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프로필렌 글리콜

프로필렌 글리콜
프로필렌 글리콜 구조식 이미지
카스 번호:
57-55-6
한글명:
프로필렌 글리콜
동의어(한글):
1,2-디히드록시프로판;(RS)-1,2-프로판디올;1,2-(RS)-프로판디올;1,2-프로판디올;1,2-프로필렌글리콜;2,3-프로판디올;2-히드록시프로판올;DL-1,2-프로판디올;DL-프로필렌글리콜;메틸에틸글리콜;메틸에틸렌글리콜;모노프로필렌글리콜;알파-프로필렌글리콜;이소프로필렌글리콜;프로필렌글리콜;프로필렌글리콜(P.G)-공업용;프로필렌글리콜(P.G)-식첨용;프로필렌글리콜;프로필렌 글리콜;모노프로필렌 글리콜
상품명:
Propylene glycol
동의어(영문):
PG;PGI;gpi;pg12;gpia;PG 12;ZeMea;PG-AAF;PG-ADF;ucar35
CBNumber:
CB8485612
분자식:
C3H8O2
포뮬러 무게:
76.09
MOL 파일:
57-55-6.mol

프로필렌 글리콜 속성

녹는점
-60 °C
끓는 점
187 °C(lit.)
밀도
1.036 g/mL at 25 °C(lit.)
증기 밀도
2.62 (vs air)
증기압
0.08 mm Hg ( 20 °C)
FEMA
2940 | PROPYLENE GLYCOL
굴절률
n20/D 1.432(lit.)
인화점
225 °F
저장 조건
Store at RT.
산도 계수 (pKa)
14.49±0.20(Predicted)
물리적 상태
Viscous Liquid
색상
APHA: ≤10
Specific Gravity
1.038 (20/20℃)1.036~1.040
수소이온지수(pH)
6-8 (100g/l, H2O, 20℃)
폭발한계
2.4-17.4%(V)
수용성
miscible
감도
Hygroscopic
JECFA Number
925
Merck
14,7855
BRN
1340498
InChIKey
DNIAPMSPPWPWGF-UHFFFAOYSA-N
CAS 데이터베이스
57-55-6(CAS DataBase Reference)
NIST
Propylene glycol(57-55-6)
EPA
Propylene glycol (57-55-6)
안전
  • 위험 및 안전 성명
안전지침서 24/25
WGK 독일 1
RTECS 번호 TY2000000
자연 발화 온도 779 °F
TSCA Yes
HS 번호 29053200
유해 물질 데이터 57-55-6(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 19400 - 36000 mg/kg LD50 dermal Rabbit 20800 mg/kg
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
NFPA 704
1
0 0

프로필렌 글리콜 MSDS


Propylene glycol

프로필렌 글리콜 C화학적 특성, 용도, 생산

용도

향료의 주원료로 쓰여 전자담배의 액상에도 들어가고, 식품 첨가물로써도 제한적으로 들어간다. 스프라이트와 조지아가 프로판디올을 함유한 대표적인 식품. 자동차용 부동액에도 들어가는데, 그 특유의 달크름한 향이 바로 이 프로필렌글리콜이다.

용도

색소, 정유, 수지를 녹여 다시 물에 혼합하는 용매로 이용하며, 수용액은 부동액으로 이용된다. 빵의 신전제 및 보습제와 쇼트닝의 신전제로 사용되며, 식품 및 셀로판, 코르크의 유연제로 사용된다. 또한 유화향료의 유화안정제, 방부제, 공기의 살균 등에 쓰이고 바닐라 콩 등의 천연플래버의 추출에도 사용한다.

용도

1) 용제, 부동액, 저온용 윤활유, 살균제(훈증제) 등으로서 이용되며 또 폴리에스테르 수지, 가소제 등의 제조에 이용된다. 2) 의약용으로서는 제2차 세계 대전 중 글리세롤 부족시 그 대용품으로서 등장하였으나, 용해력은 글리세롤보다 우수하고 또 곰팡이의 생장을 방지하며 발효를 받지 않는 점에서도 우수하다는 것이 인정되었다. 수성 교제혹은 물에 잘 녹지 않는 물질의 주사용 용제로서 이용된다.

개요

Propylene glycol is used as antifreeze in breweries and diaries, in the manufacture of resins, as a solvent, and as an emulsifier in food. It was present as an occupational sensitizer in the color-film developer Flexicolor.

화학적 성질

Propylene glycol is a colorless, odorless, syrupy liquid.

화학적 성질

Propylene glycol has a slight, characteristic taste. It is practically odorless. It absorbs moisture when exposed to moist air.

출처

Reported found in several varieties of mushrooms, roasted sesame seed, oat groats, parmesan cheese, cocoa, pecans and truffle.

용도

Used as a solvent.

용도

Next to water, propylene glycol is the most common moisturecarrying vehicle used in cosmetic formulations. It has better skin permeation than glycerin, and it also gives a pleasant feel with less greasiness than glycerin. Propylene glycol is used as a humectant because it absorbs water from the air. It also serves as a solvent for anti-oxidants and preservatives. In addition, it has preservative properties against bacteria and fungi when used in concentrations of 16 percent or higher. There is a concern that propylene glycol is an irritant at high concentrations, though it appears to be quite safe at usage levels under 5 percent.

용도

Propylene Glycol is a humectant and flavor solvent that is a polyhy- dric alcohol (polyol). it is a clear, viscous liquid with complete solu- bility in water at 20°c and good oil solvency. it functions as a humectant, as do glycerol and sorbitol, in maintaining the desired moisture content and texture in foods such as shredded coconut and icings. it functions as a solvent for flavors and colors that are insoluble in water. it is also used in beverages and candy.

생산 방법

Propylene glycol generally is synthesized commercially by starting with propylene, converting to the chlorohydrin, and hydrolyzing to propylene oxide, which is then hydrolyzed to propylene glycol. It can also be prepared by other methods.

Indications

Propylene glycol solution (40% to 60%, v/vCH2CH[OH]CH2OH, propylene glycol) applied to the skin under plastic occlusion hydrates the skin and causes desquamation of scales. Propylene glycol, isotonic in 2% concentration, is a widely used vehicle in dermatologic preparations. Hydroalcoholic gels containing propylene glycol or other substances augment the keratolytic action of salicylic acid. Keralyt gel consists of 6% salicylic acid, 19.4% alcohol, hydroxypropylcellulose, propylene glycol, and water and is an extremely effective keratolytic agent. Overnight occlusion is used nightly until improvement is evident, at which time the frequency of therapy can be decreased to every third night or once weekly. This therapy is well tolerated, is usually nonirritating, and has been most successful in patients with X-linked ichthyosis vulgaris. Burning and stinging may occur when applied to damaged skin. Patients with other abnormalities of keratinization with hyperkeratosis, scaling, and dryness may also benefit.

정의

An alcohol in which the hydroxyl groups are attached to a carbon atom of a branched or straight-chain aliphatic hydrocarbon.

제조 방법

Manufactured by treating propylene with chlorinated water to form the chlorohydrin, which is converted to the glycol by treatment with sodium carbonate solution. It is also prepared by heating glycerol with sodium hydroxide.

상표명

Sentry Propylene Glycol (Union Carbide); Sirlene (Dow Chemical).

Aroma threshold values

Detection: 340 ppm

일반 설명

Thick odorless colorless liquid. Mixes with water.

공기와 물의 반응

Water soluble.

반응 프로필

1,2-Propanediol is hygroscopic. 1,2-Propanediol is sensitive to excessive heat (tends to oxidize at high temperatures). 1,2-Propanediol can react with oxidizing materials. 1,2-Propanediol is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents. 1,2-Propanediol dissolves many essential oils. A mixture of 1,2-Propanediol with hydrofluoric acid and silver nitrate was put in a glass bottle which burst 30 minutes later.

위험도

Toxic.

건강위험

Liquid may irritate eyes.

화재위험

1,2-Propanediol is combustible.

색상 색인 번호

Propylene glycol is used as a solvent, a vehicle for topical medicaments such as corticosteroids or aciclovir, an emulsifier and humectant in food and cosmetics, and as antifreeze in breweries, in the manufactures of resins. It was present as an occupational sensitizer in the color film developer Flexicolor?. Patch tests in aqua are sometimes irritant.

Safety Profile

Slightly toxic by ingestion, skin contact, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, convulsions, changes in surface EEG. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Mutation data reported. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. May react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.

잠재적 노출

Propylene glycol is used as a solvent; emulsifying agent; food and feed additive; flavor, in manu- facture of plastics; as a plasticizer, surface-active agent; antifreeze, solvent, disinfectant, hydroscopic agent; coolant in refrigeration systems; pharmaceutical, brake fluid; and many others.

Carcinogenicity

Dewhurst et al. and Baldwin et al. in studies on the carcinogenicity of other chemicals used propylene glycol as the solvent. As a result they tested propylene glycol alone for carcinogenic activity in rats and mice. Dewhurst et al. used a single injection of 0.2 mL, whereas Baldwin et al. gave rats and mice three to five subcutaneous injections, amount not specified. In neither case were tumors observed during a period of about a year or 2 years .
Wallenious and Lecholm applied propylene glycol to the skin of rats three times a week for 14 months but found no tumor formation. Stenback and Shubik confirmed these findings when they applied propylene glycol at undiluted strength and as a 50 and 10% solution in acetone to the skin of mice during their lifetimes.
No tumors have been reported in the lifetime dietary feeding studies . In fact, Gaunt et al. specifically state that no tumors were found in the rats.

Purification Methods

Dry the diol with Na2SO4, decant and distil it under reduced pressure. [Beilstein 1 IV 2468.]

비 호환성

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong acids (especially nitric acid), strong bases, permanganates, dichromates; may cause a violent reaction.

폐기물 처리

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.All federal, state, and local environmental regulations must be observed.

프로필렌 글리콜 준비 용품 및 원자재

원자재

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