 키토산초산 시험용액 1mL를 200mL 삼각플라스크에 취하고 이에 물 30mL를 가하여 교반혼합한 다음 지시약으로서 0.1% 톨루이딘블루용액 2～3방울을 가해주고 0.0025N 폴리비닐황산칼륨용액으로 적정하여 다음 계산식에 따라 탈아세틸화도를 구할 때, 그 양은 70.0% 이상이어야 한다.

탈아세틸화도(%) ＝X/161/(X/161 ＋ Y/203)×100

X =1/400×1/1.000×f × 161×v

Y =0.5×0.01 - X

v : 0.0025N 폴리비닐황산칼륨용액 소비량(mL)

f : 0.0025N 폴리비닐황산칼륨용액 규정도계수

확인시험

  이 품목 0.2g에 안트론시액 5mL 및 물 1mL를 가하여 수욕상에서 가열할 때, 액은 청～녹색을 나타낸다.

정의

정    의  이 품목은 키틴을 알칼리처리하여 얻어지는 것으로서 그 성분은 폴리글루코사민(polyglucosamine)이다.

강열잔류물

  이 품목을 건조물로 환산하여 강열잔류물시험법에 따라 시험할 때, 그 양은 5% 이하이어야 한다.

화학적 성질

Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’.

출처

Chitosan comes from the shell of marine crustaceans.

용도

Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.Flocculant, protein precipitation, encapsulating agent and aqueous thickener.
Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application.
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

생산 방법

Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents.

benefits

Chitosan is a fibrous substance that might reduce how much fat and cholesterol the body absorbs from foods. It also helps blood clot when applied to wounds.

일반 설명

Chitosan is a linear amino polysaccharide composed of approximately 20% β1,4-linked N-acetyl-D-glucosamine (GlcNAc) and approximately 80% β1,4-linked D-glucosamine (GlcN) that is prepared by the partial deacetylation of chitin in hot alkali.

Pharmaceutical Applications

Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.

Safety

Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable.
LD₅₀ (mouse, oral): >16 g/kg

저장

Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃.

비 호환성

Chitosan is incompatible with strong oxidizing agents.

Regulatory Status

Chitosan is registered as a food supplement in some countries.

키토산 준비 용품 및 원자재

원자재

준비 용품

키토산 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	816	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Hubei Aumei New Material Co., Ltd.	+86-027-87366298 +8615927270571	tianyi@skbiology.cn	China	294	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Maanshan Tiantai Biotechnology Co., Ltd.	+86-0555-8889890 +86-17356584060	GM@tiantaibio-tech.com	China	72	58
Junwee Chemical co., Ltd.	+86-571-85808636 +86-13958122542	sales@junweechem.com	China	821	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	290	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58

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