ChemicalBook >제품 카탈로그 >N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 구조식 이미지

카스 번호:: 302964-08-5

상품명:: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

동의어(영문):: Dasatinib Int N-1;CAY10697;2-((6-ChL;)amino)-N-(2-chL;dasatinib Dichloro;Dasatinib Impurity M;Dasatinib EP Impurity-D;Dasatinib Intermediate 1;Dasatinib Dichloro Impurity;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl

CBNumber:: CB51473109

분자식:: C16H13Cl2N5OS

포뮬러 무게:: 394.28

MOL 파일:: 302964-08-5.mol

속성

안전

용도

공급 업체 287

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 속성

녹는점: 333-335°C

끓는 점: 566.95° C (Predicted)

밀도: 1.516±0.06 g/cm3(Predicted)

굴절률: n20D 1.72 (Predicted)

저장 조건: Inert atmosphere,2-8°C

용해도: DMSO (약간 용해됨)

산도 계수 (pKa): 10.92±0.70(Predicted)

물리적 상태: 고체

물리적 상태: 단단한 모양

색상: 옅은 노랑

수용성: Slightly soluble in water

InChI: InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)

InChIKey: LMXUWARKUIELGT-UHFFFAOYSA-N

SMILES: S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1

CAS 데이터베이스: 302964-08-5(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2933399990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	0
2		0

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide C화학적 특성, 용도, 생산

개요

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.

화학적 성질

Pale Yellow Solid

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 준비 용품 및 원자재

원자재

Thiourea, N-(6-chloro-2-methyl-4-pyrimidinyl)- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 4,6-Dichloro-2-methylpyrimidine

준비 용품

다사티닙

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 공급 업체

글로벌( 287)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	64	58
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580 +86-18001856580	2415195517@qq.com	China	43	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 관련 검색:

포름아미드 이염화파라콰트 N,N-다이메틸폼아마이드 메틸파라벤 쿠레톡심메틸 벤즈아마이드 메틸알콜 아세토나이트릴 아크릴산메틸 메틸 바이올렛 (2B) 클로로디플루오르메탄 2-(2-Aminothiazol-4-yl)glyoxylic acid Chlorantraniliprole (E)-3-Ethoxyacryloyl chloride N-(2-cyanophenyl)picolinaMide Methyl Hexafluorobisphenol A Ammonium hexafluorophosphate