테르비나핀
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테르비나핀 속성
- 녹는점
- 203-205 °C
- 끓는 점
- 417.9±33.0 °C(Predicted)
- 밀도
- 1.007±0.06 g/cm3(Predicted)
- 증기압
- 0Pa at 25℃
- 저장 조건
- 2-8°C
- 용해도
- 메탄올에 용해됨
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 6.92±0.50(Predicted)
- 색상
- 흰색에서 밝은 노란색
- LogP
- 3.3 at 37℃ and pH7
- CAS 데이터베이스
- 91161-71-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
테르비나핀 C화학적 특성, 용도, 생산
용도
Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies. Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.정의
ChEBI: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the t eatment of skin and nail infections.Indications
Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies.Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.
Antimicrobial activity
Terbinafine is active against a wide range of pathogenic fungi, including dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.), various Candida spp., Aspergillus spp., some dimorphic fungi (Blastomyces dermatitidis, Histoplasma capsulatum and Sporothrix schenckii) and many dematiaceous fungi.원료
Resistance has not been reported.Pharmaceutical Applications
A synthetic allylamine available as the hydrochloride for oral and topical administration.Pharmacokinetics
Oral absorption: 70–80%Cmax 250 mg oral: c. 1 mg/L after 2 h
Plasma half-life: c. 17 h
Volume of distribution: 1000 L
Plasma protein binding: >99%
Blood concentrations increase in proportion to dosage. It is lipophilic and is rapidly and extensively distributed to body tissues. It reaches the stratum corneum by diffusion through the dermis and epidermis, and secretion in sebum. Diffusion from the nail bed is the major factor in its rapid penetration of nails. It is metabolized by the liver and the inactive metabolites are mostly excreted in the urine. The elimination half-life is prolonged in patients with hepatic or renal impairment.
Clinical Use
Terbinafine hydrochloride can be used in Tinea pedis, tinea corporis, tinea cruris, tinea capitis, Onychomycosis caused by dermatophytes.부작용
These include abdominal discomfort, loss of appetite, nausea, diarrhea, headache, impairment of taste, rash and urticaria. Serious skin reactions, including Stevens– Johnson syndrome, and rare hepatotoxic reactions, including jaundice, cholestasis and hepatitis, are occasionally encountered.테르비나핀 준비 용품 및 원자재
원자재
트리뷰틸틴 염화물
아크롤레인
프로파길브로마이드
클로로-2-메틸프로판
1-Methyl-aminomethyl naphthalene
Toluene-3.4-dithiol
에틸브로마이드
3,3-디메틸-1-부틴
부틸리튬
Terbinafine Hydrochloride
탄산나트륨(경회)
N-메틸-1-나프탈렌메틸아민 수화염화물
준비 용품
테르비나핀 공급 업체
글로벌( 323)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 222 | 58 |
Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 |
lijiaqi@aupone.com | China | 43 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 359 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 |
christine@shengqipharm.com | CHINA | 491 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
테르비나핀 관련 검색:
트라이메틸아민(트리메틸아민) 아닐린 디-2-에틸헥실아민 붕산트리메틸 트리메틸아민 하이드로클로라이드 메틸아민 하이드로클로라이드 메틸아민 N-메틸-1-나프탈렌메틸아민 수화염화물 테르비나핀
1-Chloro-6,6-dimethyl-2-heptene-4-yne
Meglumine
Flunixin meglumine
Terbinafine Hydrochloride
cis-Terbinafine Hydrochloride
Methyl-2-naphthaleneMethylaMine Hydrochloride
Terbinafine EP Impurity C
Terbinafine
Dichloropropene