8-하이드록시퀴놀린
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8-하이드록시퀴놀린 속성
- 녹는점
- 70-73 °C(lit.)
- 끓는 점
- 267 °C752 mm Hg(lit.)
- 밀도
- 1.0340
- 증기압
- 0.221Pa at 25℃
- 굴절률
- 1.4500 (estimate)
- 인화점
- 267°C
- 저장 조건
- Store below +30°C.
- 용해도
- 0.56g/L
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- 5.017(at 20℃)
- 색상
- 흰색에서 연한 노란색 또는 연한 베이지색
- 수용성
- 불용성
- 감도
- Light Sensitive
- Merck
- 14,4843
- BRN
- 114512
- InChIKey
- MCJGNVYPOGVAJF-UHFFFAOYSA-N
- LogP
- 1.85 at 25℃
- CAS 데이터베이스
- 148-24-3(CAS DataBase Reference)
- IARC
- 3 (Vol. 13, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-68-36/37/38 | ||
안전지침서 | 45-36/37/39-26-36 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | VC4200000 | ||
위험 참고 사항 | Harmful/Irritant | ||
TSCA | Yes | ||
위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 29334990 | ||
유해 물질 데이터 | 148-24-3(Hazardous Substances Data) | ||
독성 | An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963). | ||
기존화학 물질 | KE-30043 |
8-하이드록시퀴놀린 C화학적 특성, 용도, 생산
화학적 성질
8-Hydroxyquinoline is a white to cream-colored crystal or crystalline powder that is insoluble in water or ether and freely soluble in ethanol, acetone, chloroform, benzene, and aqueous mineral acids. It readily forms stable metal chelates, which are soluble or precipitable in organic solvents, depending on the pH of the solution (Hollingshead, 1954).용도
8-Hydroxyquinoline has a wide variety of uses. Primarily because of their metal chelating properties, 8-hydroxyquinoline and its salts, halogenated derivatives, and metal complexes have been used as analytical reagents (Hollingshead, 1954) and as antimicrobial agents in medicine, fungicides, and insecticides (Harvey, 1975). It is also used as a preservative in cosmetics and tobacco, a chemical intermediate in dye synthesis (IARC, 1977), and a precipitating reagent for uranium and other radioactive metals in nuclear power plant liquid waste effluent. It is used in nuclear medicine with indium-111 (Davis et al., 1978).정의
ChEBI: 8-Hydroxyquinoline is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline.제조 방법
8-Hydroxyquinoline is synthesized from o-aminophenol by cyclization reaction. Add glycerin into the acid-resistant reaction pot, slowly add concentrated sulfuric acid under stirring, and simultaneously add o-aminophenol and o-nitrophenol in sequence, and add 65% of the total oleum first. Heat up to 125°C, stop heating, naturally heat up to 140°C, and wait until the temperature returns to 136°C. The rest of the oleum was continued to be added, maintaining the temperature at 137°C. After adding acid, keep warm for 4 hours, cool to below 100°C, pump into an acid-resistant pot containing 10 times the amount of water (calculated by o-aminophenol), stir, heat to 75-80°C, use 30% sodium hydroxide The solution was neutralized to pH 7-7.2. The precipitate is released while hot, cooled into a block, and sublimed under reduced pressure to obtain the finished product of 8-hydroxyquinoline.주요 응용
8-Hydroxyquinoline may be used as a chelating ligand in the preparation of tris-(8-hydroxyquinoline)aluminum (Alq3), an organic electroluminescent compound used in organic light-emitting devices (OLEDs).World Health Organization (WHO)
Halogenated hydroxyquinoline is structurally related to clioquinol. See WHO comment for clioquinol. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)일반 설명
White to off-white or faintly yellow crystalline powder. Phenolic odor.공기와 물의 반응
Insoluble in water.반응 프로필
8-Hydroxyquinoline darkens on exposure to light. 8-Hydroxyquinoline readily forms stable metal chelates. 8-Hydroxyquinoline is incompatible with strong oxidizers. 8-Hydroxyquinoline is also incompatible with many metal ions.위험도
Toxic by ingestion. Questionable carcinogen.Clinical Use
8-Hydroxyquinoline (8HQ) is an intermediate of halogenated quinoline anti-amebic drugs, including quiniodoform, clioquinoline, diiodoquinoline and the like. These drugs exert anti-amebic effects by inhibiting intestinal commensal bacteria, and are effective against amoebic dysentery, but have no effect on extra-intestinal amoebic parasites.8HQ is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities.Safety Profile
8-Hydroxyquinoline (8-HQ) may be a skin irritant in man. Hair depigmentation was seen in mice treated dermally. Dilute solutions were slightly irritating to the eyes of rabbits. In cases of human poisoning (by ingestion or by the administration of an enema containing 8-HQ or its sulphate), the kidney, liver and blood were the principal sites of toxic attack. Comprehensive studies involving repeated oral administration of 8-HQ to rodents failed to identify any particular sites for toxic attack and provided no convincing evidence of carcinogenicity. 8-HQ induced chromosomal damage in mammalian cells in culture (including human cells), but gave conflicting results in mice treated intraperitoneally. Both 8-HQ and its sulphate have induced mutagenicity in Ames bacterial tests and there was some evidence of mutagenic activity in mammalian cells treated in culture.Purification Methods
Crystallise oxine from hot EtOH, acetone, pet ether (b 60-80o) or water. Crude oxine can be purified by precipitation of copper oxinate, followed by liberation of free oxine with H2S or by steam distillation after acidification with H2SO4. Store it in the dark. It forms complexes with many metals. [Manske et al. Can J Research 27F 359 1949, Phillips Chem Rev 56 271 1956, Beilstein 21 III/IV 1135, 21/3 V 252.]8-하이드록시퀴놀린 준비 용품 및 원자재
원자재
준비 용품
8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
8-Hydroxyquinoline-5-sulfonic acid
8-hydroxyquinoline dithiophosphate complex
디아이오딘하이드록시퀴놀린
5-Methoxymethyl-2,3-pyridinedicarboxylic acid
ribonucleic acid for injection
8-히드록시-2-퀴놀린카보니트릴
5-클로로-8-하이드록시퀴놀린
옥신-구리
8-히드록시-7-요오드-퀴노린술폰산
5,7-Dichloro-8-hydroxyquinoline
5,7-DIBROMO-8-HYDROXYQUINOLINE
8-hydroxy-decahydroquinoline
6,7-디클로로퀴놀린-5,8-디온
2-Naphthalenesulfonic acid, 4-hydroxy-3-[(2-hydroxy-4-nitrophenyl)azo]-7-[(8-hydroxy-5-quinolinyl)azo]-, monosodium salt
[4-Chloro-2-[[1-hydroxy-6-[[4-[(8-hydroxy-5-quinolinyl)azo]benzoyl]amino]-3-sulfo-2-naphtyl]azo]phenoxy]acetic acid
Chromium, 3-[(8-hydroxy-5-quinolinyl)azo]benzenesulfonic acid complex
Mordant Orange 26
8-하이드록시퀴놀린 공급 업체
글로벌( 958)공급 업체
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Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
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Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
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Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
8-하이드록시퀴놀린 관련 검색:
8-히드록시-5-니트로퀴노린 퀸하이드론 옥신-구리 8-하이드록시퀴놀린 설페이트 8-하이드록시퀴놀린 N-산화물 크산투렌산 퀴놀린 2,4-퀴놀린디올 8-하이드록시퀴놀린
5-Chloro-8-hydroxyquinoline
7-Bromoquinoline
8-Hydroxyquinoline aluminum salt
Bis(8-quinolinolato) zinc
8-Hydroxyquinoline-5-sulfonic acid
8-ETHOXYQUINOLINE-5-SULFONIC ACID SODIUM SALT
broquinaldol
9-HYDROXY-4-METHOXYACRIDINE
8-HYDROXYQUINOLINE, MG