NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
정의
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.
일반 설명
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
생물학적 활성
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ .