2-Acetylthiophene
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2-Acetylthiophene 속성
- 녹는점
- 10-11 °C (lit.)
- 끓는 점
- 214 °C (lit.)
- 밀도
- 1.168 g/mL at 25 °C (lit.)
- 증기압
- 2.7 hPa (50 °C)
- 굴절률
- n
20/D 1.565(lit.)
- 인화점
- 196 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 14g/L
- 물리적 상태
- 액체
- 색상
- 투명한 연한 노란색에서 연한 갈색까지
- 냄새
- 100.00%에서. 유황, 견과류, 헤이즐넛, 호두
- 냄새 유형
- 유황의
- 생물학적 소스
- synthetic
- 수용성
- 물에 불용성.
- 감도
- Light Sensitive
- BRN
- 107910
- 주요 응용
- 향료 및 향
- InChI
- 1S/C6H6OS/c1-5(7)6-3-2-4-8-6/h2-4H,1H3
- InChIKey
- WYJOVVXUZNRJQY-UHFFFAOYSA-N
- SMILES
- CC(=O)c1cccs1
- LogP
- 1.250
- CAS 데이터베이스
- 88-15-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-23/24/25-20/21/22 | ||
| 안전지침서 | 45-38-36/37/39-28-36 | ||
| 유엔번호(UN No.) | UN 2810 6.1/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | OB6300000 | ||
| F 고인화성물질 | 13 | ||
| 자연 발화 온도 | 265 °C DIN 51794 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | TSCA listed | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | II | ||
| HS 번호 | 29349990 | ||
| 스토리지 클래스 | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 2 Oral Acute Tox. 3 Dermal |
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| 독성 | LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg |
2-Acetylthiophene C화학적 특성, 용도, 생산
화학적 성질
clear colorless to slightly yellow liquid용도
2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.화학 반응
Although the condensation product of TeCl4 with 2-acetylthiophene, the bis(2-thiophenoylmethyl)tellurium dichloride has been obtained in poor yields, the reaction product of TeCl4 with 2-acetylpyridine still remains uncharacterized. These observations highlight the substantial role heteroaromatic moiety electronic factors play in the electrophilic reactions of their acetyl derivatives.[1]Safety Profile
Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.Solubility in organics
2-Acetylthiophene is miscible at 25°C with triethylene glycol, methanol, ethanol, n-butanol, diethyl ether, dioxane, cellulose butyl ester, ethyl acetate, acetone, acetonitrile, carbon disulphide, carbon tetrachloride, nitromethane, acetic acid, thiophene, tetranaphthalene, aminobenzene, and benzene . It is immiscible with water, glycerol, ethylene glycol, decahydronaphthalene, cyclohexane, diisobutylene, 1-hexadecene, and n-heptane. When equal volumes are mixed, 2-acetylthiophene is miscible with n-heptane above 60.8°C and with ethylene glycol above 31.1°C.[1] JOHNSON G C. Physical Properties of 2-Acetylthiophene[J]. Journal of the American Chemical Society, 1947, 69 1: 150-152. DOI:10.1021/ja01193a040.
Purification Methods
Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]2-Acetylthiophene 준비 용품 및 원자재
원자재
준비 용품
5-[2-(메틸티오)피리미딘-4-YL]티오펜-2-술포닐염화물
1-(4-브로모-2-티에닐)에탄-1-원
5-THIEN-2-YL-4H-PYRAZOLE-3-카르복실산
에틸5-티엔-2-일-1H-피라졸-3-카르복실레이트
N-(2-티오펜카르보밀)피리디늄브로마이드
3-OXO-3-티오펜-2-YL-프로피온산에틸에스테르
4-Bromo-2-thiophenecarboxylic acid
5-아세틸-2-티오펜카발데하이드
2-Thiopheneacetic acid
2-(2-Bromoacetyl)thiophene
2-Acetyl-5-bromothiophene
2-(2-티에닐)프로피온산
1-[2-히드록시-2(2-티에닐)에틸]피리디늄브로마이드
2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRICACID메틸에스테르
5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
Thiophene-2-acetamide
1,3,5-트리(티오펜-2-일)벤젠
2-Acetyl-4-chlorothiophene
2,5-디히드로티오펜
2-티에닐-2-디메틸아미노에틸케톤HCL
2-Acetylthiophene 공급 업체
글로벌( 733)공급 업체
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| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 |
2354379876@qq.com | China | 244 | 58 |
| Weifang QianJin Fine Chemical Co., Ltd. | 18753684562 |
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| Suzhou Yangen Biotech Co.Ltd | 15051547453 |
sales@yangenbiotech.com | China | 226 | 58 |
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jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 |
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| future industrial shanghai co., ltd | 400-0066400 13621662912 |
sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 |
saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 |
sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 |
Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 |
elainezt@sina.com | China | 1386 | 62 |