Nadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is
indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a
potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria
and against anaerobic bacteria. It produces significant improvement in patients with
Propionibacterium acnes infection and does not appear to cause cross-resistance to other
antibiotic agents. Its potent antimicrobial activity has also been demonstrated in the
Pseudomonas aeruginosa burn wound infection model in mice. Nadifloxacin exerts its
antibiotic activity by inhibiting the formation of supercoiled DNA by DNA gyrase.
화학적 성질
Off-White Crystalline Solid
용도
Nadifloxacin is a topical fluorinated quinolone antibacterial used to treat skin conditions such as acne and other dermal infections caused by bacteria. This drug belongs to a class of calcium salt of polyacrylic acid crosslinked with divinyl glycol with minimal AEs.
정의
ChEBI: Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.
Pharmaceutical Applications
A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.
