ChemicalBook
Chinese English Japanese Germany Korea

8-하이드록시퀴놀린

8-하이드록시퀴놀린
8-하이드록시퀴놀린 구조식 이미지
카스 번호:
148-24-3
한글명:
8-하이드록시퀴놀린
동의어(한글):
8-히드록시퀴놀린;퀴노페놀;페노피리딘;8-퀴놀리놀;8-하이드록시퀴놀린;바이오퀸;옥시-벤조피리딘;옥시퀴놀린;옥신;하이드록시벤조피리딘;하이드록시-8-퀴놀린;1-아자나프탈렌-8-올;8-치놀리놀;옥시벤조피리딘;옥시치놀린;페놀피리딘;하이드록시퀴놀린
상품명:
8-Hydroxyquinoline
동의어(영문):
OQ;8-OQ;Oxin;Tumex;OXINE;8-Oxine;BIOQUIN;8-Quinol;Fennosan;NSC 2039
CBNumber:
CB8435187
분자식:
C9H7NO
포뮬러 무게:
145.16
MOL 파일:
148-24-3.mol

8-하이드록시퀴놀린 속성

녹는점
70-73 °C(lit.)
끓는 점
267 °C752 mm Hg(lit.)
밀도
1.0340
굴절률
1.4500 (estimate)
인화점
267°C
저장 조건
Store at RT.
용해도
0.56g/l
산도 계수 (pKa)
5.017(at 20℃)
물리적 상태
Liquid
색상
White to pale yellow or light beige
수용성
INSOLUBLE
감도
Light Sensitive
Merck
14,4843
BRN
114512
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N
CAS 데이터베이스
148-24-3(CAS DataBase Reference)
NIST
8-Quinolinol(148-24-3)
IARC
3 (Vol. 13, Sup 7) 1987
EPA
8-Quinolinol (148-24-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-68-36/37/38
안전지침서 45-36/37/39-26-36
유엔번호(UN No.) 2811
WGK 독일 3
RTECS 번호 VC4200000
위험 참고 사항 Harmful/Irritant
TSCA Yes
위험 등급 9
포장분류 III
HS 번호 29334990
유해 물질 데이터 148-24-3(Hazardous Substances Data)
독성 An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963).
기존화학 물질 KE-30043
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
2 0

8-하이드록시퀴놀린 MSDS


8-Quinolinol

8-하이드록시퀴놀린 C화학적 특성, 용도, 생산

화학적 성질

8-Hydroxyquinoline is a white to cream-colored crystal or crystalline powder that is insoluble in water or ether and freely soluble in ethanol, acetone, chloroform, benzene, and aqueous mineral acids. It readily forms stable metal chelates, which are soluble or precipitable in organic solvents, depending on the pH of the solution (Hollingshead, 1954).

Originator

Chinosol,Chinosolfabrik

용도

Oxine is an almost universal complexing agent; it reacts with very many metal ions to give water-insoluble precipitates. It has been used so far for the determination of aluminium, antimony, beryllium, bismuth, cadmium, cerium, cobalt, chromium, copper, gallium, germanium, lanthanum, lithium, magnesium, manganese, molybdenum, nickel, ruthenium, thorium, titanium, uranium, vanadium, tungsten, zinc and zirconium.
With the exception of the aluminium, bismuth, gallium, indium, lead and thallium complexes, the oxinate precipitates contain water of crystallization. The majority of the complexes are of stoichiometric composition (either with or without water of crystallization), and therefore subsequent to drying at suitable temperature the precipitates are ready for direct weighing. The precipitates containing water of crystallization are usually dried at 100-105°C and weighed as such, or dried at 130-140°C when the water of crystallization is eliminated.
The complexes can be decomposed with strong acids, and the oxine liberated in an amount equivalent to the metal may be determined by bromatometric titration.
The electrically neutral oxinate complexes are sparingly soluble in water whereas they readily dissolve in apolar solvents immiscible with water, for instance chloroform. Hence this ligand is useful for the solvent extraction enrichment and the subsequent spectrophotometric determination of metal ions. The optimum pH range for complex formation is dependent upon the stabilities of the oxinate complexes. Accordingly, divalent metals are usually precipitated quantitatively in neutral or slightly alkaline media. Adjustment of the suitable pH may be made with various tartrate buffers, for example with ammonia-ammonium tartrate in the pH range 6-10, and with sodium hydroxidesodium tartrate buffers for the pH range 10-13. Complexes of tri- and tetravalent metals are more stable, and thus can be precipitated quantitatively even at about pH 4. In these cases the pH of the solution is adjusted to the desired value with acetic acid-sodium acetate buffers. The copper(II) and iron(III) complexes precipitate quantitatively even at pH 2.7, as does vanadium(V) as an oxinate complex of uncertain composition.

용도

8-Hydroxyquinoline has a wide variety of uses. Primarily because of their metal chelating properties, 8-hydroxyquinoline and its salts, halogenated derivatives, and metal complexes have been used as analytical reagents (Hollingshead, 1954) and as antimicrobial agents in medicine, fungicides, and insecticides (Harvey, 1975). It is also used as a preservative in cosmetics and tobacco, a chemical intermediate in dye synthesis (IARC, 1977), and a precipitating reagent for uranium and other radioactive metals in nuclear power plant liquid waste effluent. It is used in nuclear medicine with indium-111 (Davis et al., 1978).
8-Hydroxyquinoline may be used as a chelating ligand in the preparation of tris-(8-hydroxyquinoline)aluminum (Alq3), an organic electroluminescent compound used in organic light-emitting devices (OLEDs).

정의

ChEBI: A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.

Manufacturing Process

The mixture of 1.4 kg o-nitrophenol, 2.1 kg o-aminophenol, 6 kg glycerine (d = 1.26) and 5 kg sulfuric acid (d = 1.848) was heated at reflux to temperature 130°-140°C. This temperature was kept for 1.5 hours. The obtained oxyquinoline precipitated, the liquid was removed with water-steam distillation. The residue was diluted with water and alkalized with sodium hydroxide and sodium carbonate to the strong alkaline reaction. The repeated distillation with water steam gave the oil, which hardened as the long needles by cooling. MP: 75°-76°C recrystallized from diluted ethanol.
In practice it is usually used as sulfate salt

상표명

Aci-jel;Benzease;Chinosol;Cp-cap;Dermacid;Dermoplast;Fennosan h 30;Heriat;Hydroxybenoxopyridine;Medicone derma-hc;Oxykin;Oxyquinoline-rhp;Pedivol;Phenopyridine;Preconsol;Quinoderm;Quinoped;Quinophenol;Recta medicone-hc;Semori;Serohinol;Serorhinol;Superol;Trimo-san;Triva douch powder;Triva jel.

Therapeutic Function

Antiseptic

World Health Organization (WHO)

Halogenated hydroxyquinoline is structurally related to clioquinol. See WHO comment for clioquinol. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)

일반 설명

White to off-white or faintly yellow crystalline powder. Phenolic odor.

공기와 물의 반응

Insoluble in water.

반응 프로필

8-Hydroxyquinoline darkens on exposure to light. 8-Hydroxyquinoline readily forms stable metal chelates. 8-Hydroxyquinoline is incompatible with strong oxidizers. 8-Hydroxyquinoline is also incompatible with many metal ions.

위험도

Toxic by ingestion. Questionable carcinogen.

화재위험

Flash point data for 8-Hydroxyquinoline are not available; however, 8-Hydroxyquinoline is probably combustible.

Clinical Use

Oxine, quinophenol, or oxyquinoline is the parent compoundfrom which the antiprotozoal oxyquinolines havebeen derived. The antibacterial and antifungal properties of oxine and its derivatives, which are believed to result fromthe ability to chelate metal ions, are well known. Aqueoussolutions of acid salts of oxine, particularly the sulfate(Chinosol, Quinosol), in concentrations of 1:3,000 to1:1,000, have been used as topical antiseptics. The substitutionof an iodine atom at the 7-position of 8-hydroxyquinolinesyields compounds with broad-spectrum amebicidalproperties.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. A central nervous system stimulant. Human mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits hghly toxic fumes of NOx.

Purification Methods

Crystallise oxine from hot EtOH, acetone, pet ether (b 60-80o) or water. Crude oxine can be purified by precipitation of copper oxinate, followed by liberation of free oxine with H2S or by steam distillation after acidification with H2SO4. Store it in the dark. It forms complexes with many metals. [Manske et al. Can J Research 27F 359 1949, Phillips Chem Rev 56 271 1956, Beilstein 21 III/IV 1135, 21/3 V 252.]

8-하이드록시퀴놀린 준비 용품 및 원자재

원자재

준비 용품


8-하이드록시퀴놀린 공급 업체

글로벌( 684)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
info@zzyuanli.cn CHINA 136 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2911 55
Tangshan Moneide Trading Co., Ltd.
86-315-8309571 15633399667
sales@moneidechem.com CHINA 532 58
Career Henan Chemica Co
13203830695 0371-86658258
0371-86658258 Laboratory@coreychem.com CHINA 30287 58
Shandong Natural Micron Pharm Tech Co.,LTD
13752232623
info@nmpharmtech.com CHINA 2271 58
Wuhan Shuokang Biological Technology Co.,Ltd
86-02787366298
+8615927270571 postmaster@skbiology.cn CHINA 133 58
Springchem New Material Technology Co.,Limited
86-21-51752791
86-21-51752789 info@spring-chem.com China 2063 57
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55

8-하이드록시퀴놀린 관련 검색:

Copyright 2019 © ChemicalBook. All rights reserved