Tizanidine
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Tizanidine 속성
- 녹는점
- 221-223°
- 끓는 점
- 391.2±52.0 °C(Predicted)
- 밀도
- 1.82±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- H2O: ~29 mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 7.48±0.10(Predicted)
- 색상
- 하얀색
- CAS 데이터베이스
- 51322-75-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 22-36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | DK9910000 | ||
독성 | LD50 orally in mice: 235 mg/kg (Sayers) |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Tizanidine C화학적 특성, 용도, 생산
개요
Tizanidine is a centrally-acting muscle relaxant useful in the treatment of muscle spasms and a variety of spastic conditions.용도
Labeled Tizanidine, intended for use as an internal standard for the quantification of Tizanidine by GC- or LC-mass spectrometry.정의
ChEBI: 2,1,3-Benzothiadiazole substituted at C-4 by a Delta1-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.Mechanism of action
Tizanidine is a centrally active muscle relaxant analogue of clonidine that is approved for use in reducing spasticity associated with cerebral or spinal cord injury. Its mechanism of action for reducing spasticity suggests presynaptic inhibition of motor neurons at the α2-adrenergic receptor sites, reducing the release of excitatory amino acids and inhibiting facilitatory ceruleospinal pathways, thus resulting in a reduction in spasticity. Tizanidine only has a small fraction of the antihypertensive action of clonidine, presumably because of action at a selective subgroup of α2C-adrenoceptors, which appear to be responsible for the analgesic and antispasmodic activity of imidazoline α2-agonists(20).Clinical Use
Tizanidine is a centrally acting adrenergic α2 receptor agonist used to treat chronic muscle spasticity conditions, such as multiple sclerosis.부작용
Postulated mechanisms include α2 receptor-mediated decreased release of norepinephrine and serotonin from spinal interneurons. Tizanidine is structurally related to the α2 agonist clonidine that is used to treat hypertension; however, the blood pressure–lowering potency of tizanidine is approximately 10 to 20% that of clonidine. Nevertheless, patients may experience hypotension with tizanidine, together with muscle weakness, that may result in dizziness and falls in mobile patients. Tizanidine is rapidly and almost completely absorbed from the gastrointestinal tract; however, the estimated bioavailability is only 10 to 15% because of extensive first-pass metabolism, mainly by CYP1A2, which results in oxidative degradation of the imidazoline ring and hydroxylation of the aromatic system. Elevated liver enzyme values are not frequent with tizanidine use. Hepatic injury and death because of liver failure have been reported, however, and this complication should be considered in view of its marginal antispasmodic efficacy. Other frequently reported side effects of tizanidine are drowsiness and dry mouth. Clonidine also has been used to treat spasticity; however, even less high-quality clinical study data are available for this agent.Tizanidine 준비 용품 및 원자재
원자재
염산
에틸렌디아민
수산화나트륨
2,1,3-Benzothiadiazole
요오드 메탄
싸이오사이안산암모늄(로단암몬)
염화벤조일
1H-Imidazole, 2-chloro-4,5-dihydro-, hydrochloride (1:1)
4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID
1-Acetyl-2-imidazolidinone
4-Amino-5-chloro-2,1,3-benzothiadiazole
준비 용품
Tizanidine 공급 업체
글로벌( 132)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3581 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9271 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29067 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +8617731987558 |
xingjiu@xingjiubiotech.com | China | 990 | 58 |
sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12382 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 |
cbc@coresyn.com | China | 9991 | 58 |
Tizanidine 관련 검색:
5-메틸-1,3,4-티아디아졸-2-티올 트리알릴아민 이미다졸 디-2-에틸헥실아민 메토클로프라미드 디하이드로미르세놀 클로로디플루오르메탄
Niclosamide
2,1,3-Benzothiadiazole
Moclobemide
Metoclopramide hydrochloride
Tizanidine Related Compound B
Cinchonidine
2,1,3-BENZOXADIAZOL-4-AMINE
Tizanidine Related Compound A
TIZANIDINE HCL,TIZANIDINE HYDROCHLORIDE,TIZANIDINE HYDROCHLORIDE
Tizanidine Related Compound C
TIZANIDINE-D4