7-Azaindole
|
|
7-Azaindole 속성
- 녹는점
- 105-107 °C (lit.)
- 끓는 점
- 270 °C (753.1004 mmHg)
- 밀도
- 1.1151 (rough estimate)
- 굴절률
- 1.5500 (estimate)
- 인화점
- 270°C
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 클로로포름, 메탄올에 용해됨
- 산도 계수 (pKa)
- 7.69±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- BRN
- 109667
- InChIKey
- MVXVYAKCVDQRLW-UHFFFAOYSA-N
- CAS 데이터베이스
- 271-63-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36-41-37/38-22 | ||
| 안전지침서 | 39-26-36/37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | UY8710000 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29339990 |
7-Azaindole C화학적 특성, 용도, 생산
화학적 성질
Brown-Cyrstalline Solid용도
7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.
주요 응용
7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.제조 방법
Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.Purification Methods
Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]7-Azaindole 준비 용품 및 원자재
원자재
준비 용품
2-(2,3-DIHYDRO-1BENZENESULFONYL-PYRROLO[2,3-B]PYRIDIN-3-YL)ETHANAMINE
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
4-IODO-7-AZAINDOLE
1H-Pyrrolo[2,3-b]pyridine, 4-nitro-, 7-oxide
4-Bromo-7-azaindole
4-Chloro-7-azaindole
7-OXIDE-7-AZAINDOLE
5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE
5-Bromo-7-azaindole
2-(2,3-DIHYDRO-1-BENZENESULFONYL-PYRROLO[2,3-B]PYRIDIN-3-YL)ACETONITRILE
4-CYANO-7-AZAINDOLE
1,7-DIDEAZAADENINE
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
3-Bromo-7-azaindole
1H-PYRROLO[2,3-B]PYRIDINE, 4-NITRO-
2-(2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraen-7-yl)ethanamine
4-HYDROXYMETHYL-7-AZAINDOLE
5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
1-(Benzenesulfonyl)-3-bromo-1H-pyrrolo[2,3-b]pyridine
7-Azaindole 공급 업체
글로벌( 671)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 |
shivshanghai@yahoo.com | India | 132 | 58 |
| Hunan aslsen technology co.,ltd | +8619313031929 |
aslsd@aslsen.com | China | 128 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5964 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |