5-Nitroindazole inhibits citrulline formation by Ca2+-calmodulin (CaM)-dependent nitric oxide synthase from bovine brain. Nitration of 5-nitroindazole with nitric acid and acetic anhydride yields 3,5-dintroindazole and 2,5-dinitroindazole.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 21, p. 1063, 1984 DOI:10.1002/jhet.5570210428 Organic Syntheses, Coll. Vol. 3, p. 660, 1955