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P-클로로아닐린

P-클로로아닐린 구조식 이미지

카스 번호:: 106-47-8

한글명:: P-클로로아닐린

동의어(한글):: p-클로로아닐린;4-클로로아닐린

상품명:: 4-Chloroaniline

동의어(영문):: P-CHLOROANILINE;PARA CHLORO ANILINE;PARA-CHLORANILINE;4-CHLOROBENZENAMINE;4-Chloranilin;4-CHLORO-PHENYLAMINE;4-Chloroaniline, 98% 5GR;NSC 36941;NCI-C02039;4-Choraniline

CBNumber:: CB8147309

분자식:: C6H6ClN

포뮬러 무게:: 127.57

MOL 파일:: 106-47-8.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 537

P-클로로아닐린 속성

녹는점: 67-70 °C (lit.)

끓는 점: 232 °C (lit.)

밀도: 1,43 g/cm³

증기 밀도: 4.4 (vs air)

증기압: 0.15 mm Hg ( 25 °C)

굴절률: 1.5546

인화점: 120°C

저장 조건: Store below +30°C.

용해도: 2.2g/L

물리적 상태: 결정질 고체

산도 계수 (pKa): 4.15(at 25℃)

색상: 베이지~갈색-보라색

Specific Gravity: 1.2417

냄새: 달콤한

pH 범위: 6.9 at 1.00000 g/l at 20 °C

수소이온지수(pH): 6.9 (1g/l, H2O, 20℃)

수용성: 0.3g/100mL(20℃)

Merck: 14,2118

BRN: 471359

Henry's Law Constant: 1.07 at 25 °C (calculated, Howard, 1989)(x 10^-5 atm?m³/mol)

안정성: 안정적인. 타기 쉬운. 강산화제, 산, 산 염화물, 산 무수물, 클로로포르메이트, 아질산과 호환되지 않습니다. 빛에 민감할 수 있습니다.

LogP: 1.83 at 25℃

CAS 데이터베이스: 106-47-8(CAS DataBase Reference)

IARC: 2B (Vol. 57) 1993

NIST: p-Chloroaniline(106-47-8)

EPA: p-Chloroaniline (106-47-8)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T,N,F
위험 카페고리 넘버	45-23/24/25-43-50/53-52/53-39/23/24/25-11-51/53
안전지침서	53-45-60-61-36/37-16-7
유엔번호(UN No.)	UN 2018 6.1/PG 2
WGK 독일	3
RTECS 번호	BX0700000
F 고인화성물질	8-10-23
자연 발화 온도	685 °C
위험 참고 사항	Toxic/Possible Carcinogen
TSCA	Yes
위험 등급	6.1
포장분류	II
HS 번호	29214210
유해 물질 데이터	106-47-8(Hazardous Substances Data)
독성	LD50 orally in rats: 0.31 g/kg (Smyth)
기존화학 물질	KE-05525

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H350	암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)	발암성 물질	구분 1A, 1B	위험
H410	장기적 영향에 의해 수생생물에 매우 유독함	수생 환경유해성 물질 - 만성	구분 1	경고	P273, P391, P501

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313	노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	1
2		0

P-클로로아닐린 MSDS

4-Chlorobenzenamine

P-클로로아닐린 C화학적 특성, 용도, 생산

화학적 성질

4-Chloroaniline is a colourless to slightly amber-coloured crystalline solid with a mild aromatic odour. It is Soluble in hot water and organic solvents. 4-Chloroaniline has a moderate vapour pressure and n-octanol/ water partition coefficient. It decomposes in the presence of light and air and at elevated temperatures.

물리적 성질

Yellowish-white solid with a mild, sweetish odor. Odor threshold concentration is 287 ppm (quoted, Keith and Walters, 1992).

용도

4-Chloroaniline is an important raw material in production of agricultural chemicals, azo dyes and pigments, cosmetics, and pharmaceutical products. It is used as an intermediate in the manufacture of chromophore AS-LB, as well as in pharmaceutical intermediates such as chlordiazepoxide and phena tincture. It is also an intermediate for the herbicide Anilofos, the insecticide chlorbenzuron and the plant growth regulator Inabenfide.

제조 방법

synthesis of 4-Chloroaniline: p-chloronitrobenzene is used as raw material, Raney nickel is used as catalyst, ethanol is used as solvent, reaction temperature is 50～70°C , hydrogenation pressure is 3.04～3.55MPa, and medium pH=5～6 conditions, carry out Catalytic hydrogenation reaction to obtain 4-Chloroaniline.

주요 응용

4-Chloroaniline is an important building block used in the chemical industry for the production of drugs and dyestuffs. Some benzodiazepine drugs use 4-chloroaniline in their manufacture.

정의

ChEBI: 4-chloroaniline is a chloroaniline in which the chloro atom is para to the aniline amino group. It is a chloroaniline and a member of monochlorobenzenes.

일반 설명

P-chloroaniline appears as a white or pale yellow solid. Melting point 69.5°C.

공기와 물의 반응

Insoluble in cold water. Soluble in hot water [Hawley].

반응 프로필

4-Chloroaniline is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid.

위험도

Toxic by inhalation and ingestion. Possible carcinogen.

건강위험

Inhalation or ingestion causes bluish tint to fingernails, lips, and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.

화재위험

Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires.

Safety Profile

Confirmed carcinogen with experimental neoplastigenic and tumorigenic data. Poison by ingestion, inhalation, sh contact, subcutaneous, and intravenous routes. A skin and severe eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYES

Purification Methods

Crystallise the aniline from MeOH, pet ether (b 30-60o), or 50% aqueous EtOH, then *benzene/pet ether (b 60-70o), and then dry it in a vacuum desiccator. It can be distilled under vacuum (b 75-77o/3mm). It sublimes in a very high vacuum. The acetate crystallises from aqueous MeOH (m 178o, 180o) or EtOH or AcOH (m 173-174o) and has b 331.3o/760mm. [Beilstein 12 III 1325, 12 IV 1116.]

P-클로로아닐린 준비 용품 및 원자재

원자재

P-클로로니트로벤젠 Iron filings Nickel aluMinuM 니켈 철분

준비 용품

imidazol-2-ylamine sulphate cintofen 2-amino-5-chloro-diphenyl methanol 1-CHLORO-4-ISOCYANOBENZENE 2- 아미노 -5- 클로로 벤조 (4-클로로페닐)하이드라진 polyaniline synthesized by means of condensation polymerization 6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 클로헥시딘다이아세테이트 2-Amino-5-chloro-2'-fluorobenzophenone Tenidap 2,6-Dichlorobenzothiazole N-(2-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]ETHYL)-3-METHOXYBENZAMIDE 5-Chloroorthanilic acid Naphthol AS-E 1-(4-Chlorophenyl)piperazine 4-CHLORO-(N-BOC)ANILINE 97 N-(4-chlorophenyl)-2-hydroxy-9H-carbazole-3-carboxamide FLURAZEPAM 아닐로포스 4-클로로페닐 이소시안산 에파비렌즈 M-클로로페놀 4-(4-(Chlorophenyl)imino)-1-isopropyl piperidine 디플루벤주론 Nitrazepam Chlorhexidine diacetate Lorcainide chlorbenzuron 6-CHLORO-2-METHYLQUINOLINE 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE 클로플루카반 N-(4-chlorophenyl)-1-isopropylpiperidin-4-amine

P-클로로아닐린 공급 업체

글로벌( 537)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Dalian Richfortune Chemicals Co., Ltd	0411-84820922 8613904096939	sales@richfortunechem.com	China	303	57
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58