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카올린

카올린
카올린 구조식 이미지
카스 번호:
1332-58-7
한글명:
카올린
동의어(한글):
규산알루미늄;도자기점토;아르길라;알루미늄실리케이트(수화물);중국점토;테라알바;볼루스알바;카올린;흰색교회점토;카오린;할로이사이트;점토
상품명:
KAOLIN
동의어(영문):
Buca;CLAY;SP-33;BOLUS;KAOLIN;Kaowool;Argilla;Catalpo;REDCLAY;Kaoline
CBNumber:
CB6300504
분자식:
H2 Al2 O8 Si2 . H2 O
포뮬러 무게:
258.16
MOL 파일:
1332-58-7.mol

카올린 속성

녹는점
1750 °C
밀도
2,6 g/cm3
굴절률
1.6200
저장 조건
Storage temperature: no restrictions.
용해도
Practically insoluble in diethyl ether, ethanol (95%), water, other organic solvents, cold dilute acids, and solutions of alkali hydroxides.
물리적 상태
Powder
색상
75-96, Hunter Brightness
수소이온지수(pH)
6-7 (50g/l, H2O, 20℃)(slurry)
수용성
insoluble H2O, dilute acids and alkali hydroxides [HAW93]
안정성
Stable. Substances to be avoided include strong oxidizing agents.

안전

안전지침서 22-24/25
WGK 독일 -
RTECS 번호 GF1670500
TSCA Yes
HS 번호 25070090

카올린 C화학적 특성, 용도, 생산

화학적 성질

off-white powder

화학적 성질

Kaolin occurs as a white to grayish-white colored, unctuous powder free from gritty particles. It has a characteristic earthy or claylike taste, and when moistened with water it becomes darker in color and develops a claylike odor.

용도

kaolin (China clay) is a mixture of various aluminum silicates. It is often used in powders and masks given its absorbent, abrasive, bulking, and opacifying properties. This white, soft powder has good coverage and absorption abilities for both water and oil, making it an appropriate absorber of the oil and sweat secreted by the skin. It adheres well to the skin’s surface, yet is easily removed with normal cleansing procedures. Kaolin is considered a non-comedogenic raw material.

용도

Adsorbant.

정의

A mixture of clays, quartz, and feldspar usually containing at least 25% alumina. Ball and china clays are ordinarily used. A slip or slurry is formed with water to form a plastic, moldable mass, which is then glazed and fired to a hard, smooth solid.

생산 방법

Kaolin is a hydrated aluminum silicate obtained by mining naturally occurring mineral deposits. Large deposits are found in Georgia, USA and in Cornwall, England.
Mined kaolin is powdered and freed of coarse, gritty particles either by elutriation or by screening. Impurities such as ferric oxide, calcium carbonate, and magnesium carbonate are removed with an electromagnet and by treatment with hydrochloric acid and/or sulfuric acids.

정의

clay: A fine-grained deposit consistingchiefly of clay minerals. It ischaracteristically plastic and virtuallyimpermeable when wet and crackswhen it dries out. In geology the sizeof the constituent particles is usuallytaken to be less than 1/256 mm. Insoil science clay is regarded as a soilwith particles less than 0.002 mm insize.

Indications

Kaolin is a naturally occurring hydrated aluminum silicate that is prepared for medicinal use as a very finely divided powder. The rationale behind its use in acute nonspecific diarrhea stems from its ability to adsorb some of the bacterial toxins that often cause the condition.

상표명

Vanclay (Vanderbilt);Biskapect;Chloropect;Collodyne;Diaguard forte;Diastat;Donnagel pg liquid;Donnagel-mb;Donnagel-pg;Enterosan;Fissan;Kaodinnon-narcotic;Kaolin w/pectin;Kaomagma with pectin;Kaomycin;Kaoneo;Kaopectate n;Kaoprompt-h;Kao-spen;Kapetolin;Kc;Kln;Medipect;Noventerol;Parepectolin;Pectrolyte;Peterpect;Streptomagma.

World Health Organization (WHO)

Kaolin, a hydrated aluminium silicate, is an absorbent and has been used to treat diarrhoea because of its ability to bind and inactivate bacterial toxins. However, it has been shown to induce only a slight change in stool consistency and there is no evidence that it can reduce the duration or the severity of diarrhoeal disease. It does not reduce fluid and electrolyte losses. It cannot be recommended in the treatment of diarrhoea.

일반 설명

Odorless white to yellowish or grayish powder. Contains mainly the clay mineral KAOLINite (Al2O3 SiO2)2 H2O)2), a hydrous aluminosilicate. KAOLINite has mp 740-1785°C and density: 2.65 g cm-3. KAOLINe is insoluble in water but darkens and develops a earthy odor when wet.

반응 프로필

KAOLIN is stable and chemically unreactive under ordinary conditions.

위험도

Respirable fraction; questionable carcinogen.

Pharmaceutical Applications

Kaolin is a naturally occurring mineral used in oral and topical pharmaceutical formulations.
In oral medicines, kaolin has been used as a diluent in tablet and capsule formulations; it has also been used as a suspending vehicle. In topical preparations, sterilized kaolin has been used in poultices and as a dusting powder. Therapeutically, kaolin has been used in oral antidiarrheal preparations.

공업 용도

The name kaolin comes from the two Chinese words kao-ling, meaning high ridge, and was originally a local term used to describe the region from which the clay was obtained. Kaolin (Al2O32SiO22 H2O) usually contains less than 2% alkalies and smaller quantities of iron, lime, magnesia, and titanium. Because of its purity, kaolin has a high fusion point and is the most refractory of all clays. Lone kaolins are widely used in casting sanitaryware, ceramics, and refractories.
Georgia china clay is one of the most uniform kaolins to be found. Generally speaking, there are two types of Georgia-sourced kaolin, both of which are widely used for casting and other processes. One type imparts unusually high strength and plasticity, and is used for both casting and jiggering where a high degree of workability is required. The other type typically is a fractionated, controlled particle size clay that also behaves well in casting, dries uniformly, and reduces cracking of ware.

부작용

It is almost harmless and is effective in many cases of diarrhea if taken in large enough doses (2–10 g initially, followed by the same amount after every bowel movement). The adsorbents are generally safe, but they may interfere with the absorption of some drugs from the GI tract.

Safety

Kaolin is used in oral and topical pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. Oral doses of about 2–6 g of kaolin every 4 hours have been administered in the treatment of diarrhea.

Veterinary Drugs and Treatments

Although its efficacy is in question, kaolin/pectin is used primarily in veterinary medicine as an oral anti-diarrheal agent. It has also been used as an adsorbent agent following the ingestion of certain toxins. Administration may be difficult due to the large volumes that may be necessary to give orally.

저장

Kaolin is a stable material. Since it is a naturally occurring material, kaolin is commonly contaminated with microorganisms such as Bacillus anthracis, Clostridium tetani, and Clostridium welchii. However, kaolin may be sterilized by heating at a temperature greater than 160°C for not less than 1 hour. When moistened with water, kaolin darkens and becomes plastic.
Kaolin should be stored in a well-closed container in a cool, dry place.

비 호환성

The adsorbent properties of kaolin may influence the absorption of other orally administered drugs. Drugs reportedly affected by kaolin include amoxicillin; ampicillin;cimetidine; digoxin; lincomycin; phenytoin; and tetracycline. Warfarin absorption by rat intestine in vitro was reported not to be affected by kaolin. With clindamycin, the rate (but not the amount) of absorption was affected by kaolin.

Regulatory Status

Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules, powders, syrups, and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK.

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