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O-페난트롤린

O-페난트롤린
O-페난트롤린 구조식 이미지
카스 번호:
66-71-7
한글명:
O-페난트롤린
동의어(한글):
o-페난트롤린;1,10-페난트롤린
상품명:
o-Phenanthroline
동의어(영문):
phen;AKOS 92891;O-PHENANTHROLINE;1,10-Fenanthrolin;10-Phenanthroline;4,5-Phenanthroline;beta-Phenanthroline;ORTHOPHENANTHROLINE;1,10-PHENANTHROLINE;4,5-Diazaphenanthrene
CBNumber:
CB4283203
분자식:
C12H8N2
포뮬러 무게:
180.21
MOL 파일:
66-71-7.mol

O-페난트롤린 속성

녹는점
114-117 °C(lit.)
끓는 점
>330°C
밀도
1.1836 (rough estimate)
굴절률
1.5200 (estimate)
인화점
>330°C
저장 조건
Refrigerator
용해도
2.69g/l
산도 계수 (pKa)
4.84(at 25℃)
물리적 상태
Powder
색상
White to light yellow or light pink
수용성
slightly soluble
감도
Hygroscopic
Merck
14,7214
BRN
126461
안정성
Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents.
InChIKey
DGEZNRSVGBDHLK-UHFFFAOYSA-N
CAS 데이터베이스
66-71-7(CAS DataBase Reference)
NIST
o-Phenanthroline(66-71-7)
EPA
1,10-Phenanthroline(66-71-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,N
위험 카페고리 넘버 25-50/53
안전지침서 45-60-61
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 SF8437000
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29339990
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H400 수생생물에 매우 유독함 수생 환경유해성 물질 - 급성 구분 1 경고 P273, P391, P501
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P273 환경으로 배출하지 마시오.
P321 (…) 처치를 하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

O-페난트롤린 MSDS


o-Phenanthroline

O-페난트롤린 C화학적 특성, 용도, 생산

화학적 성질

off-white powder

용도

A chelating agent, forming complexes with most metal ions.

용도

A ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide.

용도

As an analytical reagent for determination of metals in chemical and biological systems through complex formation. As an indicator ("Ferroin") in combination with ferrous ions for oxidation/reduction reactions. In organic syntheses as an activator.

Safety Profile

Poison by ingestion and intraperitoneal routes. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

효소 저해제

This metal ion chelator (FWfree-base = 180.21 g/mol; CAS 66-71-7), also called o-phenanthroline, is especially effective as a zinc ion chelator. It is a relatively low-affinity reversible inhibitor that acts by chelating active-site metal ions in certain metal-activated and metalloenzymes. Given the fact that active-site metal ions are most often bound by multiple amino acid side-chains, one must consider the likelihood that 1,10-phenanthrolein will act slowly in a manner akin to most slow-binding enzyme inhibitors. Another consideration is that the observed inhibitory effect of 1,10- phenanthrolene has nothing to do with chelation but is simply a consequence ofd its hydrophobicity. (See comment under 4,7-Phenanthroline) The inhibitory range is typically 1–5 mM; however, some iron-dependent proteins are reportedly inhibited at 10–8 M. The reported Ki values for angiotensin I-converting-enzyme (peptidyl-dipeptidase A), thermolysin, and astacin are 6, 50, and 50 mM for, respectively. In addition to iron and zinc, it will also bind Mn, Co, Ni, Ag, Ru, and Cu. This chelator will also inhibit dioxygen production in photosynthesis and has been reported to exhibit nuclease activity when complexed with copper. The ferrous complex, frequently referred to as Ferroin and available commercially, is used as an indicator in oxidation/reduction systems. 1,10-Phenanthroline is hygroscopic and is usually supplied as the monohydrate (FW = 198.22 g/mol). It has a melting point of 93-94°C (anhydrous melting point = 117°C) and is soluble in about 300 parts water. It is typically prepared as 100-200 mM stock solution using dimethyl sulfoxide (preferred), methanol, or ethanol. Note: When testing for the inhibitory effects of 1,10- phenanthroline, a good practice is to also test 1,7-phenanthroline or 4,7- phenanthroline as controls for nonchelating binding effects. Another distinguishing feature is that metal ion resolution by 1,10-phenanthroline is typically time-dependent, whereas binding of non-chelating isomers is rarely time-dependent.

Purification Methods

Purify it via the HgCl2 addition compound formed when phenanthridine (20g) in 1:1 HCl (100mL) is added to aqueous HgCl2 (60g in 3L), and the mixture is heated to boiling. The HgCl2 complex separates as yellow red crystals with m 195-198o [Arcus & Mesley J Chem Soc 1780 1953]. Conc HCl is then added until all of the solid has dissolved. The compound separates on cooling and is decomposed with aqueous NaOH (ca 5M). Phenanthridine is extracted into Et2O, evaporated, and the residue is crystallised from pet ether (b 80-100o) or EtOAc. [Cumper et al. J Chem Soc 45218 1962.] It is also purified by chromatography on activated alumina from *benzene solution, with diethyl ether as eluent. Evaporation of ether gives crystalline material which is freed from residual solvent under vacuum, then further purified by fractional crystallisation, under N2, from its melt. It was purified by zone melting and sublimes in a vacuum. The picrate has m 218.5-219.5o (from iso-PrOH) (also reported are m 244-245o and 247-248o, from EtOH or H2O). [Slough & Ubbelhode J Chem Soc 911 1957.] [Beilstein 20 H 466, 20 III/IV 4016, 20/8 V 223.]

O-페난트롤린 준비 용품 및 원자재

원자재

준비 용품


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