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O-페닐렌다이아민

O-페닐렌다이아민
O-페닐렌다이아민 구조식 이미지
카스 번호:
95-54-5
한글명:
O-페닐렌다이아민
동의어(한글):
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상품명:
o-Phenylenediamine
동의어(영문):
OPD;ik3;OPDA;PODA;ek1700;sq15500;EK 1700;nsc5354;OPD EASY;NSC 5354
CBNumber:
CB9854699
분자식:
C6H8N2
포뮬러 무게:
108.14
MOL 파일:
95-54-5.mol

O-페닐렌다이아민 속성

녹는점
100-102 °C
끓는 점
256-258 °C
밀도
1,27 g/cm3
증기 밀도
3.7 (vs air)
증기압
0.01 mm Hg ( 25 °C)
굴절률
1.6339 (estimate)
인화점
110°C
저장 조건
2-8°C
용해도
H2O: 1 tablet/10 mL, clear, colorless
물리적 상태
tablet
색상 색인 번호
76010
산도 계수 (pKa)
4.46(at 25℃)
색상
white to off-white
pH 범위
Green Q uorescence (3.1) to nonQ uorescence (4.4)
수소이온지수(pH)
7-8 (50g/l, H2O, 20℃)
폭발한계
1.5%(V)
수용성
<0.1 g/100 mL at 20 ºC
감도
Air & Light Sensitive
Merck
14,7284
BRN
606074
노출 한도
TLV-TWA 0.1 mg/m3; carcinogenicity: A2- Suspected Human Carcinogen (ACGIH 1989).
안정성
Stable. Incompatible with strong oxidizing agents.
주요 응용
bottom antireflective coatings, semiconductor devices, hair dyes, detecting antibody, substrate for horseantibody, glucose, streptomycin, penicillin, sulfonamide, neuroglobin, substrate for horseradish peroxidase
CAS 데이터베이스
95-54-5(CAS DataBase Reference)
NIST
1,2-Benzenediamine(95-54-5)
IARC
2B (Vol. 123) 2020
EPA
1,2-Phenylenediamine (95-54-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,N
위험 카페고리 넘버 20/21-25-36-40-43-50/53-68
안전지침서 28-36/37-45-60-61-1/2
유엔번호(UN No.) UN 1673 6.1/PG 3
WGK 독일 3
RTECS 번호 SS7875000
F 고인화성물질 8-10-23
자연 발화 온도 540 °C
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29215119
유해 물질 데이터 95-54-5(Hazardous Substances Data)
독성 LD50 in rats (mg/kg): 1070 orally; 516 i.p., C. Burnett et al., J. Toxicol. Environ. Health 2, 657 (1977)
기존화학 물질 KE-02174
유해화학물질 필터링 97-1-334
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 페닐렌디아민과 그 염류 및 이를 25% 이상 함유한 혼합물
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H400 수생생물에 매우 유독함 수생 환경유해성 물질 - 급성 구분 1 경고 P273, P391, P501
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
0 0

O-페닐렌다이아민 MSDS


C.I. Oxidation base 16

O-페닐렌다이아민 C화학적 특성, 용도, 생산

화학적 성질

White to off white solid

화학적 성질

o-Phenylenediamine is a white to brownish crystalline substance that turns red upon exposure to air.

용도

m-Phenylenediamine is used in the manu facture of a variety of dyes, in hair dyeformulations, as a rubber curing agent, inpetroleum additives, as a photographic developing agent, and as an analytical reagent.

용도

o-Phenylenediamine is used as an intermediate in the manufacture of dyes, pigments, andfungicides. It is also used in hair dye formulation, as a photographic developing agent,and in organic synthesis.

용도

o-Phenylenediamine is an amino substituted benzene used in the manufacture of dyes. Potential use in sensitive immunosensor for cancer biomarker.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

용도

It is actively involved in the preparation of pharmaceuticals by reacting substituted o-phenylenediamine with various diketones.

용도

Manufacture of dyes.

정의

ChEBI: A phenylenediamine in which the two amino groups are ortho to each other.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 501, 1943
Synthetic Communications, 25, p. 4025, 1995 DOI: 10.1080/00397919508011478

일반 설명

Colorless monoclinic crystals if pure; technical grade brownish-yellow crystals or a sandy brown solid. Used in manufacture of dyes, photography, organic synthesis.

공기와 물의 반응

Soluble in water [Hawley]. Melting point 219 F. Flash point 277 F. Toxic by skin absorption, inhalation or ingestion. Even as a solid will spot downwind area brown/purple (Roger Patrick, DuPont Engineer).

반응 프로필

o-Phenylenediamine a weak aromatic amine base neutralizes acids in exothermic reactions to form salts. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Darkens on exposure to air (Roger Patrick, DuPont Engineer).

건강위험

The toxic effects of m-phenylenediamineare similar to its ortho- and para-isomers.The toxic symptoms were tremor, excite ment, convulsions, and cyanosis, and col lapse at fatal dose. Other symptoms includeddecreased blood pressure and pulse rate.Chronic toxic effects resulting from the oralapplication of an aqueous solution of thiscompound were increase in liver and to alesser extent, kidney weights. No carcinogenicity was observed in test animals. Thecompound was excreted rapidly, unchanged.
LD50 value, oral (rats): 650 mg/kg.

화재위험

Flash point data for o-Phenylenediamine are not available. o-Phenylenediamine is probably combustible.

Biochem/physiol Actions

o-Phenylenediamine (o-PD) is a potent substrate for spectrophotometric horseradish peroxidase (HRP)-mediated enzyme-linked immunosorbent assay (ELISA), which gives 2,3-diaminophenazine (DAP) as a product of o-PD oxidation.

Safety Profile

Confirmed carcinogen. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Mildly toxic by skin contact. Mutation data reported. A pesticide and pharmaceutical. When heated to decomposition it emits toxic fumes of NOx. See also other phenylenediamine entries and AMINES

잠재적 노출

Used as an intermediate in the making of dyes; pesticides, pharmaceuticals, and rubber chemicals; in making fungicides and other chemicals; in photographic and analytical procedures and processes

Carcinogenicity

o-PDA (dihydrochloride) induced hepatocellular carcinomas during an 18-month feeding study in male Charles River CD rats given diets containing 2000 or 4000 ppm of the chemical (female rats not used in this study). No significant carcinogenic effects were observed in male and female CD-1 mice given higher doses (6872 or 13,743 ppm) of the compound.

운송 방법

UN1673 Phenylenediamines (o-, m-, p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise the diamine from aqueous 1% sodium hydrosulfite (charcoal), wash it with ice-water and dry it in a vacuum desiccator, or sublime it in vacuo. It has been purified by recrystallisation from toluene and zone refined [Anson et al. J Am Chem Soc 108 6593 1986]. Purification by refluxing a CH2Cl2 solution containing charcoal is also carried out followed by evaporation and recrystallisation [Koola & Kochi J Org Chem 52 4545 1987], protect from light. The acetate has m 186o. [Beilstein 13 IV 38.]

비 호환성

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates. Heat and light contribute to instability. Keep away from metals; 1,2-PHENYLENEDIAMINE a weak aromatic amine base neutralizes acids in exothermic reactions to form salts. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Darkens on exposure to air (Roger Patrick, DuPont Engineer).

폐기물 처리

Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.

O-페닐렌다이아민 준비 용품 및 원자재

원자재

준비 용품


O-페닐렌다이아민 공급 업체

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Masteam Bio-tech Co., Ltd.
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
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+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com China 1807 55
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008615858145714
+86-571-56059825 fandachem@gmail.com China 9156 55
ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
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