빈크리스틴 황산염
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빈크리스틴 황산염 속성
- 녹는점
- 300 °C
- 끓는 점
- 273-281 °C
- 알파
- D26 +8.5° (c = 0.8)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- 메탄올: 용해성20mg/mL
- 물리적 상태
- 동결건조된 분말
- 색상
- 흰색에서 황백색까지
- 수용성
- 24 ºC에서 >=1g/100mL
- BRN
- 3924631
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. 증류수 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- 주요 응용
- pharmaceutical (small molecule)
- InChIKey
- AQTQHPDCURKLKT-HSMPTBRCNA-N
- SMILES
- OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
- IARC
- 3 (Vol. 26, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 61-36/37/38-63-23/24/25-68-62-25 | ||
| 안전지침서 | 22-24/25-53-45-37/39-26-36/37/39-36/37 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | OH6340000 | ||
| F 고인화성물질 | 8-10 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II | ||
| HS 번호 | 29399990 | ||
| 스토리지 클래스 | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Oral Muta. 2 Repr. 2 |
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| 독성 | LD50 intraperitoneal in mouse: 3mg/kg |
빈크리스틴 황산염 C화학적 특성, 용도, 생산
화학적 성질
Crystalline Solid용도
Vincristine sulfate, is used as an anticancer agent, microtubule disrupter, Induces apoptosis in human lymphoma cells. Other applications include as a cell cycle arresting, apoptotic inducing alkaloid.일반 설명
Vincristine sulfate appears as an anticancer drug. White to slightly yellow, amorphous or crystalline powder. Sensitive to light. Odorless. pH (0.1% solution) 3.5 - 4.5. (NTP, 1992)공기와 물의 반응
Very hygroscopic. Water soluble.반응 프로필
Sensitive to hydrolysis, oxidation and heat. Incompatible with strong oxidizing agents. .화재위험
Flash point data for Vincristine sulfate are not available; however, Vincristine sulfate is probably combustible.생물학적 활성
Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.Clinical Use
Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.신진 대사
Vincristine is metabolised in the liver by the cytochrome P450 isoenzymes CYP3A4 and CYP3A5 and excreted mainly in the bile; about 70-80 % of a dose is found in faeces, as unchanged drug and metabolites (40-50 %), while 10-20 % appears in the urine.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours.
Purification Methods
The salt is recrystallised from MeOH. It has UV max at 220, 255 and 296nm (log 4.65, 4.21 and 4.18). It is a monoamine oxidase inhibitor and is used in cancer research [Son et al. J Med Chem 33 1845 1990, Horio et al. Proc Natl Acad Sci USA 85 3580 1988].Mode of action
Vincristine Sulfate is the sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.Toxicity evaluation
The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.빈크리스틴 황산염 준비 용품 및 원자재
원자재
준비 용품
빈크리스틴 황산염 공급 업체
글로벌( 577)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| S&Y Biochem Co.,Ltd | +86-17774091612; +8617774091612 |
marketing@sybiochem.com | China | 281 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 973 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +86-15271838296; +8615271838296 |
kyra@quanjinci.com | China | 1512 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 |
sales@sjar-tech.com | China | 504 | 58 |
| Shandong Xuhuang New material CoLTD | +86-15095020839 +86-17660422208 |
China | 726 | 58 | |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 |
Amyjiyunzen@yeah.net | China | 672 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 |
sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21599 | 55 |