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테르비나핀

테르비나핀
테르비나핀 구조식 이미지
카스 번호:
91161-71-6
한글명:
테르비나핀
동의어(한글):
테르비나핀
상품명:
Terbinafine hydrochloride
동의어(영문):
LAMISIL;sf-86-327;rerbinafine;TERBINAFINE;Terbinafine-d3;(E)-Terbinafine;Terbinafine Impurity 1;Terbinafine(LaMisil, Terbinex);Terbinafine cas 91161-71-6 (whatsapp:+8618830163278);(E)-6,6,N-Trimethyl-N-(1-naphtylmethyl)-2-heptene-4-yne-1-amine
CBNumber:
CB6201128
분자식:
C21H26ClN
포뮬러 무게:
291.44
MOL 파일:
91161-71-6.mol

테르비나핀 속성

CAS 데이터베이스
91161-71-6(CAS DataBase Reference)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36

테르비나핀 C화학적 특성, 용도, 생산

용도

Lamisil (Novartis).

정의

ChEBI: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the t eatment of skin and nail infections.

Antimicrobial activity

Terbinafine is active against a wide range of pathogenic fungi, including dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.), various Candida spp., Aspergillus spp., some dimorphic fungi (Blastomyces dermatitidis, Histoplasma capsulatum and Sporothrix schenckii) and many dematiaceous fungi.

원료

Resistance has not been reported.

Pharmaceutical Applications

A synthetic allylamine available as the hydrochloride for oral and topical administration.

Pharmacokinetics

Oral absorption: 70–80%
Cmax 250 mg oral: c. 1 mg/L after 2 h
Plasma half-life: c. 17 h
Volume of distribution: 1000 L
Plasma protein binding: >99%
Blood concentrations increase in proportion to dosage. It is lipophilic and is rapidly and extensively distributed to body tissues. It reaches the stratum corneum by diffusion through the dermis and epidermis, and secretion in sebum. Diffusion from the nail bed is the major factor in its rapid penetration of nails. It is metabolized by the liver and the inactive metabolites are mostly excreted in the urine. The elimination half-life is prolonged in patients with hepatic or renal impairment.

Clinical Use

Terbinafine hydrochloride can be used in Tinea pedis, tinea corporis, tinea cruris, tinea capitis, Onychomycosis caused by dermatophytes.

부작용

These include abdominal discomfort, loss of appetite, nausea, diarrhea, headache, impairment of taste, rash and urticaria. Serious skin reactions, including Stevens– Johnson syndrome, and rare hepatotoxic reactions, including jaundice, cholestasis and hepatitis, are occasionally encountered.

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