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4-아미노벤조산

4-아미노벤조산
4-아미노벤조산 구조식 이미지
카스 번호:
150-13-0
한글명:
4-아미노벤조산
동의어(한글):
4-아미노벤조산;P-아미노벤조산;p-아미노벤조산,WET;p-아미노안식향산;파라아미노벤조산;p-아미노벤조산,WET;4-아미노벤조익애씨드;4-아미노벤조익애씨드및아미노기(-NH2)를가진그에스터;파바;트리코크로모겐 인자;파바민;파바시드;파란산;파라미놀;p-카복시아닐린;p-카복시페닐아민;바이타민 BX;바이타민 H;벤조산, 4-아미노-;벤조산, p-아미노-
상품명:
4-Aminobenzoic acid
동의어(영문):
PABA;rvpaba;potaba;Pabacyd;Pabagel;Pabanol;p-amino;Romavit;Actipol;4-Abz-OH
CBNumber:
CB4212038
분자식:
C7H7NO2
포뮬러 무게:
137.14
MOL 파일:
150-13-0.mol

4-아미노벤조산 속성

녹는점
187-189 °C(lit.)
끓는 점
251.96°C (rough estimate)
밀도
1.374 g/mL at 25 °C(lit.)
굴절률
1.5323 (estimate)
인화점
250 °C
저장 조건
2-8°C
용해도
95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow
물리적 상태
Crystalline Powder
산도 계수 (pKa)
2.50, 4.87(at 25℃)
색상
White to light yellow
냄새
Odorless
수소이온지수(pH)
3.5 (5g/l, H2O, 20℃)
pH 범위
3.5
수용성
4.7 g/L (20 ºC)
감도
Air & Light Sensitive
Merck
14,423
BRN
471605
안정성
Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light.
InChIKey
ALYNCZNDIQEVRV-UHFFFAOYSA-N
CAS 데이터베이스
150-13-0(CAS DataBase Reference)
IARC
3 (Vol. 16, Sup 7) 1987
NIST
p-Aminobenzoic acid(150-13-0)
EPA
p-Aminobenzoic acid (150-13-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36/37/38-43
안전지침서 26-36-37/39
WGK 독일 3
RTECS 번호 DG1400000
TSCA Yes
HS 번호 29224995
유해 물질 데이터 150-13-0(Hazardous Substances Data)
독성 LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H413 장기적 영향에 의해 수생생물에 유해의 우려가 있음 수생 환경유해성 물질 - 만성 구분 4
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P272 작업장 밖으로 오염된 의복을 반출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

4-아미노벤조산 MSDS


1-Amino-4-carboxybenzene

4-아미노벤조산 C화학적 특성, 용도, 생산

개요

4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels.

화학적 성질

White to off white crystalline powder

Originator

Pabalate,Robins,US,1949

용도

4-aminobenzoic acid is an aminobenzoic acid isomer that combines with pteridine and glutamic acid to folic acid. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in sunscreens. Also it is used as a component of some medicines e.g analgesic or anesthetic preparations sunscreen agents and bentiromide.

용도

octyl dimethyl PABA (padimate-O; p-aminobenzoic acid) is an FDA-approved sunscreen chemical whose InCI name is now ethylhexyl dimethyl PABA.
gastric acid secretion inhibitor

용도

Widely distributed in nature as a B complex factor. Baker’s yeast contains 5 to 6 ppm, brewer’s yeast from 10 to 100 ppm. Occurs free and in ester form.

용도

PABA is a sunscreen chemical with an approved usage level of 5 to 15 percent. It is found to be irritating to sensitive skin, has the potential to cause sensitization, and is considered too water soluble. once extremely popular, this ingredient has practically disappeared from sunscreen formulations. PABA is a yellowish or colorless acid found in vitamin B complex.

정의

ChEBI: An aminobenzoic acid in which the amino group is para to the carboxy group.

Indications

PABA preparations absorb UVL between 280 and 320 nm. This acid will stain white fabrics, especially cotton. The esters of PABA are slightly less effective and do not stain as much. Cross-sensitization can occur with some sunscreens. In particular, PABA and its derivatives may cross-react with sulfonamides, benzocaine, procaine, paraphenylenediamine, and azo dyes. Padimate-O, the ester form of PABA, is also used for UVB protection.

Manufacturing Process

The following example illustrates in detail the preparation of amino benzoic acids from the hot reaction product obtained by the oxidation of a xylene and containing a mixture of salt, amide salt and diamide of a phthalic acid.
800 cc of hot aqueous oxidation product, obtained from the oxidation of pxylene with ammonium sulfate, hydrogen sulfide and water are boiled and agitated for 4 hours to remove carbon dioxide, hydrogen sulfide and ammonia, sufficient water being added to maintain a constant volume. The mixture is filtered to remove a precipitate containing elemental sulfur. 12 grams of activated charcoal are added to the filtrate and the mixture held at a temperature of 180°F for 20 minutes. Filtration through diatomaceous earth removes color bodies formed during the oxidation process and yields a pale yellow filtrate. The filtrate is acidified with sulfuric acid to a pH of 3 or less to precipitate approximately 49 grams of white solid, comprising a mixture of terephthalic acid and amides of terephthalic acid, which are removed by filtration. This solid is then washed with water at 200°F and redissolved in 200 cc of water containing 28.6 grams of sodium hydroxide.
A mixture of sodium hypochlorite and sodium hydroxide is prepared by adding 27.5 grams of chlorine to a vessel equipped with cooling means and containing a solution of 50 grams of sodium hydroxide in 375 cc of water, thereafter adding sufficient water to produce 500 cc of solution. 190 cc of this cold solution are slowly added to the acid-amide solution previously prepared so as to keep the temperature of the mixture below 55°F. The mixture is stirred for 15 minutes and then heated rapidly to 200°F and maintained at that temperature for one hour. 2 grams of sodium thiosulfate are added to consume excess sodium hypochlorite. The solution is acidified to a pH of 3 or less and filtered hot. The filter cake, comprising about 26.9 grams of terephthalic acid, is then suspended in 300 cc of dilute sulfuric acid of pH about 2, heated to 200°F and filtered hot.
The filtrates are combined, cooled, and extracted with three successive 200 cc portions of ether. The pH of the filtrate is then raised to 3.5 with sodium hydroxide and the filtrate extracted with six successive 200 cc portions of ether to yield the balance of the product. The crude p-aminobenzoic acid product is recovered by evaporation of ether and is suspended in hot benzene, cooled and filtered to remove benzoic and toluic acids together with small amounts of impurities soluble in the filtrate. Recrystallization of the product from 200 cc of water yields 14.5 grams of light tan needles of p-aminobenzoic acid having an acid number of 411 (theoretical value 409).
Aminobenzoic acid can be then purified and decolorized by a process described in US Patent 2,735,865.

상표명

RVPaba Lipstick (ICN).

Therapeutic Function

Sunscreen agent, Antirickettsial

Synthesis Reference(s)

Synthesis, p. 285, 1971
Tetrahedron, 47, p. 8587, 1991 DOI: 10.1016/S0040-4020(01)82402-9

일반 설명

Colorless crystals that discolor on exposure to light and air.

반응 프로필

4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents.

위험도

Questionable carcinogen.

Safety Profile

Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen.

Purification Methods

Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]

4-아미노벤조산 준비 용품 및 원자재

원자재

준비 용품


4-아미노벤조산 공급 업체

글로벌( 600)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Shenyang Simchoice Chemical Co.,Ltd
024-23769576
024-23769576 sales@simchoicechem.com CHINA 62 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3274 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 537 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Hebei Chishuo Biotechnology Co., Ltd.
13292891350 +86 311 66567340
luna@speedgainpharma.com CHINA 1007 58

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