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Cilastatin

Cilastatin
Cilastatin structure
CAS No.
82009-34-5
Chemical Name:
Cilastatin
Synonyms
mk-791;Cilastain;CILASTATIN;Cilistatin Acid;Cilastatin acid;CILASTATIN (MK0791);Cilastatin USP/EP/BP;Cilastatin AMMoniuM Salt;(r-(r*,s*-(z)))-)carbonyl)amino);(Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic acid
CBNumber:
CB2781013
Molecular Formula:
C16H26N2O5S
Formula Weight:
358.45
MOL File:
82009-34-5.mol

Cilastatin Properties

Melting point:
156-158°C
Boiling point:
655.5±55.0 °C(Predicted)
Density 
1.275±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka
2.09±0.10(Predicted)
CAS DataBase Reference
82009-34-5(CAS DataBase Reference)
FDA UNII
141A6AMN38

Cilastatin price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1134051 Cilastatin ammonium salt United States Pharmacopeia (USP) Reference Standard 82009-34-5 100 mg $366 2021-03-22 Buy
Cayman Chemical 23511 Cilastatin ≥98% 82009-34-5 10mg $39 2021-03-22 Buy
Cayman Chemical 23511 Cilastatin ≥98% 82009-34-5 50mg $176 2021-03-22 Buy
Cayman Chemical 23511 Cilastatin ≥98% 82009-34-5 100mg $332 2021-03-22 Buy
Cayman Chemical 23511 Cilastatin ≥98% 82009-34-5 250mg $634 2021-03-22 Buy

Cilastatin Chemical Properties,Uses,Production

Chemical Properties

White to Light-Yellow Crystalline Powder

Uses

Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct

Uses

spectrum antibiotic

Uses

Cilastatin is used for treating diseases caused by polyresistant Gram-negative microorganisms and serious complex infections, including infection of S. aureus. Because of its strong activity against anaerobic bacteria, cilastatin is effective in monotherapy of intraabdominal infections. It is used for infectious diseases of the lower respiratory tract, urinary tract, gynecological infections, bacterial septicemia, and infections of the bones, skin, and so on.

Chemical Synthesis

Cilastatin, (Z)-7-[(2-amino-2-carboethoxyethyl)thio]-2-[[2,2-dimethylcyclopropyl) carbonyl] amino]-2-heptenoic acid (32.1.3.6), is synthesized from the ethyl ester of 1,3-dithian-2-carboxylic acid (which is ethyl glyoxylate, protected at the aldehyde group with 1,3-propanedithiol), which is alkylated by 1,5-dibromopentane in the presence of sodium amide, forming the ethyl ester of 7-bromo-2-[2-(1,3-dithiano)]hepthanoic acid (32.1.3.2). Oxidative hydrolysis of this product with N-bromosuccinimide in a mixture of acetonitrile–water solvents leads to the formation of the ethyl ester of 7-bromo-α-ketoheptanoic acid (32.1.3.3). Acidic hydrolysis of this product using hydrogen bromide in acetic acid gives 7-bromo-α-ketoheptanoic acid (32.1.3.4). This is reacted with 2,2-dimethylcyclopropancarboxylic acid amide to form the corresponding enamide, (Z)-7-bromo-2-(2, 2-dimethylcycloprotancarboxamido)-2-heptenoic acid (32.1.3.5). The resulting product is used for S-alkylation of L-cysteine, which results in the production of the desired cilastatin (32.1.3.6).

Cilastatin Preparation Products And Raw materials

Raw materials

Preparation Products


Cilastatin Suppliers

Global( 152)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58

View Lastest Price from Cilastatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Cilastatin
82009-34-5
US $180.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-08-26 Cilastatin
82009-34-5
US $80.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-07-20 Cilastatin
82009-34-5
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

82009-34-5(Cilastatin)Related Search:


  • Cilistatin Acid
  • (z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid
  • (r-(r*,s*-(z)))-)carbonyl)amino)
  • mk-791
  • CILASTATIN
  • Cilastain
  • (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid
  • Cilastatin acid
  • [R-[R^<*>^,S^<*>^(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid
  • (Z)-7-[[(R)-2-Amino-2-carboxyethyl]thio]-2-[[[(S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
  • Cilastatin AMMoniuM Salt
  • CILASTATIN (MK0791)
  • 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)-
  • (Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic acid
  • Cilastatin USP/EP/BP
  • 82009-34-5
  • C16H26N2O5S
  • Inhibitors
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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