염화벤조일

염화벤조일 속성

염화벤조일 MSDS

Benzoyl chloride

염화벤조일 C화학적 특성, 용도, 생산

개요

벤조산의 산염화물. 자극적인 냄새가 나는 무색 액체로, 에테르에 녹고 물에서 분해된다.

용도

벤조일화제(benzoyl化劑)로 널리 쓴다.

화학적 성질

Benzoyl chloride is a colorless to slight brown liquid with a strong, penetrating odor; vapor causes tears. Soluble in ether and carbon disulfide; decomposes in water. Combustible. It is a liquid acyl chloride used as a benzoylating agent.

생산 방법

Benzoyl chloride can be prepared from benzoic acid by reaction with PCl5 or SOCl2, from benzaldehyde by treatment with POCl3 or SO2 Cl2, from benzotrichloride by partial hydrolysis in the presence of H2SO4 or FeCl3, from benzal chloride by treatment with oxygen in a radical source, and from several other miscellaneous reactions. Benzoyl chloride can be reduced to benzaldehyde, oxidized to benzoyl peroxide, chlorinated to chlorobenzoyl chloride and sulfonated to m-sulfobenzoic acid. It will undergo various reactions with organic reagents. For example, it will add across an unsaturated (alkene or alkyne) bond in the presence of a catalyst to give the phenylchloroketone:

정의

ChEBI: Benzoyl chloride is an acyl chloride consisting of benzene in which a hydrogen is replaced by an acyl chloride group. It is an important chemical intermediate for the manufacture of other chemicals, dyes, perfumes, herbicides and pharmaceuticals. It has a role as a carcinogenic agent. It is an acyl chloride and a member of benzenes. It is functionally related to a benzoic acid.?

일반 설명

Benzoyl chloride appears as a colorless fuming liquid with a pungent odor. Flash point 162 °F. Lachrymator, irritating to skin and eyes. Corrosive to metals and tissue. Density 10.2 lb / gal. Used in medicine and in the manufacture of other chemicals.

반응 프로필

Benzoyl chloride reacts violently with protic solvents such as alcohols, with amines and amides (for example dimethylformamide [Bretherick 1979 p. 6] ) and with inorganic bases. Causes the violent decomposition of dimethyl sulfoxide [Chem. Eng. News 35(9): 87 1957]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Friedel-Crafts acylation of naphthalene using Benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent [Clar, E. et al., Tetrahedron, 1974, 30, 3296].

위험도

Highly toxic. Strong irritant to skin, eyes, and mucous membranes, and via ingestion, inhala- tion. Upper respiratory tract irritant. Probable car- cinogen.

건강위험

INHALATION: may irritate eyes, nose and throat. INGESTION: causes acute discomfort. SKIN: causes irritation and burning.

화학 반응

Reactivity with Water Slow reaction with water to produce hydrochloric acid fumes. The reaction is more rapid with steam; Reactivity with Common Materials: Slow corrosion of metals but no immediate danger; Stability During Transport: Not pertinent; Neutralizing Agents for Acids and Caustics: Soda ash and water, lime; Polymerization: Does not occur; Inhibitor of Polymerization: Not pertinent.

Mechanism of action

Indicative of its high reactivity (relative to alkyl chlorides), benzyl chloride reacts with water in a hydrolysis reaction to form benzyl alcohol and hydrochloric acid. In contact with mucous membranes, hydrolysis produces hydrochloric acid. Thus, benzyl chloride is a lachrymator and has been used in chemical warfare. Theoretically, for every mole of benzyl chloride reacted, one mole of hydrochloric acid is released[1].

Toxicology

Benzoyl chloride is of low acute oral toxicity in rats (LD₅₀ 2529 mg/kg). It is more toxic by inhalation (LC₅₀ 230 ppm, 4 h in male rats and 314 ppm, 4 h in female rats). The compound is irritating to skin, mucous membranes, eyes, and the respiratory tract.
When benzoyl chloride or solutions of benzoyl chloride in benzene were applied to the skin of mice for up to 10 months irritation and keratinization resulted, and to some extent, ulceration and necrosis of the skin occurred. A few tumors (skin, lung) were observed in those mice. There is no clear evidence that benzoyl chloride is mutagenic.
For humans, benzoyl chloride is classified as a lachrymator. It is irritating to the skin, eyes, and mucous membranes. The available data are inadequate to evaluate the carcinogenic potential of benzoyl chloride to humans.

잠재적 노출

Benzoyl chloride is used as a chemical intermediate; in organic synthesis; to produce other chemicals, dyes, perfumes, herbicides, and medicines.

운송 방법

UN 1736 Benzoylchloride, Hazard class: 8; Labels: 8—Corrosive material.

Purification Methods

A solution of benzoyl chloride (300mL) in *C6H6 (200mL) is washed with two 100mL portions of cold 5% NaHCO3 solution, separated, dried with CaCl2 and distilled [Oakwood & Weisgerber Org Synth III 113 1955]. Repeated fractional distillation at 4mm Hg through a glass helices-packed column (avoiding porous porcelain or silicon-carbide boiling chips, and hydrocarbon or silicon greases on the ground joints) gave benzoyl chloride that did not darken on addition of AlCl3. Further purification is achieved by adding 3 mole% each of AlCl3 and toluene, standing overnight, and distilling off the benzoyl chloride at 1-2mm [Brown & Jenzen J Am Chem Soc 80 2291 1958]. Refluxing for 2hours with an equal weight of thionyl chloride before distillation has also been used. [Beilstein 9 IV 721.] Strong IRRITANT. Use in a fume cupboard.

비 호환성

May form explosive mixture with air. Contact with heat, hot surfaces, and flames causes decomposition, forming phosgene and hydrogen chloride. Water contact may be violent; forms hydrochloric acid. Reactions with amines, alcohols, alkali metals, dimethyl sulfoxide, strong oxidizers, and metal salts may be violent, causing fire and explosions. Attacks metals in the presence of moisture, forming explosive hydrogen gas. Attacks some plastics, rubber or coatings.

폐기물 처리

Pour into sodium bicarbonate solution and flush to sewer.

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공급자	전화	이메일	국가	제품 수	이점
Wuhan Biet Co., Ltd.	+8617320528784	min@biet.com.cn	China	41	58
Ningxia Jinhua Chemical Co.,Ltd	025-52279164	info@nxjhchem.com	China	79	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Taizhou Suze Chemical Materials Co.,Ltd.	+86-0523-86392777 +86-19825580222	nick.miao@suzechem.com	China	23	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Anhui Royal Chemical Co., Ltd.	+86-25-86655873 +8613962173137	marketing@royal-chem.com	China	142	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1011	58

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