살리실 알데히드

살리실 알데히드
살리실 알데히드 구조식 이미지
카스 번호:
90-02-8
한글명:
살리실 알데히드
동의어(한글):
살리실알데히드;살리실알데하이드;O-하이드록시벤즈알데히드;2-하이드록시벤즈알데히드;살리실알;2-포름일
상품명:
Salicylaldehyde
동의어(영문):
2-HYDROXYBENZALDEHYDE;SALICYLIC ALDEHYDE;salicyaldehyde;salicyladehyde;O-HYDROXYBENZALDEHYDE;SALICYLALDEHYD;Benzaldehyde,2-hydroxy-;Benzaldehyde, o-hydroxy-;Salicylaldehyde, 99% 100GR;Salicylal
CBNumber:
CB6127950
분자식:
C7H6O2
포뮬러 무게:
122.12
MOL 파일:
90-02-8.mol
MSDS 파일:
SDS

살리실 알데히드 속성

녹는점
1-2 °C (lit.)
끓는 점
197 °C (lit.)
밀도
1.146 g/mL at 25 °C (lit.)
증기 밀도
4.2 (vs air)
증기압
1 mm Hg ( 33 °C)
굴절률
n20/D 1.573(lit.)
FEMA
3004 | SALICYLALDEHYDE
인화점
170 °F
저장 조건
-20°C
용해도
4.9g/L
물리적 상태
액체
산도 계수 (pKa)
8.37(at 25℃)
색상
맑은 노란색
수소이온지수(pH)
6-8 (H2O, 20℃)Not applicable
냄새
쓴 아몬드
?? ??
약용
수용성
약간 용해됨
감도
Air & Light Sensitive
Merck
14,8326
JECFA Number
897
BRN
471388
Dielectric constant
13.9(20℃)
노출 한도
ACGIH: TWA 5 ppm (Skin)
OSHA: TWA 5 ppm(19 mg/m3)
NIOSH: IDLH 250 ppm; TWA 5 ppm(19 mg/m3); Ceiling 15.6 ppm(60 mg/m3)
안정성
안정적인. 타기 쉬운. 강염기, 강환원제, 강산, 강산화제와 호환되지 않습니다.
InChIKey
SMQUZDBALVYZAC-UHFFFAOYSA-N
LogP
1.66 at 25℃ and pH6.2-6.3
CAS 데이터베이스
90-02-8(CAS DataBase Reference)
NIST
Benzaldehyde, 2-hydroxy-(90-02-8)
EPA
Salicylaldehyde (90-02-8)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,N
위험 카페고리 넘버 21/22-36/38-68-36/37/38-20/21/22-51-36-51/53-22
안전지침서 26-36/37-36/37/39-36-61-64-29/35
유엔번호(UN No.) 3082
WGK 독일 2
RTECS 번호 VN5250000
F 고인화성물질 8-10-23
TSCA Yes
위험 등급 6.1(b)
포장분류 II
HS 번호 29122990
유해 물질 데이터 90-02-8(Hazardous Substances Data)
독성 MLD in rats (mg/kg): 900-1000 s.c. (Binet)
기존화학 물질 KE-20346
그림문자(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P273 환경으로 배출하지 마시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
NFPA 704
2
0 0

살리실 알데히드 C화학적 특성, 용도, 생산

개요

Salicylaldehyde (2-hydroxybenzaldehyde) is an organic compound with the formula C6H4CHO-2-OH. Along with 3-hydroxybenzaldehyde and 4-hydroxybenzaldehyde, it is one of the three isomers of hydroxybenzaldehyde. It is a colorless or pale yellow liquid with a bitter almond odor and a burning taste. It is soluble in alcohol, benzene, and ether, and very slightly soluble in water. Salicylaldehyde is found in shrubs of the genus Spiraea and is usually produced from phenol by the action of chloroform in the presence of an alkali base. It is used in the production of coumarin, saligenin, and salicylaldoxime (an important analytical reagent), and also in analytical chemistry—for example, to detect hydrazine. Besides, salicylaldehyde is a key precursor to various chelating agents and a flavouring ingredient.

화학적 성질

Salicylaldehyde is a colourless to yellow oily liquid with a pungent, irritating, bitter, almond-like odor similar to benzaldehyde, acetophenone and nitrobenzene, but with phenolic notes. It has a nut-like, coumarin flavor at low levels. slightly soluble in water, soluble in ethanol and ether. It turns purple in case of ferric chloride.

출처

Occurs frequently in nature; in the flowers of Spirea ulmaria and other Spireae, in the roots of Crepis foetida L., in the fruits of Pinus avium, in the rind of Rauqolfia caffra, in the leaves of Ceanothus velutinus and in the essential oil of Cinnamomum cassia and of tobacco leaves. Also reported found in grapes, tomato, baked potato, cinnamon bark, cassia leaf, peppermint oil, pennyroyal oil, parmesan cheese, butter, milk powder, roasted chicken, beer, rum, Japanese whiskey, sherry, coffee, tea, soybean, mushroom, buckwheat, Bourbon vanilla, Chinese quince, Muscat grape, vanilla and mastic gum oil.

제조 방법

Salicylaldehyde is synthesized from phenol, chloroform, and alkali according to the Reimer–Tiemman method, which was developed in 1876. starting material for the manufacture of coumarin.

정의

ChEBI: Salicylaldehyde is a hydroxybenzaldehyde carrying a hydroxy substituent at position 2. It has a role as a nematicide and a plant metabolite.

일반 설명

Liquid; colorless or pale yellow; bitter almond odor. Sinks and mixes slowly in water.

반응 프로필

Salicylaldehyde is an aldehyde. Aldehydes are frequently involved in self-condensation or polymerization reactions. These reactions are exothermic; they are often catalyzed by acid. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.

건강위험

Salicylaldehyde is a skin irritant; 500 mg/daycaused moderate irritation to rabbit skin. Itcan have injurious effects on fertility. Studieson rats indicate that subcutaneous administrationof salicylaldehyde in a high doseof >400 mg/kg can produce developmentalabnormalities, fetal death, and postimplantationmortality.
The toxicity of this compound, however,is low. No toxic symptoms were noted.
LD50 value, oral (rats): 520 mg/kg
LD50 value, skin (rats): 600 mg/kg.

화재위험

Combustible. Can react with oxidizing materials.

Purification Methods

It is precipitated as the bisulfite addition compound by pouring the aldehyde slowly and with stirring into a 25% solution of NaHSO3 in 30% EtOH, then standing for 30minutes. The precipitate, after filtering at the pump, and washing with EtOH, is decomposed with aqueous 10% NaHCO3, and the aldehyde is extracted into diethyl ether, dried with Na2SO4 or MgSO4, and distilled, under reduced pressure. Alternatively, salicylaldehyde is precipitated as its Cu complex by adding it to warm, saturated aqueous Cu(OAc)2, shaking and standing in ice. The precipitate is filtered off, washed with EtOH, then Et2O, and decomposed with 10% H2SO4; the aldehyde is extracted into Et2O, dried and vacuum distilled. It was also purified by dry column chromatography on Kieselgel G [Nishiya et al. J Am Chem Soc 108 3880 1986]. The acetyl derivative has m 38-39o (from pet ether or EtOH) and b 142o/18mm, 253o/atm. [Beilstein 8 IV 176.] The oxime, [94-67-7] M 137.1, crystallises CHCl3/pet ether (b 40-60o) with m 57o [Beilstein 8 IV 203.]

폐기물 처리

Salicylaldehyde is burned in a chemicalincinerator equipped with an afterburner andscrubber.

참고 문헌

살리실 알데히드 준비 용품 및 원자재

원자재

준비 용품


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